2016
DOI: 10.1016/j.anai.2016.02.006
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The NPC2 protein

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Cited by 18 publications
(10 citation statements)
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“…We confirmed the relation between the severity of AD and the sensitization to lipocalins and uteroglobins; the association was also confirmed with the onset of AD as well with the allergic rhinitis, but not with bronchial asthma. The homology between different dog and cat allergens such as albumins and lipocalins explains the cross-sensitization between them and allergens from other mammals and the presence of simultaneous sensitization to dogs, cats, and other mammals regardless of whether there is or is not direct exposure to all of them [ 36 , 37 , 38 ]. Some of these antigens cause clinically relevant cross-reactivity between different animals.…”
Section: Discussionmentioning
confidence: 99%
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“…We confirmed the relation between the severity of AD and the sensitization to lipocalins and uteroglobins; the association was also confirmed with the onset of AD as well with the allergic rhinitis, but not with bronchial asthma. The homology between different dog and cat allergens such as albumins and lipocalins explains the cross-sensitization between them and allergens from other mammals and the presence of simultaneous sensitization to dogs, cats, and other mammals regardless of whether there is or is not direct exposure to all of them [ 36 , 37 , 38 ]. Some of these antigens cause clinically relevant cross-reactivity between different animals.…”
Section: Discussionmentioning
confidence: 99%
“…Can f 5 shows a certain homology with prostate-specific antigen, which is also in the kallikrein family. It has been speculated that prior sensitization to Can f 5 from dogs could be associated with a greater propensity for developing allergic reactions to human seminal fluid [ 36 , 37 , 38 ]. Finally, Can f 7, an NPC2-like protein that is homologous with the NPC2 components of house dust mites, has been identified in dogs [ 36 , 37 , 38 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In Niemann-Pick type C disease, disruption of cholesterol esterification leads to the accumulation of free cholesterol and bis-monoacyl-glycerophosphate that further leads to accumulation of low-density lipoprotein-derived cholesterol in lysosomes which presents as infantile hepatosplenomegaly, while neurologic symptoms appear at 2 to 4 years old. 50 The exact role of Can f 7 in dogs remains unclear. Recombinant Can f 7 has been found to bind IgE in 14%–17% (recombinant from yeast and bacteria respectively) of dog sensitized individuals.…”
Section: Introductionmentioning
confidence: 99%
“…Recombinant Can f 7 has been found to bind IgE in 14%–17% (recombinant from yeast and bacteria respectively) of dog sensitized individuals. 50 …”
Section: Introductionmentioning
confidence: 99%