This work investigates the determinants of patenting at Italian universities. We test the effect of public and external funds, in terms of commercial activity by universities, towards the propensity of universities to file patents at the European Patent Office. We then estimate the effect of several variables referring to the contextual characteristics of both university and localisation. The results suggest that, while in the southern regions of Italy commercial income bears a negative effect on the patenting activity of universities, in the other regions we register an important positive effect. We moreover find that the adoption of internal university regulations relating to patenting and the fact of being embedded in an innovative region are factors that exert a positive influence on the university rate of application for patents