“…In fact, research studies addressing setting-relevant questions need to be performed also in low-income and middle-income countries. 5 Understandably, there is urgency for identifying alternatives to sargramostim for clinical use outside of North America, but we urge caution in using G-CSF as an alternative without further study, as these agents are not interchangeable. Healthcare providers need to continue to advocate for our patients and focus on the goal of providing affordable access to the most effective therapies for all patients with high-risk neuroblastoma.…”