The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis

Wang, Xinyi; Wang, Haiyun; Ye, Zhenghui; Ding, Guofei; Li, Fengli; Ma, Ji; Hua, Wei

doi:10.18632/aging.102918

Cited by 21 publications

(16 citation statements)

References 40 publications

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“…Our results indicate that the concentration of BDNF in peripheral blood increased significantly in all patients who participated in 12-week sport stacking, and the concentration of IGF-1 in peripheral blood only increased significantly in patients with MCI. Consistent with the results of our study, previous research has suggested that multicomponent exercise could increase BDNF concentrations (Wang et al, 2020 ), and physical exercise has been shown to increase IGF-1 levels in patients with MCI (Baker et al, 2010 ). Exercise-related upregulation of BDNF and IGF-1 may help to offset the age-related decline in synaptogenesis, neurogenesis, angiogenesis, synaptic plasticity, and learning and memory, thus making the brain more flexible in dealing with age-related structural and functional neurodegeneration (Cotman and Berchtold, 2002 , 2007 ).…”

Section: Discussionsupporting

confidence: 93%

Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial

Yang

Zhang

Liu

et al. 2022

Front. Aging Neurosci.

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ObjectiveTo investigate the effects of sport stacking on the overall cognition and brain function in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI).MethodsA single-blind randomized controlled design was performed using sport stacking for 30 min, 5 days/week for 12 weeks. Forty-eight subjects with mild AD or MCI were randomly divided into the sport stacking group (T-mAD = 12, T-MCI = 12) and the active control group (C-mAD = 11, C-MCI = 13). Auditory Verbal Learning Test (AVLT), Alzheimer's Disease Cooperative Study–Activities of Daily Living scale (ADCS-ADL), Geriatric Depression Scale (GDS-30), and Pittsburgh Sleep Quality Index (PSQI) were performed, the level of amyloid β-protein-40 (Aβ-40), Aβ-42, brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1(IGF-1), tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6), and soluble trigger receptor expressed on myeloid cells 2 (sTREM2) in plasma were tested, and brain functional connectivity in resting state and activation under finger movement task were analyzed by functional near-infrared spectroscopy (fNIRS).ResultsThirty-nine patients completed the trial. After 4 weeks, we found a significant increase in AVLT score in T-MCI (6.36 ± 5.08 vs. −1.11 ± 4.23, p = 0.004), and T-mAD group (4.60 ± 4.77 vs. −0.11 ± 2.89, p = 0.039). After 12 weeks, there was a significantly improved in AVLT (9.64 ± 4.90 vs. −0.33 ± 6.10, p = 0.002) and ADCS-ADL (3.36 ± 3.59 vs. −1.89 ± 2.71, p = 0.003) in T-MCI. There was a significant improvement in AVLT (5.30 ± 5.42 vs. 0.44 ± 2.40) in T-mAD (p < 0.05). Plasma levels of BDNF were upregulated in both T-MCI and T-mAD, and IGF-1 increased in T-MCI (P < 0.05) compared to the control groups. The functional connectivity in MCI patients between DLPFC.R and SCA.R, SMA.L, and SCA.R was decreased. In contrast, in mAD patients, the brain regional function connection was increased between DLPFC.R and Broca's.L. The activation of channel 36 located in the left primary somatosensory cortex was significantly increased after 12-week training, which was correlated with the improved AVLT and the increase of BDNF.ConclusionOur findings suggested that sport stacking is effective for patients with MCI and mild AD, possibly through increasing the expression of neuroprotective growth factors and enhancing neural plasticity to improve neurocognitive performance.Clinical Trial Registrationhttps://www.ClinicalTrials.gov, ChiCTR.org.cn, identifier: ChiCTR-2100045980.

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Section: Discussionsupporting

confidence: 93%

Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial

Yang

Zhang

Liu

et al. 2022

Front. Aging Neurosci.

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“…Our results showed that among the patients who developed the disease in winter, the subjects aged 15–35 years had a higher risk for bipolar depression than for unipolar depression as compared to subjects aged 35–55 years and those older than 55 years. This indicates that young patients who develop depression in winter are highly suspected of bipolar depression, but the adults and elderly patients who develop depression in winter are suspected of unipolar depression, which are consistent with the descriptions in DSM and clinical experience ( 12 – 14 ).…”

Section: Discussionsupporting

confidence: 86%

Analysis of Seasonal Clinical Characteristics in Patients With Bipolar or Unipolar Depression

et al. 2022

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This study was to investigate the characteristics of seasonal symptoms and non-enzymatic oxidative stress in the first hospitalized patients with bipolar and unipolar depression, aiming to differentiate bipolar depression from unipolar depression and reduce their misdiagnosis. A total of 450 patients with bipolar depression and 855 patients with depression were included in the present study. According to the season when the patients were admitted to the hospital due to the acute onset of depression, they were further divided into spring, summer, autumn and winter groups. According to the characteristics of symptoms of bipolar disorder in the DSM-5, the characteristic symptoms of bipolar disorder were collected from the medical record information, and clinical biochemical indicators that can reflect the oxidative stress were also recorded. The seasonal risk factors in patients with bipolar or unipolar depression were analyzed. The relationship of age and gender with the bipolar or unipolar depression which attacked in winter was explored. There were significant differences between groups in the melancholic features, atypical features and conjugated bilirubin in spring. In summer, there were significant differences between groups in the melancholic features, uric acid and conjugated bilirubin. In autumn, there were marked differences between groups in melancholic features, anxiety and pain, atypical features, uric acid, total bilirubin, conjugated bilirubin and albumin. In winter, the conjugated bilirubin and prealbumin were significantly different between two groups. The melancholic features and uric acid that in summer as well as melancholic features, uric acid and total bilirubin in autumn were the seasonal independent risk factors for the unipolar depression as compared to bipolar depression. In winter, significant difference was noted in the age between two groups. In conclusion, compared with patients with unipolar depression, patients with bipolar depression have seasonal characteristics. Clinical symptoms and indicators of oxidative stress may become factors for the differentiation of seasonal unipolar depression from bipolar depression. Young subjects aged 15–35 years are more likely to develop bipolar depression in winter.

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“…58,59 Even in the case of dementia, exercise science has established a body of both human and animal research demonstrating a strong role for aerobic activity. [60][61][62][63][64][65] The relationship between exercise in cognitive loss prevention remains less clear, but it is reasonable to presume that exercise promotion is at the very least prudent in mild cognitive impairment (MCI) and dementia. 65,66 In recent years, aquatic exercise has been promoted as a useful exercise option in both MCI and dementia.…”

Section: Aquatic Therapy Use In Dementiamentioning

confidence: 99%

“…The role of exercise in the preservation and improvement of cognitive function is becoming well‐established science however 58,59 . Even in the case of dementia, exercise science has established a body of both human and animal research demonstrating a strong role for aerobic activity 60‐65 . The relationship between exercise in cognitive loss prevention remains less clear, but it is reasonable to presume that exercise promotion is at the very least prudent in mild cognitive impairment (MCI) and dementia 65,66 .…”

Section: Aquatic Therapy Use In Dementiamentioning

confidence: 99%

Aquatic Therapy in Contemporary Neurorehabilitation: An Update

Becker

2020

PM&R

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Aquatic therapy has been used extensively in a number of neurologic diseases and pathologies. This review describes disease-specific rehabilitative applications for this population. Recent research has offered scientific support for use in common neurological diseases that are part of rehabilitative practice, and very recent findings may create even firmer support for its use in these as well as other conditions. Stroke, Parkinsonism, and multiple sclerosis are areas that have recently received a significant number of published studies. Dementia is another area that has been more recently studied and received basic science support. Cerebral palsy has also had recent supportive evidence published. Available literature is reviewed to create a more evidence-based support for the use of aquatic therapy in neurorehabilitation.

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The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis

Cited by 21 publications

References 40 publications

Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial

Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial

Analysis of Seasonal Clinical Characteristics in Patients With Bipolar or Unipolar Depression

Aquatic Therapy in Contemporary Neurorehabilitation: An Update

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