The Nuclear-Ribosomal System during Neuronal Differentiation and Development

Radouco-Thomas, C; Nosal, G; Radouco-Thomas, Simone

doi:10.1007/978-1-4684-7236-3_22

Cited by 17 publications

(7 citation statements)

References 27 publications

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“…Although the term "coiled body" was originally introduced by Monneron and Bernhard (1969), it has been claimed that such a structure is the equivalent of the "accessory body" of Cajal(l903,1910) at the electron microscopic level (Hardin et al, 1969). The existence of similar bodies in neurons has been reported in several areas of the nervous system such as the cerebellar cortex (Herndon, 1963;Radouco-Thomas et al, 1971), trigeminal (Hardin et al, 1969) and sympathetic ganglia (Grillo, 1970), anterior hypothalamus (Le Beux, 1971), cerebral cortex (Buschmann, 1975), and facial nucleus (Kinderman and La Velle, 1976); furthermore, they have also been observed in rat spinal ganglion cells "in vivo" (Hiraoka and Van Breeman, 1963) and "in vitro" (Masurovsky et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Hervás

Villegas²,

Crespo³

et al. 1980

Am. J. Anat.

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In electron microscopic studies of the supraoptic nuclei of the rat hypothalamus, structures identified as "coiled bodies" were found in magnocellular neurons. Although they could be seen elsewhere in mature neurosecretory cells, coiled bodies were commonly encountered in developing neurons during the postnatal period in both sexes. They appeared as distinctive nuclear inclusions consisting of round-to-oval networks of short electron-dense strands embedded in a less dense, fibrillar matrix, and lacking a limiting membrane. In fine structure and stain-affinity, they bore a resemblance to the fibrillar component of the nucleolus. Coiled bodies were located either in close association with the nucleolus or free within the nucleoplasm, showing no specific relationships with the perinucleolar chromatin or with the nuclear envelope. Their origin and functional meaning is discussed in the light of recent ultrastructural and biochemical data on cellular differentiation and nucleolar behavior.

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Section: Discussionmentioning

confidence: 99%

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Hervás

Villegas²,

Crespo³

et al. 1980

Am. J. Anat.

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“…The eightfold symmetry of such radiating threads has also been demonstrated (DanieIs et al, 1969;; compare also the "cartwheel" of Howard and Moore, 1970). It is suggested in some images that the material of the annular granules is in extensive continuity with the projecting tips, thus constituting one whole "cuff" around the pore wall (Andre and RouilIer, 1956;Watson, 1959;Stevens and Swift, 1966;Stevens and Andre, 1969;Abelson and Smith, 1970;; compare also the model drawings of Gall, 1964;Franke, 1966a;Vivier, 1967;Franke and Scheer, 1970a;Radouco-Thomas et al, 1971;Wunderlich and Speth, 1972). However, there is clear demonstration in other nuclei that this is at least not the regular case: here the annular and the internal granules are separated by an electron-transparent gap (e.g., Figs.…”

Section: Structures and Functions Of The Nuclear Envelopementioning

confidence: 96%

Structures and Functions of the Nuclear Envelope

Franke¹,

Scheer²

1974

The Cell Nucleus

153

150

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“…The extreme radiosensitivity of the DNA in early neuroblasts (see [16,27]) provides evidence that origin and transfer of tigroid maturation damage is mediated by DNA defects. Biogenesis of ribosomal RNA results from transcription in the nucleolar organizer (chromocenter), where the r-DNA acts as matrix for the ribosomal RNA [31,39]. Thus, transferred DNA defects including disturbed gene activation appear most likely to cause the ribosomal deficit.…”

Section: Extended Tigroid Maturation Disturbancesmentioning

confidence: 98%

The formation of tigroid substance during postnatal maturation of the brain of mice after pre- and perinatal X-irradiation

Konermann

Schwald

1980

Radiat Environ Biophys

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Using Nissl stained slices of postnatal brain, tigroid formation in neurons of the cortex, thalamus, cerebellum, hippocampus, gyrus dentatus and nucleus mot. trigemini was examined in X-irradiated mice. Following exposure on days 13, 16, 18.5 or 22 post conception with doses ranging from 0.5 Gy to 3.0 Gy tigroid formation was studied by means of a selective microphotometrical measurement technique. After irradiation, a fluctuating diminution in the tigroid density was observed in relation to the controls. It was dependent both on the dose and on the stage of development during exposure. In several brain regions fluctuating tigroid responses, being most pronounced during the "critical periods" of postnatal brain maturation, resulted in a longterm compensation of a deficit in the tigroid density after irradiation with 0.05 Gy. After the higher doses the density diminution was either not compensated or was progressive. The late tigroid responses decrease from irradiation on day 13 p.c. to irradiation day 22 p.c. Hence, this type of late maturation impairment was either extended through several cell generations or it was induced to a lesser degree in the early postmitotic neurons. Changes in the total RNA-content of the brain are concomitant with the range of the tigroid responses during the second and the beginning of the third week after birth. The tigroid reactions were interpreted as a chain of interdependent processes of retardation and stabilization. Accordingly, to obtain a better understanding of long-term maturation defects, a comprehensive evaluation of the whole chain of events will be required.

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The Nuclear-Ribosomal System during Neuronal Differentiation and Development

Cited by 17 publications

References 27 publications

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Structures and Functions of the Nuclear Envelope

The formation of tigroid substance during postnatal maturation of the brain of mice after pre- and perinatal X-irradiation

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