The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity

Hondermarck, Hubert; Huang, Pearl S.; Wagner, John A.

doi:10.1096/fba.2021-00080

Cited by 5 publications

(7 citation statements)

References 81 publications

(165 reference statements)

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“…Among the identified key miRNAs, brain- or liver-predominant miRNAs, such as miR-125a-3p and miR-122-5p, were consolidated, suggesting that the brain (or neuronal system) and the liver could act as control towers for circulating miRNomes. Because recent studies pointed out that a liver–brain–gut neural arc plays an important role in cancer progression and inflammation ( 32 , 33 ), the liver and brain might supervise the malignant status of all organs in the body. Although brain-derived miRNAs have been studied as biomarkers for neurological disorders, alterations in the circulating levels of these miRNAs in cancer patients have not been investigated in detail.…”

Section: Discussionmentioning

confidence: 99%

Prediction of tissue-of-origin of early stage cancers using serum miRNomes

Matsuzaki

Kato

Oono

et al. 2022

JNCI Cancer Spectrum

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Background Non-invasive detection of early-stage cancers with accurate prediction of tumor tissue-of-origin could improve patient prognosis. Because miRNA profiles differ between organs, circulating miRNomics represent a promising method for early detection of cancers, but this has not been shown conclusively. Methods A serum miRNome-based classifier was evaluated for its ability to discriminate cancer types using advanced machine learning. The training set comprised 7,931 serum samples from patients with 13 types of solid cancers and 5,013 non-cancer samples. The validation set consisted of 1,990 cancer and 1,256 non-cancer samples. The contribution of each miRNA to the cancer-type classification was evaluated and those with a high contribution were identified. Results Cancer type was predicted with an accuracy of 0.88 (95% CI, 0.87–0.90) in all stages and an accuracy of 0.90 (95% CI, 0.88–0.91) in resectable stages (Stages 0–II). The F1-score for the discrimination of the 13 cancer types was 0.93. Optimal classification performance was achieved with at least 100 miRNAs that contributed the strongest to accurate prediction of cancer type. Assessment of tissue expression patterns of these miRNAs suggested that miRNAs secreted from the tumor environment could be used to establish cancer type-specific serum miRNomes. Conclusions This study demonstrates that large-scale serum miRNomics in combination with machine learning could lead to the development of a blood-based cancer classification system. Further investigations of the regulating mechanisms of the miRNAs that contributed strongly to accurate prediction of cancer type could pave the way for the clinical use of circulating miRNA diagnostics.

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Section: Discussionmentioning

confidence: 99%

Prediction of tissue-of-origin of early stage cancers using serum miRNomes

Matsuzaki

Kato

Oono

et al. 2022

JNCI Cancer Spectrum

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“…Native bone vasculature and remodeling processes are involved in driving breast cancer cell engraftment in bone [39]. The sensory denervation efficacy of capsaicin injection [18,23]…”

Section: Innervation Promotes Breast Cancer Progressionmentioning

confidence: 99%

The tumor-nerve circuit in breast cancer

Cui

Jiang

Zhang

et al. 2023

Cancer Metastasis Rev

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It is well established that innervation is one of the updated hallmarks of cancer and that psychological stress promotes the initiation and progression of cancer. The breast tumor environment includes not only fibroblasts, adipocytes, endothelial cells, and lymphocytes but also neurons, which is increasingly discovered important in breast cancer progression. Peripheral nerves, especially sympathetic, parasympathetic, and sensory nerves, have been reported to play important but different roles in breast cancer. However, their roles in the breast cancer progression and treatment are still controversial. In addition, the brain is one of the favorite sites of breast cancer metastasis. In this review, we first summarize the innervation of breast cancer and its mechanism in regulating cancer growth and metastasis. Next, we summarize the neural-related molecular markers in breast cancer diagnosis and treatment. In addition, we review drugs and emerging technologies used to block the interactions between nerves and breast cancer. Finally, we discuss future research directions in this field. In conclusion, the further research in breast cancer and its interactions with innervated neurons or neurotransmitters is promising in the clinical management of breast cancer.

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“…The NGF–TrkA signalling pathway has great potential as a therapeutic target, and the treatment approach consists in using antibodies [ 10 , 14 ]. By blocking the tyrosine kinase receptor (TRK) using pharmacological inhibitors, it is possible to relent tumour advancement ( Figure 4 ) [ 68 ].…”

Section: Conventional and Experimental Treatments For Pnimentioning

confidence: 99%

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance

Selvaggi

Melchiorre

Casari

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma is one of the most threatening solid malignancies. Molecular and cellular mediators that activate paracrine signalling also regulate the dynamic interaction between pancreatic cancer cells and nerves. This reciprocal interface leads to perineural invasion (PNI), defined as the ability of cancer cells to invade nerves, similar to vascular and lymphatic metastatic cascade. Targeting PNI in pancreatic cancer might help ameliorate prognosis and pain relief. In this review, the modern knowledge of PNI in pancreatic cancer has been analysed and critically presented. We focused on molecular pathways promoting cancer progression, with particular emphasis on neuropathic pain generation, and we reviewed the current knowledge of pharmacological inhibitors of the PNI axis. PNI represents a common hallmark of PDAC and correlates with recurrence, poor prognosis and pain in pancreatic cancer patients. The interaction among pancreatic cancer cells, immune cells and nerves is biologically relevant in each stage of the disease and stimulates great interest, but the real impact of the administration of novel agents in clinical practice is limited. It is still early days for PNI-targeted treatments, and further advanced studies are needed to understand whether they could be effective tools in the clinical setting.

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The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity

Cited by 5 publications

References 81 publications

Prediction of tissue-of-origin of early stage cancers using serum miRNomes

Prediction of tissue-of-origin of early stage cancers using serum miRNomes

The tumor-nerve circuit in breast cancer

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance

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