The negative prognostic value of TRAIL overexpression in oral squamous cell carcinomas does not preclude the potential therapeutic use of recombinant TRAIL

Monasta, Lorenzo; Rubini, Corrado; Stramazzotti, Daniela; Palmieri, Annalisa; Melloni, Elisabetta; Knowles, Alessandra; Ronfani, Luca; Zauli, Giorgio; Secchiero, Paola

doi:10.1007/s10637-010-9586-0

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…TRAIL-R expression in the tumor correlated to worse prognosis, this might be explained by the use of decoy receptors to evade apoptosis induction. 69 FAP-1 is a regulating molecule blocking Fas-mediated apoptosis, thus explaining the result that low FAP 1 correlated to a better prognosis. 90 For some markers/ligands (GrB, NKp46, RCAS1, FAP1) the findings confirm the proposed pathophysiological mechanism as described in the literature.…”

Section: Discussionmentioning

confidence: 96%

“…However, they investigated TRAIL-R and found that TRAIL-R DR5 positively correlated with tumor size. 69 One study investigated the prognostic role of Granzyme B (GrB) and found that there was a higher peritumoral density of Granzyme B in the non-metastatic study group in comparison with the metastatic study group. High peritumoral GrB correlated with better survival.…”

Section: Death Receptors As Predictors For Survival and Clinicopatholmentioning

confidence: 99%

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The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

et al. 2020

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Background: Despite the improvement in therapeutic interventions, 5-year survival rates in Head and Neck Squamous Cell Carcinoma (HNSCC) are limited. HNSCC is an immunogenic cancer type for which molecular stratification markers are lacking. Tumor-infiltrating lymphocytes (TILs) have shown a favorable prognostic role in different cancer types. This study focused on the prognostic role of NK cells in HNSCC. Methods: A systematic search was conducted in Pubmed/Medline and Embase. Articles that correlated the presence of intratumoral NK cells, activating/inhibiting receptors, death receptors, or their ligands with clinicopathologic characteristics or survival were included. A meta-analysis was performed that assessed the association between CD56+ and CD57+ and overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Results: A pooled analysis indicated a favorable prognostic role of CD56+ and CD57+ NK cells for OS (HR 0.19 CI 0.11-0.35). NK cell markers NKp46 and Granzyme B (GrB) also have a favorable prognostic role. NK cell ligand Fas correlated with better survival and better characteristics. NK cell marker Fas-L, NK cell ligands CEACAM1, RCAS1, CD70 and TRAIL-R, and effector molecules of these ligands, FADD and FAP1, correlated to features of worse prognosis. Conclusion: A favorable prognostic role of NK cells in HNSCC was found in this review. Some studies implied the opposite, indicating the fine balance between pro-and anti-tumor functions of NK cells. Future studies using homogeneous patient cohorts regarding tumor subsite and treatment modality, are necessary to further provide insight into the prognostic role of NK cells.

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Section: Discussionmentioning

confidence: 96%

Section: Death Receptors As Predictors For Survival and Clinicopatholmentioning

confidence: 99%

The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

The negative prognostic value of TRAIL overexpression in oral squamous cell carcinomas does not preclude the potential therapeutic use of recombinant TRAIL

Cited by 1 publication

References 26 publications

The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

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