The Optic Radiation and the Cerebellar Peduncles in Adolescents with First‐Admission Schizophrenia —A Diffusion Tensor Imaging Study

Henze, Romy; Brunner, Romuald; Thiemann, Ulf; Parzer, Peter; Klein, Jan; Resch, Franz; Stieltjes, Bram

doi:10.1111/j.1552-6569.2011.00668.x

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…39 However, the middle cerebellar peduncle (MCP) which carries input fibers from the contralateral cerebral cortex to the cerebellar cortex via the pons was not significantly lowered in adolescents with first-admission or chronic schizophrenia patients. 40,41 We also documented that the MCP was not disordered in our patients (for further details see Table S2 in the online supplement).…”

Section: Discussionsupporting

confidence: 67%

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis

Lee

Suh

et al. 2019

JNP

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Evidence suggests that the cortico-striatalthalamo-cortical circuitry plays an important role in schizophrenia pathophysiology. Cerebellar contribution from deep cerebellar nuclei to the circuitry has not yet been examined. The authors investigated resting-state functional connectivity (RSFC) of cerebellar output nuclei with striatal-thalamiccortical regions in relation to white-matter integrity and regional gray-matter volumes in first-episode psychosis (FEP).Methods: Forty FEP patients and 40 age-and gendermatched healthy control subjects (HCs) participated. RSFC between cerebellar nuclei and striatal-thalamic-cortical regions was examined. Diffusion tensor imaging and volumetric scans were examined for possible structural constraints on RSFC. The authors also examined relationships between neuroimaging variables and cognitive and clinical measures.Results: FEP patients, compared with HCs, exhibited decreased RSFC between the left fastigial nucleus and right putamen, which was associated with poor letter fluency performance and lower global assessment of functioning scores. By contrast, patients showed widespread increased accumbens network connectivity in the left nucleus. The authors further observed both hypo-and hyper-RSFC between the cerebellar nuclei and fronto-parietal areas in patients, independent of striatal activity. Finally, the authors found impaired integrity of the left superior cerebellar peduncle and decreased bilateral putamen volume in patients, whereas structural-functional relationships found in HCs were absent in patients. Conclusions:This study provides evidence of disordered RSFC of cerebellar output nuclei to the striatum and neocortex at the early stage of schizophrenia. Furthermore, dysfunctional cerebellar influences on fronto-parietal areas that are independent of striatal dysfunction in patients with FEP were observed. The results suggest that cortico-striatal abnormalities in patients with FEP are produced by abnormal cerebellar influences.

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Section: Discussionsupporting

confidence: 67%

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis

Lee

Suh

et al. 2019

JNP

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“…Contrary to our findings, several studies on the connectivity of thalamo-cortical networks in patients with SZ have reported that patients with SZ show no significant differences in functional or structural connectivity of the occipital cortex with the thalamus compared with HCs [ 64 – 66 ]. Conversely, patients with SZ display significantly decreased FA in optic radiations compared with HCs [ 67 , 68 ]. Optic radiation structure and correlations of structure measures with visual masking performance in patients with SZ were investigated [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Altered white matter connectivity in patients with schizophrenia: An investigation using public neuroimaging data from SchizConnect

et al. 2018

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Several studies have produced extensive evidence on white matter abnormalities in schizophrenia (SZ). However, optimum consistency and reproducibility have not been achieved, and reported low white matter tract integrity in patients with SZ varies between studies. A whole-brain imaging study with a large sample size is needed. This study aimed to investigate white matter integrity in the corpus callosum and connections between regions of interests (ROIs) in the same hemisphere in 122 patients with SZ and 129 healthy controls with public neuroimaging data from SchizConnect. For each diffusion-weighted image (DWI), two-tensor full-brain tractography was performed; DWIs were parcellated by processing and registering T1 images with FreeSurfer and Advanced Normalization Tools. White matter query language was used to extract white matter fiber tracts. We evaluated group differences in means of diffusion measures between the patients and controls, and correlations of diffusion measures with the severity of clinical symptoms and cognitive impairment in the patients using the Positive and Negative Syndrome Scale (PANSS), a letter-number sequencing (LNS) test, vocabulary test, letter fluency test, category fluency test, and trail-making test, part A. To correct for multiple comparisons, a false discovery rate of q < 0.05 was applied. In patients with SZ, we observed significant radial diffusivity (RD) and trace (TR) increases in left thalamo-occipital tracts and the right uncinate fascicle, and a significant RD increase in the right middle longitudinal fascicle (MDLF) and the right superior longitudinal fascicle ii. Correlations were present between TR of left thalamo-occipital tracts, and the letter fluency test and the LNS test, and RD in the right MDLF and PANSS positive subscale score. However, these correlations were not significant after correction for multiple comparisons. These results indicated widespread white matter fiber tract abnormalities in patients with SZ, contributing to SZ pathophysiology.

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“…The affected WM regions seem to be more widespread with a less consistent pattern of differences. Most EOS studies have generally identified less extensive frontal, 67,68,85,92 temporal, 49,86 parietal 69,70 and occipital 49,68,139 WM differences in patients compared to NC but there have also been three studies from the same research group using track-based spatial statistics (TBSS) reporting widespread findings. 55,90,91 WM tracts in EOS also seem to follow different maturational trajectories as inferred by FA compared to adult samples.…”

Section: Ii) Fes/ros Subjectsmentioning

confidence: 99%

White Matter Alterations in Early Stages of Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies

Samartzis

Dima

Fusar‐Poli

et al. 2013

Journal of Neuroimaging

212

138

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Several lines of evidence suggest that the normal integration of cerebral communication may be compromised in schizophrenia, with white matter (WM) abnormalities being integral to these functional deficits. Diffusion tensor imaging (DTI) is a neuroimaging technique which has increasingly been used to study WM through quantitative indices of its structural and orientational characteristics. Identifying the WM differences early in the course of schizophrenia may assist in prevention, early diagnosis and identification of treatment targets. In that respect, the aims of the present study were to (a) systematically review WM integrity in the early stages of schizophrenia as inferred by DTI and (b) specifically examine parameters that may affect WM: age, duration of illness and treatment. In summary, DTI studies in early schizophrenia suggest that structural dysconnectivity may be already present in recent-onset and drug-naïve patients, as well as in individuals clinically at high risk for developing schizophrenia. Although the pattern of WM differences is not totally consistent frontal, fronto-temporal and fronto-limbic connections, with tracts including the superior longitudinal fasciculus, cingulum bundle, uncinate fasciculus and corpus callosum seem to be affected. These differences may depend on the developmental stage of the subjects, the duration of illness and exposure to antipsychotic medication.

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The Optic Radiation and the Cerebellar Peduncles in Adolescents with First‐Admission Schizophrenia —A Diffusion Tensor Imaging Study

Cited by 9 publications

References 26 publications

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis

Altered white matter connectivity in patients with schizophrenia: An investigation using public neuroimaging data from SchizConnect

White Matter Alterations in Early Stages of Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies

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