The Neonate

Atherton, D. J.; and, A. R. Gennery; Cant, A. J.

doi:10.1002/9780470750520.ch14

Cited by 28 publications

(53 citation statements)

References 789 publications

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“…It is assumed that this sebaceous gland activity reflects the stimulation by placentally transferred maternal androgen, particularly by dehydroepiandrosterone. 16 We also observed that 128 neonates (29.77%) had Milia which is comparable to another Indian study that showed a similar finding of 27%. 1 Sachdeva et al have mentioned that in their study a higher incidence of milia in term babies and those babies weighing more than 2500 gm which is similar to our finding too, however, statistical significance was not established.…”

Section: Discussionsupporting

confidence: 89%

Clinical study of neonatal skin lesions

Patel

Shetty

et al. 2017

Int J Res Dermatol

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<div class="WordSection1">Background: A thorough knowledge of the skin changes, physiological as well as acquired, in neonates is of prime importance for the dermatologist as well as paediatrician.Methods: A total of 430 randomly selected live-born neonates delivered and admitted to the postpartum ward or to the Neonatal Intensive Care Unit and neonates attending the Dermatology Outpatient Department of a tertiary care institute were included in this study after taking written informed consent. A detailed assessment of history was performed and a detailed dermatological examination of each neonate was carried out. Laboratory procedures were performed to confirm diagnosis if required. Data was analyzed using SPSS ver. 20.Results: Most common physiological skin change observed was Mongolian spot (65.35%) followed by Erythema Toxicum Neonatorum (51.63%), Epstein’s pearls (46.97%) and Sebaceous gland hyperplasia (45.81%). Lanugo hair was seen in 16.74% neonates. Among congenital skin lesions, Salmon patch was seen in 15.58% of the neonates whereas congenital melanocytic nevi are seen in 4.19% of the neonates. Diaper dermatitis was the most common acquired skin manifestation seen in 5.81% of cases. Conclusions: Neonates are prone to suffer from a wide range of dermatological problems, physiological as well as pathological. These manifestations are unique to the neonates. A detailed history and awareness of the clinical presentation facilitates the confirmation of the diagnosis.</div>

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Section: Discussionsupporting

confidence: 89%

Clinical study of neonatal skin lesions

Patel

Shetty

et al. 2017

Int J Res Dermatol

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“…This is in agreement with study by Cooke. 24 We observed it to be 10 times more frequent in preterm babies than full term babies as has been noted by Saraeli et al and Dash et al confirming the view that preterm new born show definite evidence of barrier immaturity. Present study noted a much less frequency and this may be attributed to the breast-feeding practice in this part of country.…”

Section: Eczematoussupporting

confidence: 88%

A clinical study of neonatal dermatosis

Shah

Yaseen

Gupta³

2017

Int J Contemp Pediatr

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INTRODUCTIONThe neonatal period is defined as first four weeks of extra uterine life. The skin of the newborn serves a pivotal role in transition from aqueous intra uterine environment to extra uterine terrestrial life. Neonatal skin differs in structure and function from that of adults and hence the dermatoses seen during this period differ in their clinical presentation and therapeutic requirements. The skin of neonate is thinner less hairy has, weaker inter cellular attachments, increased susceptibility to external irritants, microbial infections and decreased contact allergen reactivity.1 The appreciation of normal physiological phenomena and their differentiation from more significant cutaneous disorders of new born is critical for dermatologist in order to modify the approach for caring of new born skin during this period. Most of the studies.2-4 regarding neonatal dermatoses have focused on the first few hours or days after birth but literature regarding full neonatal period is meagre and no such study is available from this part of the country and hence this study is an attempt to provide the frame work for an effective ABSTRACT Background: The neonatal period is the first 4 weeks of extra-uterine life. Neonatal dermatology encompasses a spectrum of cutaneous disorders from benign to life threatening. The present study was undertaken to evaluate the various dermatoses and hence assess the spectrum of dermatological conditions during the neonatal period and to study the relationship of neonatal dermatoses with maturity and birth weight of the neonates. Methods: Three hundred neonates with cutaneous manifestations, attending the OPD of dermatology and Paediatrics during one year period, were studied. Neonates receiving phototherapy and those with lesions secondary to trauma were excluded. Clinical history coupled with complete general physical, systemic and dermatological examination. Results: Three hundred cases of neonatal dermatoses were included in study. Out of 300 cases, 179 (59.7%) were male babies and 121 (140.3%) were female (sex ratio 1:5), 271 (70.3%) were term babies, 27 (9%) were preterm and 2 (0.7%) were post term. Transient/non-infective cutaneous lesions were the commonest 144 (48%) followed by Infectious 68 (22.67%), eczematous disorder 33 (11%) and pigmentary dermatoses 25 (8.33). Vascular lesions and hematomas accounted for 18 (6%) while genodermatoses were seen 7 (2.33%). 5 cases of subcutaneous fat disorders were observed. Conclusions: As the spectrum of neonatal dermatology is vast, its knowledge to dermatologist is very important so as to differentiate the more common benign disorders from less frequent life-threatening dermatoses, so that timely intervention could facilitate a better therapeutic outcome.

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“…The prevalence of seborrheic dermatitis peaks when sebaceous gland activity is high (15), during the first 3 months of life (infantile seborrheic dermatitis) and during puberty, but also when sebum excretion is reduced after the age of 50 years (61). Seborrheic dermatitis flares are also observed in the fall, when the level of sebum production is decreased compared to that in summer (345).…”

Section: Seborrheic Dermatitismentioning

confidence: 99%

“…Infantile seborrheic dermatitis describes a characteristic, usually nonpruritic, eczematous or psoriasiform eruption that usually appears between the second week and the sixth month of life and can involve the face, scalp, trunk, and sternum area, individually or in any combination (15,343). The lesions might coalesce, especially on the face and flexures, but when on the trunk, they are more distinct.…”

Section: Seborrheic Dermatitismentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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The Neonate

Cited by 28 publications

References 789 publications

Clinical study of neonatal skin lesions

Clinical study of neonatal skin lesions

A clinical study of neonatal dermatosis

The Malassezia Genus in Skin and Systemic Diseases

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