The Nonsynonymous Single-Nucleotide Polymorphisms in Codon 31 of p21 Gene and the Susceptibility to Cervical Cancer in Chinese Women

Tian, Qifang; Lü, Weiguo; Chen, Huaizeng; Ye, Feng; Xie, Xing

doi:10.1111/igc.0b013e3181a8b950

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Some other methods were also applied, such as direct sequencing, Taqman, and SNaPshot (Table 1). Overall, most studies indicated that the distribution of genotypes in controls was consistent with HWE with the exception of 6 studies[19],[26],[40],[43],[47],[59].…”

Section: Resultsmentioning

confidence: 99%

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Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis

Ma¹,

Zhou²,

Wei³

et al. 2011

Chin J Cancer

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P21 (CDKN1A), a key cell cycle regulatory protein that governs cell cycle progression from G1 to S phase, can regulate cell proliferation, growth arrest, and apoptosis. The Ser31Arg polymorphism is located in the highly conserved region of p21 and may encode functionally distinct proteins. Although many epidemiological studies have been conducted to evaluate the association between the p21 Ser31Arg polymorphism and cancer risk, the findings remain conflicting. This meta-analysis with 33 077 cases and 45 013 controls from 44 published case-control studies showed that the variant homozygous 31Arg/Arg genotype was associated with an increased risk of numerous types of cancers in a random-effect model (homozygote comparison: OR = 1.17, 95% CI = 0.99 to 1.37, P = 0.0002 for the heterogeneity test; recessive model comparison: OR = 1.16, 95% CI = 1.01 to 1.33, P = 0.0001 for the heterogeneity test). Stratified analysis revealed that increased cancer risk associated with the 31Arg/Arg genotype remained significant in subgroups of colorectal cancer, estrogen-related cancer, Caucasians, population-based studies, studies with matching information or a larger sample size. Heterogeneity analysis showed that tumor type contributed to substantial between-study heterogeneity (recessive model comparison: χ2 = 21.83, df = 7, P = 0.003). The results from this large-sample sized meta-analysis suggest that the p21 31Arg/Arg genotype may serve as a potential marker for increased cancer risk.

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Section: Resultsmentioning

confidence: 99%

“…The leave-one-out sensitivity analysis indicated that no single study changed the pooled ORs qualitatively. Furthermore, the exclusion of 6 studies [19],[28],[40],[43],[47],[59], whose genotype distributions deviated from HWE, did not affect the results of the meta-analysis (OR = 1.16, 95% CI = 1.01 to 1.34, P = 0.0004).…”

Section: Resultsmentioning

confidence: 99%

Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis

Ma¹,

Zhou²,

Wei³

et al. 2011

Chin J Cancer

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“…20,26,27 It is widely believed that deviation from HWE may be due to genetic reasons including nonrandom mating or the alleles reflect recent mutations that have not reached equilibrium, as well as methodological reasons including biased selection of subjects from the population or genotyping errors. 46,47 Despite of the reasons of disequilibrium, the results of genetic association studies might be spurious if the distribution of genotypes in the control groups were not in HWE.…”

Section: Discussionmentioning

confidence: 99%

“…All these studies indicated that the distribution of genotypes in the controls was consistent with HWE, except for 3 studies. 20,26,27 Quantitative Synthesis Table 2 lists the main results of this meta-analysis, and Figure 1 shows the association of CC risk with p21 polymorphism Ser31Arg in the recessive model. Overall, the variant genotypes (Arg/Arg and Arg/Ser) of Ser31Arg were not associated with CC risk, when compared with the wild- On the basis of the potential underestimation of the true effect of the polymorphism on the CC risk, we stratified these studies according to country (China, Korea, or other), matched controls (yes or not), study sample size (e200 or 9200 subjects), and HWE in the controls (yes or not).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

P21 Ser31Arg Polymorphism and Cervical Cancer Risk: A Meta-Analysis

Liu

Tan

et al. 2011

Int J Gynecol Cancer

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“…Many groups have attempted to investigate the association between CDKN1A c.93C>A and cervical cancer risk, and highly conflicting results have been obtained thus far. For example, even in the same population, some studies showed that the A allele was associated with increased cervical cancer susceptibility [121], but some others demonstrated a decreased susceptibility associated with the same allele [122,123]. It was not entirely clear as to how the polymorphism affect cervical cancer susceptibility, but it was hypothesized that the polymorphism could affect the DNA binding affinity, and therefore functionality, of the protein.…”

Section: Cdkn1amentioning

confidence: 99%

Genetic susceptibility to cervical cancer: role of common polymorphisms in apoptosis-related genes

Tan

Ankathil

2015

Tumor Biol.

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Cervical cancer is a common malignancy which poses a significant health burden among women, especially those living in the developing countries. Although human papillomavirus (HPV) infection has been unequivocally implicated in the etiopathogenesis of the cancer, it alone is not adequate to contribute to the malignant transformation of cervical cells. Most HPV infections regress spontaneously, and only a small proportion of women have persistent infections which eventually lead to malignancy. This suggests that interplays between HPV infection and other cofactors certainly exist during the process of cervical carcinogenesis, which synergistically contribute to the differential susceptibility of an individual to the malignancy. Undoubtedly, host genetic factors represent a major element involved in such a synergistic interaction, and accumulating evidence suggests that polymorphisms in apoptosis-related genes play an important role in the genetic susceptibility to cervical cancer. This review consolidates the recent literatures on the role of common polymorphisms in apoptosis-related genes in genetic susceptibility to cervical cancer.

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The Nonsynonymous Single-Nucleotide Polymorphisms in Codon 31 of p21 Gene and the Susceptibility to Cervical Cancer in Chinese Women

Abstract: p21 Codon 31 with AGA (Arg) allele is a genetic risk factor of cervical SCC, and the increased risk is probably not caused by increasing host susceptibility to HR-HPV infection.

Cited by 14 publications

References 16 publications

Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis

Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis

P21 Ser31Arg Polymorphism and Cervical Cancer Risk: A Meta-Analysis

Genetic susceptibility to cervical cancer: role of common polymorphisms in apoptosis-related genes

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