2022
DOI: 10.1371/journal.pone.0277427
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The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls

Abstract: Fibromyalgia (FM) patients have dysfunctional endogenous pain modulation, where opioid and serotonergic signaling is implicated. The aim of this study was to investigate whether genetic variants in the genes coding for major structures in the opioid and serotonergic systems can affect pain modulation in FM patients and healthy controls (HC). Conditioned pain modulation (CPM), evaluating the effects of ischemic pain on pressure pain sensitivity, was performed in 82 FM patients and 43 HC. All subjects were genot… Show more

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Cited by 5 publications
(1 citation statement)
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“…So far, genetic studies that have examined the 5-HT 1A receptor and 5-HT 2A receptor gene polymorphisms, as well as studies measuring 5-HT blood levels, have produced mixed results [31][32][33]. In the case of the SERT, two genetic studies (one PET study and one study on gene expression) have also produced mixed results [34,35].…”
Section: Introductionmentioning
confidence: 99%
“…So far, genetic studies that have examined the 5-HT 1A receptor and 5-HT 2A receptor gene polymorphisms, as well as studies measuring 5-HT blood levels, have produced mixed results [31][32][33]. In the case of the SERT, two genetic studies (one PET study and one study on gene expression) have also produced mixed results [34,35].…”
Section: Introductionmentioning
confidence: 99%