2005
DOI: 10.1101/gad.333205
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The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis

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Cited by 202 publications
(206 citation statements)
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“…The finding that perturbation of nucleolar activity by genetic ablation of ribosome biogenesis initiates neurodegeneration in adult mice by activation of an endogenous response leading to p53 activation (24) is one example of an emerging series of findings that support the idea that the nucleolus acts as a sensor of cellular stress (1,3,(25)(26)(27). The nucleolar protein NS, normally associated with the proliferative status of stem and cancer cells, is reinduced after pathological challenge within the adult heart and is potentially associated with cardioprotective pathways (16).…”
Section: Discussionmentioning
confidence: 95%
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“…The finding that perturbation of nucleolar activity by genetic ablation of ribosome biogenesis initiates neurodegeneration in adult mice by activation of an endogenous response leading to p53 activation (24) is one example of an emerging series of findings that support the idea that the nucleolus acts as a sensor of cellular stress (1,3,(25)(26)(27). The nucleolar protein NS, normally associated with the proliferative status of stem and cancer cells, is reinduced after pathological challenge within the adult heart and is potentially associated with cardioprotective pathways (16).…”
Section: Discussionmentioning
confidence: 95%
“…Nucleoli serve as sensors of stress in noncardiac cells (1,4,24,26), but the involvement and dynamic regulation of nucleoli in cardiomyocytes needs to be established. Nucleolar disruption has been studied in nonmyocytes thorough use of a selective inhibitor of polymerase I transcription known as actinomycin D (ActD; ref.…”
Section: Resultsmentioning
confidence: 99%
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“…The HSV-1 ICP27, ICP0, γ 1 34.5, and U S 11 proteins were reported to possess nucleolar targeting sequences (Cheng et al, 2002;MacLean et al, 1987;Mears et al, 1995;Morency et al, 2005) but the implications of these are unknown. Emerging evidence now argues that nucleoli act as a cellular stress sensor which functions to regulate p53 and cell cycle arrest (Mayer et al, 2005;Rubbi and Milner, 2003). The fate of p53 during HSV infection is unclear as it may be targeted for degradation by ICP0 ubiquitination but it might also be stabilized in certain cell lines (Boutell and Everett, 2003;Boutell and Everett, 2004).…”
Section: Vp22 Targets Nucleolinmentioning
confidence: 99%
“…The rate of rRNA transcription and elongation can be modulated by several factors, including growth factors, 1 cell cycle, 2 and cellular stress. 3 RNA polymerase I (Pol I) is the polymerase dedicated to transcribing the 47S pre-rRNA transcript. This transcript is subsequently processed into 5.8S, 18S…”
mentioning
confidence: 99%