The Nerve Growth Factor

Levi‐Montalcini, Rita; Angeletti, Ruth Hogue; Angeletti, Pietro U.

doi:10.1016/b978-0-12-119285-3.50007-6

Cited by 140 publications

(169 citation statements)

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“…NGF and EGF concentrations also are known to be androgen dependent and levels of both are higher in adult male than in adult female SMG (10,22,27); however, serum testosterone levels remain below 1 ng/ml before 26 days gestation (14) only increasing to adult levels between 4-12 wk of age. Thus, circulating androgens are not likely to be a major factor in the marked increase in SMG NGF and EGF between 18-32 days.…”

Section: Discussionmentioning

confidence: 99%

“…We measured NGF concentrations in mouse cerebellum, cerebral Nerve growth factor (NGF) and epidermal growth factor (EGF) cortex, and brain stem from ages 2-32 days. In addition, we are found in highest concentrations in the submaxillary gland assessed mouse serum thyroxine (T4) and triiodothyronine (T3) (SMG) of the adult male mouse (13,22). Both proteins are found levels in SePerate groups of animals ranging from 5-50 days of in peritubular cells (32,35) and are released concomitantly into age.…”

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confidence: 92%

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Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

et al. 1982

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Summarybetween 11 and 32 days of age. The known increase in mouse serum testosterone to adult male levels between 4-12 wk of age Using specific and sensitive radioimmunoassa~s for may be a factor in the late increase in NGF and EGF elevations growth factor (NGF) and epidermal growth factor (EGF), we after 32 days of age. studied the developmental profde of NGF and EGF concentrations in male mouse submaxillary gland (SMG) from 2-60 days of age. We measured NGF concentrations in mouse cerebellum, cerebral Nerve growth factor (NGF) and epidermal growth factor (EGF) cortex, and brain stem from ages 2-32 days. In addition, we are found in highest concentrations in the submaxillary gland assessed mouse serum thyroxine (T4) and triiodothyronine (T3) (SMG) of the adult male mouse (13,22). Both proteins are found levels in SePerate groups of animals ranging from 5-50 days of in peritubular cells (32,35) and are released concomitantly into age. Mean SMG EGF content and concentration exceeded that saliva (16,27). ~0 t h have C-terminus arginine residues (2, 13) and of NGF between 2 and 18 days of age. At all subsequent ages, exist in SMG as high molecular weight complexes with specific however, mean NGF and EGF content and concentration were arginine esteropeptidase subunits (34). In addition, both NGF, similar. SMG NGF and EGF content were low at 2 days of age, and EGF are found in higher concentrations in male than in decreased slightly through 8 days of age, and increased exponen-female glands. The concentration of both peptides in SMG is tially after 11 days of age with three phases of increase being increased by androgens (10, 17). Bynny et al. (9) described the apparent for both proteins. In the first phase, mean SMG NGF ontogenetic profile of radioimmunoassayable SMG EGF content and EGF contents increased 2.4 and 2.3-fold respectively between from 15 days ofage through adulthood. ~l~~ and ~~~i -~~~ 11 and 18 days of age. A second phase of increase was noted (3) have traced the developmental pattern of SMG NGF concenbetween 18 and 32 days when NGF and EGF increased 9g45-and trations after 20 days using an in vitro bioassay. Murphy et al. (26) 7805-fold respectively. In phase three (32-60 days of age) more have suggested that NGF and EGF are present in equal concenmodest increases of 6.5-fold in mean NGF and EGF content were trations in mature male mouse SMG; however, simultaneous noted.measurements of SMG NGF and EGF concentrations during Cerebellar NGF on cent rations hcreased from 681 to 2241 p d postnatal development in the mouse have not been conducted. mg protein between ages 2 and 15 days and subsequently feu aIn earlier reports we have described significant concentrations plateau level of 1304 pg/mg protein by age 18 days. Cerebral of radioimmunoassayble NGF in brain tissue of adult and develcortical NGF concentrations increased steadily from 251 to 1383 oping mice (37,40) but have not developed a complete ontogenetic p d m g protein between ages 2 and 32 days, w l~r e a s brain stem profile; moreover, we have...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 92%

Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

et al. 1982

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“…Between E4 and E7, chick DRG contain progenitors whose initial survival is independent of NG,F (Ernsberger and Rohrer, 1988). As development proceeds, sensory neuron sur-viva1 can be enhanced by NGF, brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT3) (Levi-Montalcini and Angeletti, 1968;Barde et al, 1980;Lindsay et al, 1985;Rohrer et al, 1985;Ernfors et al, 1990;Hohn et al, 1990;Maisonpierre et al, 1990).…”

Section: Stem Cell Factor Is a Neurotrophicmentioning

confidence: 99%

Stem cell factor is a neurotrophic factor for neural crest-derived chick sensory neurons

1994

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We have found that stem cell factor (SCF) selectively enhances the survival of cultured embryonic chick dorsal root ganglia (DRG) neurons. Neurons grown in the presence of SCF expressed both neurofilament 150 kDa subunit and calcitonin-gene related peptide. SCF does not, however, enhance the survival of parasympathetic, placode-derived sensory or sympathetic neurons in culture. Combining SCF with brain-derived neurotrophic factor or neurotrophin-3, but not with NGF, maintains more neurons than either factor alone, suggesting that these factors have partially overlapping activities. SCF preferentially rescues small neurons from the DRG. Labeling studies with bromodeoxyuridine indicate that the neurons sustained by SCF are not differentiating from a dividing progenitor.

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“…Among these, neurotrophins (NTs) belong to a well-characterized family including nerve growth factor (NGF) -which was the first GF to be identified. 1,2 Although the term trophic is widely used to indicate, as previously mentioned, a generalized 'nutritional' action mediated through several metabolic pathways, more detailed and in-depth experiments have indicated that this term is often too broad or ambiguous.…”

Section: Trophic Tropic and Nerve Growth-promoting Activity Of Ngfmentioning

confidence: 99%

Does the term ‘trophic’ actually mean anti-amyloidogenic? The case of NGF

et al. 2010

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The Nerve Growth Factor

Cited by 140 publications

References 60 publications

Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

Stem cell factor is a neurotrophic factor for neural crest-derived chick sensory neurons

Does the term ‘trophic’ actually mean anti-amyloidogenic? The case of NGF

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