The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Abstract

Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment

“…As the outer periphery of functional drug-loaded silica NCs resembles cellular membranes, these are recognized as self-assembled, owing to which, their toxic side effects are minimized. Serious concerns of this sort have been reported for atherosclerosis treatment [ 212 ]. Rigorous characterization and a vigilant precursor–template stoichiometry selection via in silico computational tools could minimize these limitations.…”

Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview

“…A multi-functional bioresorable electronic stent was successfully generated to promote flow sensing, wireless power data transmission, inflammation suppression, and localized drug delivery [177]. Mesoporous silica AuNPs were also integrated for their enhanced efficacy in CVDs in several in vitro, ex vivo, and in vivo settings [180].…”

Biopolímeros: Aplicaciones de andamios en medicina regenerativa

“…Las bioimpresoras capaces de generar un andamio en tres dimensiones unificando todas sus propiedades bioactivas capaces de funcionalizar tejidos de manera acelerada permitiendo el desarrollo celular (Sha, et al, 2021). Uno de los campos más estudiados es la regeneración ósea por la cantidad de defectos óseos que siguen apareciendo debido a enfermedades catastróficas; el injerto óseo es uno de los más utilizados por su biocompatibilidad para lesiones de reparación o fracturas.…”