The neural circuitry supporting goal maintenance during cognitive control: a comparison of expectancy AX-CPT and dot probe expectancy paradigms

López-García, Pilar; Lesh, Tyler A.; Salo, Taylor; Deanna, M; MacDonald, Angus W.; Gold, James M.; Ragland, J. Daniel; Strauss, Milton E.; Silverstein, Steven M.; Carter, Cameron S.

doi:10.3758/s13415-015-0384-1

Cited by 65 publications

(64 citation statements)

References 42 publications

(83 reference statements)

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“…Research on Cognitive Systems has been considerable and diverse, with eighteen studies published on four of the six constructs within the domain (e.g., Cognitive Control: Lopez-Garcia et al (2016); Perception: Silverstein et al (2015); Attention: Kleinman et al (2015); and Working Memory: Francazio and Flessner (2015)). To elaborate on one example, Chan et al (2015) demonstrated how a standard performance-monitoring event-related potential paradigm can be used within an RDoC framework to examine Cognitive Control and Performance Monitoring systems.…”

Section: Resultsmentioning

confidence: 99%

Six Years of Research on the National Institute of Mental Health’s Research Domain Criteria (RDoC) Initiative: A Systematic Review

Carcone

Ruocco

2017

Front. Cell. Neurosci.

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Six years have passed since the National Institute of Mental Health (NIMH) in the United States launched the Research Domain Criteria (RDoC) initiative. The RDoC introduces a framework for research on the biology of mental illness that integrates research findings across multiple levels of information. The framework outlines constructs that represent specific quantifiable dimensions of behavior (e.g., responses to acute threat, cognitive control) and corresponding units of analysis that can be used to study the constructs, beginning at the levels of genes, molecules, cells, circuits and physiology, and moving up to behaviors and self-reports. In this systematic review, a literature search was conducted to synthesize empirical research published since the proposal of the framework that incorporated the RDoC. Forty-eight peer-reviewed scholarly articles met eligibility criteria for the review. Studies differed according to whether they analyzed RDoC constructs and units of analysis within vs. between clinically-diagnosed and non-psychiatric samples. The most commonly studied constructs were subsumed within the domains of Negative Valence Systems, Positive Valence Systems and Cognitive Systems, providing initial results which primarily connected genetics, brain circuits and physiology research findings with behavior and self-reports. Prospects for future research adopting the RDoC matrix and utilizing a dimensional approach to studying the biology of mental illness are discussed.

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Section: Resultsmentioning

confidence: 99%

Six Years of Research on the National Institute of Mental Health’s Research Domain Criteria (RDoC) Initiative: A Systematic Review

Carcone

Ruocco

2017

Front. Cell. Neurosci.

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“…Second, behavioral results indicated that similar relationships existed between both A and B cue RT with an independent measure of working memory, suggesting that both cues utilized proactive cognitive control to some degree. Finally, variations in task design (e.g., longer inter‐stimulus intervals, differences in the frequency of BX probes) also influence how participants utilize cue information (Lesh et al, ; Lopez‐Garcia et al, ) and may ultimately alter DLPFC recruitment.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, a significant inverse relationship was found between differential cuerelated activation in the default mode network (DMN) and only the L Cblm. Asterisks denote significant relationships information (Lesh et al, 2013;Lopez-Garcia et al, 2016) and may ultimately alter DLPFC recruitment.…”

Section: Both Probes Followingmentioning

confidence: 99%

Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex

Ryman

Shaikh

Shaff

et al. 2018

Human Brain Mapping

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The role of ventral versus dorsolateral prefrontal regions in instantiating proactive and reactive cognitive control remains actively debated, with few studies parsing cue versus probe‐related activity. Rapid sampling (460 ms), long cue–probe delays, and advanced analytic techniques (deconvolution) were therefore used to quantify the magnitude and variability of neural responses during the AX Continuous Performance Test (AX‐CPT; N = 46) in humans. Behavioral results indicated slower reaction times during reactive cognitive control (AY trials) in conjunction with decreased accuracy and increased variability for proactive cognitive control (BX trials). The anterior insula/ventrolateral prefrontal cortex (aI/VLPFC) was commonly activated across comparisons of both proactive and reactive cognitive control. In contrast, activity within the dorsomedial and dorsolateral prefrontal cortex was limited to reactive cognitive control. The instantiation of proactive cognitive control during the probe period was also associated with sparse neural activation relative to baseline, potentially as a result of the high degree of neural and behavioral variability observed across individuals. Specifically, the variability of the hemodynamic response function (HRF) within motor circuitry increased after the presentation of B relative to A cues (i.e., late in HRF) and persisted throughout the B probe period. Finally, increased activation of right aI/VLPFC during the cue period was associated with decreased motor circuit activity during BX probes, suggesting a possible role for the aI/VLPFC in proactive suppression of neural responses. Considered collectively, current results highlight the flexible role of the VLPFC in implementing cognitive control during the AX‐CPT task but suggest large individual differences in proactive cognitive control strategies.

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“…Collectively, these data indicate that reduced PC DAT functioning drives impaired attentional performance of participants with BD mania, and also possibly children with ADHD. Given the importance of parietal function across CPTs, it is also possible that altered PC function negatively impacts other disorders such as schizophrenia or additional phases of BD such as depression. Future studies should address this limitation and include other populations and phases of BD illness.…”

Section: Discussionmentioning

confidence: 99%

“…69 Collectively, these data indicate that reduced PC DAT functioning drives impaired attentional performance of participants with BD mania, and also possibly children with ADHD. Given the importance of parietal function across CPTs, 70 Several limitations exist within these studies. One is that while the majority of people with BD tested were female, the mice tested were only male.…”

Section: Bd Mania Patients Exhibited a Similar Profile Of Poor Attentionmentioning

confidence: 99%

Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter‐deficient mice using the 5‐choice CPT

et al. 2019

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Objectives Bipolar disorder (BD) is a debilitating psychiatric illness affecting 2%‐5% of the population. Although mania is the cardinal feature of BD, inattention and related cognitive dysfunction are observed across all stages. Since cognitive dysfunction confers poor functional outcome in patients, understanding the relevant neural mechanisms remains key to developing novel‐targeted therapeutics. Methods The 5‐choice continuous performance test (5C‐CPT) is a mouse and fMRI‐compatible human attentional task, requiring responding to target stimuli while inhibiting responding to nontarget stimuli, as in clinical CPTs. This task was used to delineate systems‐level neural deficits in BD contributing to inattentive performance in human subjects with BD as well as mouse models with either parietal cortex (PC) lesions or reduced dopamine transporter (DAT) expression. Results Mania BD participants exhibited severe 5C‐CPT impairment. Euthymic BD patients exhibited modestly impaired 5C‐CPT. High impulsivity BD subjects exhibited reduced PC activation during target and nontarget responding compared with healthy participants. In mice, bilateral PC lesions impaired both target and nontarget responding. In the DAT knockdown mouse model of BD mania, knockdown mice exhibited severely impaired 5C‐CPT performance versus wildtype littermates. Conclusions These data support the role of the PC in inattention in BD—specifically regarding identifying the appropriate response to target vs nontarget stimuli. Moreover, the findings indicate that severely reduced DAT function/hyperdopaminergia recreates the attentional deficits observed in BD mania patients. Determining the contribution of DAT in the PC to attention may provide a future target for treatment development.

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The neural circuitry supporting goal maintenance during cognitive control: a comparison of expectancy AX-CPT and dot probe expectancy paradigms

Cited by 65 publications

References 42 publications

Six Years of Research on the National Institute of Mental Health’s Research Domain Criteria (RDoC) Initiative: A Systematic Review

Six Years of Research on the National Institute of Mental Health’s Research Domain Criteria (RDoC) Initiative: A Systematic Review

Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex

Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter‐deficient mice using the 5‐choice CPT

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