The Optic Nerve in Glaucoma

Marjanović, Ivan

doi:10.5772/19811

Cited by 5 publications

(6 citation statements)

References 62 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been various attempts to find a useful CDR cutoff value to classify ODs as the glaucomatous or normal. The classification cutoff based on the CDR formula is suggested by Marjanovic [33], as follows. To detect the signs of glaucoma, the cutoff difference is set to be between 0.3 and 0.5.…”

Section: Glaucoma Classificationmentioning

confidence: 99%

Glaucoma Detection in Mobile Phone Retinal Images Based on ADI-GVF Segmentation with EM initialization

et al. 2021

View full text Add to dashboard Cite

The advanced development of mobile phone and lens technology has made retinal imaging more convenient than ever before. In the digital health era, mobile phone fundus photography has evolved into a low-cost alternative to the standard ophthalmoscope. Existing image processing algorithms have a problem with handling the narrow field of view and poor quality of retinal images from a mobile phone. This paper enhances the accuracy of our previously proposed scheme, ADI-GVF snakes, to improve the segmentation of the optic disk (OD) and the optic cup (OC) for glaucoma pre-screening [1] from retinal images obtained from a mobile phone. This work integrated a better OD localization method, namely, the exclusion method (EM) with ADI-GVF segmentation for the OD and the OC. The improved algorithm can segment the regions of the OD and OC more accurately, resulting in a more precise value of the cup-to-disk area ratio (CDAR). The proposed method yields as high as 93.33% for true positive rate (TPR) and 93.87% for true negative rate (TNR) and as low as 6.12% and 6.66% for false omission rate (FOR), and false discovery rate (FDR). It also improves TPR, TNR, FOR, and FDR of the previous scheme [1] by 4.45%, 4.08%, 4.08%, and 4.44% respectively.

show abstract

Section: Glaucoma Classificationmentioning

confidence: 99%

Glaucoma Detection in Mobile Phone Retinal Images Based on ADI-GVF Segmentation with EM initialization

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The change of the optic disc, known as “cupping of the optic disc” is its vertical elongation and is accompanied by the loss of the neuroretinal rim, which can be visualized on the superior and inferior poles of the optic disc ( Figure 1 c) [ 3 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Drug Delivery Systems Fighting Glaucoma: Formulation Obstacles and Solutions

et al. 2020

View full text Add to dashboard Cite

Glaucoma is considered to be one of the biggest health problems in the world. It is the main cause of preventable blindness due to its asymptomatic nature in the early stages on the one hand and patients’ non-adherence on the other. There are several approaches in glaucoma treatment, whereby this has to be individually designed for each patient. The first-line treatment is medication therapy. However, taking into account numerous disadvantages of conventional ophthalmic dosage forms, intensive work has been carried out on the development of novel drug delivery systems for glaucoma. This review aims to provide an overview of formulation solutions and strategies in the development of in situ gel systems, nanosystems, ocular inserts, contact lenses, collagen corneal shields, ocular implants, microneedles, and iontophoretic devices. The results of studies confirming the effectiveness of the aforementioned drug delivery systems were also briefly presented.

show abstract

“…ONH is defined as region from where RGCs exit eye, through LC via scleral canal 4. There are no histologically distinct layers of ONH, studies describe it to be consisting of superficial retinal nerve fiber layer (RNFL), prelaminar tissue (PT), laminar tissue composed of LC itself and retrolaminar layers 5-9…”

Section: Introductionmentioning

confidence: 99%

“…Area of optic cup and disc are interrelated, so small discs have small cup sizes and vice versa 5. Average CDR in small disc arises suspicion of GON4.…”

Section: Introductionmentioning

confidence: 99%

“…CDR value of 0.4-0.8 indicates physiological cupping or early to moderate glaucoma, CDR of ≥0.8 directs towards GON, unless proven otherwise 35. An asymmetrical CDR of 0.2 between eyes of an individual points early stage of glaucoma 5. Vertical elongation of optic cup results due to loss of neuroretinal rim (NRR) at superoinferior optic cup poles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Unfolding the enigma of lamina cribrosa morphometry and its association with glaucoma

Saba

Usmani

Islam³

et al. 2019

Pak J Med Sci

View full text Add to dashboard Cite

Primary open angle glaucoma (POAG) is worldwide prevalent ailment, affecting millions, and leading irreversible cause of blindness. The treatment strategies revolve around one modifiable factor, elevated intraocular pressure (IOP), despite POAG presenting with normal IOP. Emphasis is put forth in recent past detecting structural elements of glaucoma; lamina cribrosa (LC) is found to be a promising prospect. Morphological alterations of LC are implicated as early sign before onset of glaucomatous optic neuropathy (GON). In this review, the authors explored scientific works from 1976 till 2018 through Google, Google Scholar, PubMed, HEC Digital Library, Springerlink, and PakMedinet in four months’ time, extracted structural features of LC, its measurable attributes, fresh innovations employed for in-vivo visualization and clinical signs aiding in establishing diagnosis of glaucoma which will assist as a prophylactic measure against GON. No such work has ever been done in South-East Asia including our country. So LC opens a new horizon for research in Pakistan.

show abstract

The Optic Nerve in Glaucoma

Cited by 5 publications

References 62 publications

Glaucoma Detection in Mobile Phone Retinal Images Based on ADI-GVF Segmentation with EM initialization

Glaucoma Detection in Mobile Phone Retinal Images Based on ADI-GVF Segmentation with EM initialization

Novel Drug Delivery Systems Fighting Glaucoma: Formulation Obstacles and Solutions

Unfolding the enigma of lamina cribrosa morphometry and its association with glaucoma

Contact Info

Product

Resources

About