The Nathan Shock Centers

Austad, Steven N.; Willik, Odette van der; Lederman, Stephanie; Kerr, Candace L.

doi:10.1007/s11357-021-00425-y

Cited by 2 publications

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“…Such initiatives play a crucial role in fostering the incorporation of geroscience concepts into pathological research. By providing access to advanced technologies and expertise, these centers enable researchers to delve deeper into the complexities of aging at a molecular and cellular level [282][283][284][285][286][287][288][289][290]. This approach not only enhances our understanding of the aging process but also accelerates the development of targeted interventions for age-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Geroscience and pathology: a new frontier in understanding age-related diseases

Fekete,

Major,

Feher

et al. 2024

Pathol. Oncol. Res.

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Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel the intricate relationship between the aging process and pathogenesis of age-related diseases. This paper explores the pivotal role played by geroscience in reshaping our understanding of pathology, with a particular focus on age-related diseases. These diseases, spanning cardiovascular and cerebrovascular disorders, malignancies, and neurodegenerative conditions, significantly contribute to the morbidity and mortality of older individuals. We delve into the fundamental cellular and molecular mechanisms underpinning aging, including mitochondrial dysfunction and cellular senescence, and elucidate their profound implications for the pathogenesis of various age-related diseases. Emphasis is placed on the importance of assessing key biomarkers of aging and biological age within the realm of pathology. We also scrutinize the interplay between cellular senescence and cancer biology as a central area of focus, underscoring its paramount significance in contemporary pathological research. Moreover, we shed light on the integration of anti-aging interventions that target fundamental aging processes, such as senolytics, mitochondria-targeted treatments, and interventions that influence epigenetic regulation within the domain of pathology research. In conclusion, the integration of geroscience concepts into pathological research heralds a transformative paradigm shift in our understanding of disease pathogenesis and promises breakthroughs in disease prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Geroscience and pathology: a new frontier in understanding age-related diseases

Fekete,

Major,

Feher

et al. 2024

Pathol. Oncol. Res.

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“…As its name implies, the NSC3 is charged with enhancing communication and collaboration among the centers, also enhancing their visibility to the general public as leaders in the research community. 3 The NSC3 also serves as a forum of scientific exchange among NSC investigators and to the rest of the research community. It works with the NSC directors to develop, distribute, and implement a shared state-of-the art approach and commitment to the renewed NIH emphasis on rigor, reproducibility, and transparency in preclinical research.…”

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confidence: 99%

Happy 50th to the National Institute on Aging and happy 30th to the Nathan Shock Centers

Austad,

Richardson,

van der Willik

et al. 2024

J American Geriatrics Society

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As we celebrate the 50th anniversary of the founding of the National Institute on Aging (NIA) in 2024, it might also be appropriate to remind ourselves that it is also the 30th anniversary of the initial Request for Applications for the Nathan Shock Centers of Excellence in the Basic Biology of Aging, now in their 29th year of existence.These centers were named for Nathan Shock, who served for 35 years as head of the Gerontology Research Center Branch of the National Institute on Aging and helped put the study of human aging on a firm scientific foundation. In his research, Dr. Shock stressed the importance of longitudinal studies, and to that end co-founded in 1958 the Baltimore Longitudinal Study of Aging, 1 still the most comprehensive, continuous longitudinal study of human aging, now going strong in its 66th year. The Nathan Shock Centers were the brain child of Richard A. Sprott, Director of what is now the Division of Aging Biology of the NIA. He felt that basic, mechanistic aging research needed the same sort of centers of

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The Nathan Shock Centers

Cited by 2 publications

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Geroscience and pathology: a new frontier in understanding age-related diseases

Geroscience and pathology: a new frontier in understanding age-related diseases

Happy 50th to the National Institute on Aging and happy 30th to the Nathan Shock Centers

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