2002
DOI: 10.1124/mol.61.5.1222
|View full text |Cite
|
Sign up to set email alerts
|

The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central Nervous System

Abstract: In this study, the patch-clamp technique was used to determine the effects of galantamine, a cholinesterase inhibitor and a nicotinic allosteric potentiating ligand (APL) used for treatment of Alzheimer's disease, on synaptic transmission in brain slices. In rat hippocampal and human cerebral cortical slices, 1 microM galantamine, acting as a nicotinic APL, increased gamma-aminobutyric acid (GABA) release triggered by 10 microM acetylcholine (ACh). Likewise, 1 microM galantamine, acting as an APL on presynapti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

8
111
0
3

Year Published

2002
2002
2012
2012

Publication Types

Select...
3
3

Relationship

2
4

Authors

Journals

citations
Cited by 158 publications
(122 citation statements)
references
References 31 publications
8
111
0
3
Order By: Relevance
“…At concentrations ranging from 1 to 10 M physostigmine potentiated ACh-induced activation of ␣4␤2 and ␣4␤4 nAChRs ectopically expressed in Xenopus oocytes, whereas at concentrations higher than 10 M physostigmine caused significant blockade of the receptors . In agreement with the concept that physostigmine at high concentrations acts as an open-channel blocker on nAChRs (Shaw et Graph depicting galantamine-induced potentiation of ACh-triggered GABA release in human cerebral cortical slices, an effect that is sensitive to blockade by FK-1 (for details regarding data analysis see Santos et al, 2002). (C) Graph showing that galantamine-induced facilitation of glutamatergic transmission in rat hippocampal slices is also blocked by FK-1 (for details regarding data analysis see Santos et al, 2002).…”
Section: Exogenous Unconventional Nachr Ligands That Modulate Receptsupporting
confidence: 82%
See 4 more Smart Citations
“…At concentrations ranging from 1 to 10 M physostigmine potentiated ACh-induced activation of ␣4␤2 and ␣4␤4 nAChRs ectopically expressed in Xenopus oocytes, whereas at concentrations higher than 10 M physostigmine caused significant blockade of the receptors . In agreement with the concept that physostigmine at high concentrations acts as an open-channel blocker on nAChRs (Shaw et Graph depicting galantamine-induced potentiation of ACh-triggered GABA release in human cerebral cortical slices, an effect that is sensitive to blockade by FK-1 (for details regarding data analysis see Santos et al, 2002). (C) Graph showing that galantamine-induced facilitation of glutamatergic transmission in rat hippocampal slices is also blocked by FK-1 (for details regarding data analysis see Santos et al, 2002).…”
Section: Exogenous Unconventional Nachr Ligands That Modulate Receptsupporting
confidence: 82%
“…In agreement with the concept that physostigmine at high concentrations acts as an open-channel blocker on nAChRs (Shaw et Graph depicting galantamine-induced potentiation of ACh-triggered GABA release in human cerebral cortical slices, an effect that is sensitive to blockade by FK-1 (for details regarding data analysis see Santos et al, 2002). (C) Graph showing that galantamine-induced facilitation of glutamatergic transmission in rat hippocampal slices is also blocked by FK-1 (for details regarding data analysis see Santos et al, 2002). (D) A simplified neuronal circuitry of tonic nAChR modulation of the activity of glutamatergic axons synapsing onto a CA1 pyramidal neuron in the hippocampus.…”
Section: Exogenous Unconventional Nachr Ligands That Modulate Receptsupporting
confidence: 82%
See 3 more Smart Citations