The "not so good" thyroid cancer: a scoping review on risk factors associated with anxiety, depression and quality of life

Alexander, Kyle; Lee, S; Georgiades, Stelios; Constantinou, Constantina

doi:10.25122/jml-2022-0204

Cited by 8 publications

(4 citation statements)

References 77 publications

(251 reference statements)

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“…К тому же, в связи с более лабильными процессами физиологической регуляции гипоталамо-гипофизарной оси, прирост ТТГ в ответ на отмену ЛТ4 является более быстрым по сравнению со взрослыми пациентами, что в среднем требует около двух недель отмены тиреоидных гормонов. Однако имеются исследования, свидетельствующие о вероятной ассоциации гипотиреоза у детей с ухудшением показателей липидного профиля, прироста печеночных ферментов, креатинина, увеличением висцерального жира, что должно быть принято во внимание в индивидуальном порядке [32][33][34][35]. Вероятно, потенцирование нежелательных явлений и снижение качества жизни связано как с длительностью, так и с выраженностью гипотиреоза [36].…”

Section: влияние транзиторного гипотиреоза на изменения качества жизн...unclassified

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Reinberg,

Kiyaev,

Chernikov

et al. 2024

Clin Exp Thyroid

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Differentiated thyroid cancer (DTC) is one of the most common malignancies within the endocrine system, with a progressively increasing incidence over recent decades. In the structure of DTC, occurrence in the pediatric age group is relatively rare and is associated with excellent prognoses in terms of disease-specific survival. However, the prevalence of advanced disease in children and the frequency of recurrences present interdisciplinary teams with questions regarding the optimal management approach for such patients, focusing not on achieving disease eradication but preserving and maintaining quality of life. Notably, the presence of oncological pathology, coupled with fluctuations in thyroid hormone levels due to therapeutic interventions, underscores the importance of maintaining psychological and physiological well-being that are affected by the increased frequency of anxiety and depressive symptoms in children and their parents, as well as cognitive and physical functioning. These symptoms may exacerbate against the backdrop of hypothyroidism and directly correlate with TSH levels. To maintain quality of life during the period of dynamic observation and risk group re-stratification, we proposed a method of reduced thyroid hormone doses as an alternative to discontinuing thyroid hormones to assess stimulated thyroglobulin when reaching a threshold TSH level >30 mIU/L. The method was implemented in 2 pediatric patients, showing positive outcomes in terms of absence of hypothyroidism-related complaints, preservation of free thyroid hormone fractions, achievement of adequate target TSH levels, and informative tumor marker indicators. The results of our study underscore the importance of an individualized approach to the management of children with DTC and demonstrate the potential effectiveness of the reduced dose method in maintaining the quality of life of these patients. Further research and clinical observations are necessary for a deeper understanding of the applicability of this method and its impact on longterm outcomes.

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Section: влияние транзиторного гипотиреоза на изменения качества жизн...unclassified

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Reinberg,

Kiyaev,

Chernikov

et al. 2024

Clin Exp Thyroid

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“…Generally, various endocrine conditions (from pituitary and adrenal tumors to thyroid malignancies and neuroendocrine neoplasia up to polycystic ovary syndrome or women with infertility seeking to conceive, etc.) had been reported to impact QoL despite not routinely using them in everyday practice [106][107][108][109][110][111].…”

Section: Longitudinal Data On Php: Should Qol Assessment Find Its Way?mentioning

confidence: 99%

Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism

et al. 2023

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Tumors of the parathyroid glands, when associated with PTH (parathyroid hormone) excess, display a large area of complications; in addition to the classical clinical picture of primary hyperparathyroidism (PHP), a complex panel of other symptoms/signs can be identified, including memory and cognitive impairment, chronic asthenia/fatigue, reduced muscle functionality, depressive mood, non-specific bone pain, and loss of sleep quality. The perception of quality of life (QoL) can be supplementarily enhanced by their progressive onset, which makes many patients not be fully aware of them. Their improvement was reported very early after parathyroidectomy (PTx), yet the level of statistical evidence does not qualify these non-classical elements as standalone indications for PTx. Our objective is introducing an up-to-date on QoL scores with regards to the patients diagnosed with PHP, particularly taking into consideration PHP management from baseline to post-operatory outcome, including in cases with multiple endocrine neoplasia. This is a narrative review of literature. We revised full-length papers published in English through PubMed research conducted between January 2018 and May 2023 by using the key words “quality of life” and “primary hyperparathyroidism”. We particularly looked at data on self-reported QoL (through questionnaires). We excluded from the search the studies focused on non-PTH related hypercalcemia, secondary, and/or renal/tertiary hyperparathyroidism, and vitamin D supplementation. Overall, we identified 76 papers and selected for the final analysis 16 original studies on QoL and PHP (a total of 1327 subjects diagnosed with syndromic and non-syndromic PHP). The studies with the largest number of individuals were of 92, 104, 110, 134, 159, as well as 191. A few cohorts (n = 5) were of small size (between 20 and 40 patients in each of them). Concerning the study design, except for 2 papers, all the mentioned studies provided longitudinal information, particularly the timeframe from baseline (before PTx) and after surgery. The post-operatory follow-up was of 3–6 months, but mostly between 1 and 3 years (maximum a decade of surveillance). The age of the patients varies between medians of 56, 62, 64, and 68 years. Most frequent questionnaires were SF-36, PHPQoL, and PAS. Despite not being unanimously similar, an overall reduced score of QoL in patients with PHP versus controls was registered, as well as general improvement following PTx. Variations of QoL results might have a multifactorial background from different comorbidities, studied populations, technical aspects of collecting the data, etc. QoL scores in PHP represents a complex heterogeneous picture, from their correlation with clinical features and lab assays (e.g., the level of serum calcium), the associated comorbidities (such as multiple endocrine neoplasia syndromes), up to the assessment of the QoL improvement after parathyroidectomy (PTx). While current studies do not unanimously agree on each QoL domain, the assessment of QoL might represent a supplementary argument to consider when deciding for PTx, especially in asymptomatic cases and in patients who do not fit into well-known categories of surgery candidates, according to current guidelines, thus assessing QoL in PHP is part of a current research gap. QoL evaluation in PHP remains an open issue, towards which awareness should be cultivated by both endocrinologists and surgeons. The introduction of a routine evaluation of the QoL scores in patients, as well as the selection of the most appropriate questionnaire(s), represents an open chapter thus awareness in mandatory.

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“…Well-differentiated cancer of the thyroid gland is one of the most common types of endocrine neoplasias, representing the ninth most frequent malignancy worldwide [1]. During the last decades, its incidence has increased approximately by 300%, affecting a wide spectrum of patients, including adolescents and young adults, while the female-to-male ratio is estimated to be 1:2 [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…In most cases, thyroid carcinoma is diagnosed incidentally (most commonly after surgery for goiter or multinodular goiter), and symptoms such as dysphagia, neck pain, and hoarseness may appear only in advanced stages. The diagnosis is based on clinical examination, thyroid hormonal blood testing, imaging, and the results of a fine needle aspiration (FNA) biopsy [1]. Depending on the histological type and stage of the disease, management options include surgical removal of the thyroid gland, either combined with neck dissection or not, and radioactive iodine.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients With Well-Differentiated Thyroid Carcinoma After Total Thyroidectomy in Greece

Agglopoulou,

Gkrinia,

Bizaki-Vallaskangas

et al. 2024

Cureus

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Introduction: Well-differentiated thyroid cancer is among the most common types of endocrine cancer. Despite its increasing prevalence, the prognosis of thyroid cancer is rather good, with a five-year survival rate ranging between 80% and 90%, depending on the histological type. Not only the post-treatment complications and the side effects of the lifelong medication but also the possibility of a recurrence may have a negative impact on the patient's quality of life (QoL).Objective: The aim of this study is to investigate the impact of total thyroidectomy on the QoL of patients with well-differentiated thyroid carcinoma.Methods: A prospective study was performed in patients who underwent total thyroidectomy due to welldifferentiated thyroid carcinoma in the Otolaryngology-Head and Neck Surgery Department at the University Hospital of Larissa, Greece. The QoL was evaluated based on the "Quality of Life (Thyroid Version)" questionnaire.Results: One hundred patients participated in the study, with a mean age of 51.24±15.33 years. Of these, 63 (63%) were females and 37 (37%) were males. Social concerns, physical well-being, and psychological wellbeing presented a gradual positive alteration during the first 12 months after the surgery, with psychological well-being reporting the most significant progress of 15.3%. However, spiritual well-being appeared to decline over time. The younger patients progressively improved their physical, psychological, and mental well-being; however, the older patients showed an amelioration of their social skills. Female patients reported higher levels of spiritual well-being, whereas males developed better social skills.Conclusions: In the long term, total thyroidectomy can ameliorate patients' physical status, psychological well-being, and social concerns. However, it might have a negative effect on their mental health during the first 12 months postoperatively. In addition, QoL is directly influenced by demographic characteristics such as age and gender.

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The "not so good" thyroid cancer: a scoping review on risk factors associated with anxiety, depression and quality of life

Cited by 8 publications

References 77 publications

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism

Quality of Life in Patients With Well-Differentiated Thyroid Carcinoma After Total Thyroidectomy in Greece

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