The nucleosome binding protein 1 promotes the growth of gastric cancer cells

Liu, Lantao; Lang, Zhifang; Wang, Pengyu; Wang, Hongwei; Cao, Yanli; Meng, Xiangjun; Hu, Jing; Feng, Yukuan

doi:10.7150/jca.29292

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…At present, little is known about their exact functions in GC. Only HMGN5 has been reported to play an oncogenic role in GC, whereby it promotes GC cell growth (87). HMGN5 was highly expressed in GC cell lines, contrary to the predictions using TCGA cohort.…”

Section: Discussionmentioning

confidence: 67%

Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer

Huang

Yuan

et al. 2022

Front. Oncol.

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BackgroundIn the past decade, considerable research efforts on gastric cancer (GC) have been expended, however, little advancement has been made owing to the lack of effective biomarkers and treatment options. Herein, we aimed to examine the levels of expression, mutations, and clinical relevance of HMGs in GC to provide sufficient scientific evidence for clinical decision-making and risk management.MethodsGC samples were obtained from The Cancer Genome Atlas (TCGA). University of California Santa Cruz (UCSC) XENA, Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier Plotter, cBioPortal, GeneMANIA, STRING, LinkedOmics, and DAVID databases were employed. The “ggplot2” package in the R software (×64 3.6.3) was used to thoroughly analyze the effects of HMGs. qRT-PCR was performed to assess HMG levels in GC cell lines.ResultsA total of 375 GC tissues and 32 paraneoplastic tissues were analyzed. The levels of HMGA1, HMGA2, HMGB1, HMGB2, HMGB3, HMGN1, HMGN2, and HMGN4 expression were increased in GC tissues relative to normal gastric tissues. HMGA1, HMGA2, HMGB1, HMGB2, and HMGB3 were highly expressed in GC cell lines. The OS was significantly different in the group showing low expressions of HMGA1, HMGA2, HMGB1, HMGB2, HMGB3, HMGN2, HMGN3, and HMGN5. There was a significant difference in RFS between the groups with low HMGA2, HMGB3, and high HMGN2 expression. The levels of HMGA2, HMGB3, and HMGN1 had a higher accuracy for prediction to distinguish GC from normal tissues (AUC value > 0.9). HMGs were tightly associated with immune infiltration and tumor immune escape and antitumor immunity most likely participates in HMG-mediated oncogenesis in GC. GO and KEGG enrichment analyses showed that HMGs played a vital role in the cell cycle pathway.ConclusionsOur results strongly suggest a vital role of HMGs in GC. HMGA2 and HMGB3 could be potential markers for prognostic prediction and treatment targets for GC by interrupting the cell cycle pathway. Our findings might provide renewed perspectives for the selection of prognostic biomarkers among HMGs in GC and may contribute to the determination of the optimal strategy for the treatment of these patients.

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Section: Discussionmentioning

confidence: 67%

Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer

Huang

Yuan

et al. 2022

Front. Oncol.

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“…As reported by King and Francomano in 2001 (30), the HMGN5 gene is upregulated and confers oncogenic effects in various tumors, such as bladder cancer (31), renal cancer (32), colorectal cancer (33), esophageal squamous cell carcinoma (34) and pancreatic ductal adenocarcinoma (35), etc. HMGN5 appears wildly involved in cancer cell growth, apoptosis, angiogenesis, migration, invasion, and EMT to promote tumorigenesis (36)(37)(38)(39)(40). However, few reports revealed the precise molecular mechanisms of HMGN5 in tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis

Mou

Huang

Wang

et al. 2022

Molecular Cancer Research

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Cancer progression is highly dependent on the ability of cancer cell tumor formation, in which epigenetic modulation plays an essential role. However, the epigenetic factors promoting breast tumor formation are less known. Screened from 3D-sphere tumor formation model, HMGN5 which regulates chromatin structures became the candidate therapeutic target in breast cancer, though its role is obscure. HMGN5 is highly expressed in 3D-spheres of breast cancer cells and clinical tumors, also an unfavorable prognostic marker in patients. Furthermore, HMGN5 controls tumor formation and metastasis of breast cancer cells in vitro and in vivo. Mechanistically, HMGN5 is governed by active STAT3 transcriptionally and further escorts STAT3 to shape the oncogenic chromatin landscape and transcriptional program. More importantly, interference of HMGN5 by nanoparticle-packaged siRNA effectively inhibits tumor growth in breast cancer cell-derived xenograft mice model. Implications: Our findings reveal a novel feed-forward circuit between HMGN5 and STAT3 in promoting breast cancer tumorigenesis and suggest HMGN5 as a novel epigenetic therapeutic target in STAT3-hyperactive breast cancer.

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The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids

Świerczewska

Sterzyńska

Ruciński

et al. 2023

Biomedicine & Pharmacotherapy

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The nucleosome binding protein 1 promotes the growth of gastric cancer cells

Cited by 6 publications

References 20 publications

Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer

Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer

HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis

The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids

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