2019
DOI: 10.1055/a-1017-5085
|View full text |Cite
|
Sign up to set email alerts
|

The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress

Abstract: Background Ifosfamide (IFO) is an alkylating agent administered against different types of malignancies. Several cases of renal injury and serum electrolytes disturbances have been reported in IFO-treated patients. Oxidative stress and mitochondrial dysfunction are suspected of being involved in the mechanism of IFO nephrotoxicity. Carnosine is a dipeptide which its antioxidant and mitochondria protecting properties have been mentioned in different experimental models. The current study aimed to evaluate the n… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
9
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
5
3

Relationship

3
5

Authors

Journals

citations
Cited by 19 publications
(10 citation statements)
references
References 31 publications
1
9
0
Order By: Relevance
“…Several studies have mentioned the positive effects of antioxidants against cholestasis [84][85][86]. N-acetyl cysteine, proline, α-lipoic acid, betaine, selenium, glycine, boldine, agmatine, and several other agents have been used to ameliorate cholestasis-induced organ injury [42,62,73,[87][88][89][90][91][92].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Several studies have mentioned the positive effects of antioxidants against cholestasis [84][85][86]. N-acetyl cysteine, proline, α-lipoic acid, betaine, selenium, glycine, boldine, agmatine, and several other agents have been used to ameliorate cholestasis-induced organ injury [42,62,73,[87][88][89][90][91][92].…”
Section: Discussionmentioning
confidence: 99%
“…Minced tissue was transported into mitochondria isolation buffer (5 ml buffer : 1 g tissue) and homogenized. The differential centrifugation method was used to isolate kidney mitochondria [26,72,73]. For this purpose, the kidney homogenate was centrifuged (1000 g, 20 min, 4°C) to pellet unbroken cells and nuclei.…”
Section: Mitochondria Isolation From the Rat Kidneymentioning
confidence: 99%
“…Briefly, 1 ml of heart tissue homogenate (10% w/v in Tris-HCl buffer, 40 mM, pH = 7.4) was added to 3 ml of TBARS assay reaction mixture (1 ml of thiobarbituric acid 0.375%, w/v, 2 ml of trichloroacetic acid 15%; w/v, and 1 ml of hydrochloric acid 12 N, pH = 2). Samples were mixed well and heated in a water bath (100°C, 45 min) [ 48 , 53 - 55 ]. Finally, n-butanol (2 ml) was added and vigorously mixed.…”
Section: Methodsmentioning
confidence: 99%
“…[94][95][96] The positive effects of CAR on mitochondrial function have been repeatedly mentioned in previous investigations. 39,[41][42][43][44][45]97 Therefore, the effects of CAR on mitochondria-facilitated ROS formation, enhancing cellular ATP levels, cellular macromolecules injury, as well as prevention of mitochondria-mediated cell death, could play a significant role in the cytoprotective properties of this peptide in CN. The antifibrotic properties of CAR have been mentioned in various experimental models.…”
Section: Figurementioning
confidence: 99%
“…It has been found that CAR administration significantly enhanced ATP production and mitigated mitochondria-mediated cell death in different experimental models. [39][40][41][42][43][44][45] All these properties make CAR as a potential candidate for the management of CN complications. The current study aimed to assess the effects of CAR administration against cholestasis-induced renal injury.…”
Section: Introductionmentioning
confidence: 99%