2016
DOI: 10.1038/npp.2016.117
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The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory

Abstract: Sustained abstinence from cocaine use is frequently compromised by exposure to environmental stimuli that have previously been strongly associated with drug taking. Such cues trigger memories of the effects of the drug, leading to craving and potential relapse. Our work has demonstrated that manipulating cocaine-cue memories by destabilizing them through interfering with the reconsolidation process is one potential therapeutic tool by which to prolong abstinence. Here, we examine the use of the naturally occur… Show more

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Cited by 22 publications
(42 citation statements)
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“…Suppression of BDNF and TrkB by garcinol as well as garcinol‐induced upregulation of GABA A and GAD65 were identified as anti‐epileptic modes of action of garcinol . Garcinol (10 mg/kg, i. p.) also showed beneficial effects in rats exposed to cocaine and it inhibited reinstatement by reconsolidation‐based modes following cocaine reactivation . Reactivated memories were affected by garcinol which displayed long‐lasting effects and, thus, garcinol can support drug abstinence and be a suitable therapy for psychopathologies such as drug addiction.…”
Section: New Effects On Inflammation Processes and Neurodegenerative mentioning
confidence: 99%
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“…Suppression of BDNF and TrkB by garcinol as well as garcinol‐induced upregulation of GABA A and GAD65 were identified as anti‐epileptic modes of action of garcinol . Garcinol (10 mg/kg, i. p.) also showed beneficial effects in rats exposed to cocaine and it inhibited reinstatement by reconsolidation‐based modes following cocaine reactivation . Reactivated memories were affected by garcinol which displayed long‐lasting effects and, thus, garcinol can support drug abstinence and be a suitable therapy for psychopathologies such as drug addiction.…”
Section: New Effects On Inflammation Processes and Neurodegenerative mentioning
confidence: 99%
“…Decrease of mortality and of seizure scores in vivo [86] Suppression of BDNF and TrkB and upregulation of GABA A and GAD65 [86] Cocaine abuse Support of drug abstinence [87,88] Inhibition of reinstatement by reconsolidationbased modes [85,88] reduced arterial adherence and infiltration by leukocytes and macrophages in vivo when administered in a Pluronic gel enabling a slow garcinol drug release. [66] In contrast to these and other previous findings about the considerable anti-inflammatory activities of garcinol, a newer study described the enhancement of lipopolysaccharide(LPS)-induced inflammation by intraperitoneally administered garcinol (injection of 10 mg/kg in DMSO) both in vitro and in vivo.…”
Section: Epilepsymentioning
confidence: 99%
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“…For example, a single US-reactivation session followed by pharmacological treatment in a rodent model of cocaine self-administration blocks cue-induced reinstatement to multiple CSs paired with the drug (Dunbar and Taylor Under Review). The pharmacological agent used was garcinol, a naturally-occurring histone acetyltransferase inhibitor that can safely be given to humans and also blocks reconsolidation after CS reactivation (Monsey et al 2016; Maddox et al 2013). Importantly, US-reactivation destabilized the memory whether or not it was administered through the same route as during self-administration training, showing high translational potential for the development of clinical reconsolidation-based treatments for drug addiction, which is associated with several routes of drug administration.…”
Section: Limitations Of the Clinical Application Of Reconsolidationmentioning
confidence: 99%
“…Developing an effective clinical treatment that requires fewer sessions and less time will increase patient retention, decrease costs, and improve treatment outcomes. An exciting candidate to examine for the pharmacological approach is garcinol, which can be given safely to humans and which blocks reconsolidation in rodents (Dunbar and Taylor Under Review; Maddox et al 2013; Monsey et al 2016). …”
Section: Recommendationsmentioning
confidence: 99%