2020
DOI: 10.1007/s00774-020-01098-x
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The old sheep: a convenient and suitable model for senile osteopenia

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Cited by 6 publications
(14 citation statements)
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“…Aged, osteopenic, female sheep (total of 72 animals; Schwarzkopf-Merino; 6–10 years old; 9.00 ± 0.11 years; mean ± SEM; 45–76 kg body weight) were used for osteodensitometry, histological analyses, and biomechanical testing [ 40 ].…”
Section: Methodsmentioning
confidence: 99%
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“…Aged, osteopenic, female sheep (total of 72 animals; Schwarzkopf-Merino; 6–10 years old; 9.00 ± 0.11 years; mean ± SEM; 45–76 kg body weight) were used for osteodensitometry, histological analyses, and biomechanical testing [ 40 ].…”
Section: Methodsmentioning
confidence: 99%
“…Quantitative static histomorphometry of the lumbar vertebral bodies (L3–L5) was performed according to published procedures [ 40 , 54 , 55 , 56 , 57 , 58 , 59 ]. After cutting the lumbar vertebral bodies into two opposite complementary parts directly at the injection channel, the analyses were carried out using two different types of histological sections ( n = 1 each per animal and vertebral body): (i) decalcified paraffin sections (7 μm thickness stained by hematoxylin-eosin; [ 60 ]) or (ii) plastic-embedded sections stained with trichrome stain according to Masson-Goldner [ 61 ] after fixation in Carnoy’s solution for 12 h at 21 °C, dehydration in ascending alcohol series without demineralization, impregnation with a mixture of alcohol/Technovit 7200VLC = 1:1, followed by infiltration with pure Technovit 7200VLC (Heraeus Kulzer, Hanau, Germany), and embedding into methacrylate-based resin [ 62 ].…”
Section: Methodsmentioning
confidence: 99%
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“…On the other hand, most cortical bone loss occurs at 10 years after menopause due to cortical thinning and increased cortical porosity 60 71 . Bones in most mammals are thought to deteriorate with age, but in animals commonly used in biological research, age-related bone loss is only well documented in crab-eating monkeys 64 , sheep (6 ~ 10 years old) 72 , rats and mice [73][74][75][76][77] .…”
Section: Primary Osteoporosis Model (1) Postmenopausal Osteoporosis Model (Pmop)mentioning
confidence: 99%