The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats

Phan, Nam Nhut; Wang, Chih‐Yang; Lin, Yen Chang

doi:10.1016/j.tox.2014.07.010

Cited by 28 publications

(20 citation statements)

References 66 publications

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“…Hematoxylin and eosin staining method was described previously by Phan et al [ 52 ]. Briefly, the whole heart was removed and washed twice in PBS to remove the blood as much as possible.…”

Section: Methodsmentioning

confidence: 99%

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PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations

Lin

2018

Oncotarget

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The particle matter with diameter less 2.5μm (PM2.5) easier to adsorb toxic substance, and interfere with pulmonary gas exchange. In this study, cardioprotective effects of low molecular weight (LMW) fucoidan in cardiac hypertrophy subjects induced by PM2.5 exposure was conducted by measuring QT interval, Blood pressure, cardiac structure, metabolites and proteins expression in different organs. After PM2.5 exposure, increase in blood pressure, abnormal cardiac function (Prolongation of Action Potential Duration and QT Interval), and structral remodeling (cardiac hypertrophy and fibrosis) were recorded. Fucoidan supplement in consecutive 28 days can reduce the damage to myocardial injury caused by PM2.5. Clearance effect of fucoidan in serum, heart, kidney, lung and liver was found due to organic and inorganic compounds reduced SOS1, CREB, GSK3b, and GRB2 protein level were changed under PM2.5 exposure. Whereas, only CREB level was reduced after fucoidan treatment. Metabolic alteration was also determined that PM2.5 severely damage cardiac tissue and compromise its function. After treatment with fucoidan, the cardiac function was significantly recovered. Our finding demonstrated that LMW could enhance the cardiac status of mice with PM2.5 exposures by rescued QT interval prolongation, action potential and cardiac hypertrophy, and cardiac fibrosis decline.

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“…Hematoxylin and eosin staining method was described previously by Phan et al [ 52 ]. Briefly, the whole heart was removed and washed twice in PBS to remove the blood as much as possible.…”

Section: Methodsmentioning

confidence: 99%

“…Masson trichrome staining was done as our previous publication [ 52 ]. Masson trichrome staining was done as our previous publication [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

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PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations

Lin

2018

Oncotarget

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“…In a study on arsenic-induced cardiac hypertrophy in rats, bioinformatics analyses implicated cTnI in signaling pathways associated with cardiac remodeling [ 137 ]. Specifically, the pathway analysis revealed potential interactions between cTnI and known transcription factors that mediate hypertrophy [ 137 ]. These findings suggest the possibility of a signal-dependent role for nuclear cTnI in cardiac hypertrophy.…”

Section: Troponin: Multitasking In the Muscle Cellmentioning

confidence: 99%

“…Another study uncovered a novel role for cTnI, where it was implicated in arsenic-induced hypertrophic signaling and interactions with several important transcription factors [ 137 ]. Furthermore, nuclear cTnI was found in the nucleus of MSCs during commitment to the cardiac lineage [ 138 ].…”

Section: Troponin: Multitasking In the Muscle Cellmentioning

confidence: 99%

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

2017

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Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in regulating striated muscle contraction. However, mounting evidence points to novel cellular functions of troponin, with profound implications in cancer, cardiomyopathy pathogenesis and skeletal muscle aging. Here, we highlight the non-canonical roles and aberrant expression patterns of troponin beyond the sarcomeric milieu. Utilizing bioinformatics tools and online databases, we also provide pathway, subcellular localization, and protein-protein/DNA interaction analyses that support a role for troponin in multiple subcellular compartments. This emerging knowledge challenges the conventional view of troponin as a sarcomere-specific protein exclusively involved in muscle contraction and may transform the way we think about sarcomeric proteins, particularly in the context of human disease and aging.

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Assessment of Joint Toxicity of Arsenate and Lead by Multiple Endpoints in Chlamydomonas reinhardtii

Sun,

Jiang,

et al. 2023

Bull Environ Contam Toxicol

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The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats

Cited by 28 publications

References 66 publications

PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations

PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

Assessment of Joint Toxicity of Arsenate and Lead by Multiple Endpoints in Chlamydomonas reinhardtii

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