2014
DOI: 10.1016/j.neulet.2014.03.054
|View full text |Cite
|
Sign up to set email alerts
|

The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
9
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 18 publications
(9 citation statements)
references
References 21 publications
0
9
0
Order By: Relevance
“…However, studies of animals exposed to CO have reported demyelination and axonal degeneration in the hippocampus due to the degradation of myelin basic protein. [ 6 ] The latter results from decreasing neurons and nicotinic acetylcholine receptor levels, [ 7 ] and the reduction of acetylcholine levels in the frontal lobe. [ 8 ] A previous study also reported that an immunologic mechanism may be associated with cognitive dysfunction caused by delayed encephalopathy due to CO poisoning.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…However, studies of animals exposed to CO have reported demyelination and axonal degeneration in the hippocampus due to the degradation of myelin basic protein. [ 6 ] The latter results from decreasing neurons and nicotinic acetylcholine receptor levels, [ 7 ] and the reduction of acetylcholine levels in the frontal lobe. [ 8 ] A previous study also reported that an immunologic mechanism may be associated with cognitive dysfunction caused by delayed encephalopathy due to CO poisoning.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is thought that AchEI strengthens hippocampal acetylcholinergic neuron function such that delayed neuronal death by CO reactivation is prevented. [ 7 ] In addition, AchEIs demonstrate pleiotropic effects. They are known to act as neuroprotective agents by exerting antiapoptotic effects in cortical and hippocampal neurons, elevating Bcl-2 expression, stimulating nicotinic acetylcholine receptors, activating the PI-3K/Akt pathway, and suppressing glycogen synthase kinase-3.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Our case one showed difficulty in understanding, expression, memory, character, and spatial orientation. The mechanism may be related to the affection of nicotinic cholinergic system after DEACMP [18]. Recent studies have confirmed that acetylcholinesterase inhibitors such as donepezil or galanthamine could alleviate cognitive impairment associated with DEACMP.…”
Section: Discussionmentioning
confidence: 99%
“…The put-forward mechanisms for delayed neuropsychological sequelae to acute CO poisoning upon which HBO therapy exhibits its beneficial effects include cholinergic neuronal dysfunction (36), changes in redox homeostasis and antioxidant status (37), mitochondrial dysfunction (38), immune-mediated injury (39), degradation of myelin basic protein (40), and delayed inflammation (41). These lines of evidence all point to protection against necrotic or apoptotic cell death for the beneficial effect of HBO.…”
Section: Discussionmentioning
confidence: 99%