The Optimization Performance of Fibrous Sodium Alginate Co-Polymer in Direct Methanol/Ethanol Fuel Cells

Hassan, Aya F.; salam, Hanafy M. Abdel; Mohamed, Fatma; Abdel-Gawad, Omayma F.

doi:10.1007/s10924-023-02852-8

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…This presumption can be verified by comparing the relative intensity of the two bands at 794.46 and 715.09 cm −1 . The former is attributed to the 1,4-disubstituted benzene rings in the formation of PANI and it is much stronger than the latter attributed to the 1,2,4-trisubstituted benzene rings in the co-polymer and co-polymer nanocomposite polymerization [ 47 ]. Additionally, since the electro-polymerization of these materials was performed in 0.5 M HCl, Cl − ions are also incorporated into the co-polymer and co-polymer nanocomposite to neutralize the positive charge delocalized over the co-polymer chains [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

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Novel Cytochrome P450-3A4 Enzymatic Nanobiosensor for Lapatinib (a Breast Cancer Drug) Developed on a Poly(anilino-co-4-aminobenzoic Acid-Green-Synthesised Indium Nanoparticle) Platform

January,

Tshobeni,

Ngema

et al. 2023

Biosensors

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Breast cancer (BC) is one of the most common types of cancer disease worldwide and it accounts for thousands of deaths annually. Lapatinib is among the preferred drugs for the treatment of breast cancer. Possible drug toxicity effects of lapatinib can be controlled by real-time determination of the appropriate dose for a patient at the point of care. In this study, a novel highly sensitive polymeric nanobiosensor for lapatinib is presented. A composite of poly(anilino-co-4-aminobenzoic acid) co-polymer {poly(ANI-co-4-ABA)} and coffee extract-based green-synthesized indium nanoparticles (InNPs) was used to develop the sensor platform on a screen-printed carbon electrode (SPCE), i.e., SPCE||poly(ANI-co-4-ABA-InNPs). Cytochrome P450-3A4 (CYP3A4) enzyme and polyethylene glycol (PEG) were incorporated on the modified platform to produce the SPCE||poly(ANI-co-4-ABA-InNPs)|CYP3A4|PEG lapatinib nanobiosensor. Experiments for the determination of the electrochemical response characteristics of the nanobiosensor were performed with cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The nanobiosensor calibration for 0–100 ng/mL lapatinib was linear and gave limit of detection (LOD) values of 13.21 ng/mL lapatinib and 18.6 ng/mL lapatinib in physiological buffer and human serum, respectively. The LOD values are much lower than the peak plasma concentration (Cmax) of lapatinib (2.43 µg/mL), which is attained 4 h after the administration of a daily dose of 1250 mg lapatinib. The electrochemical nanobiosensor also exhibited excellent anti-interference performance and stability.

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Section: Resultsmentioning

confidence: 99%

“…The effect of InNPs on the poly(ANI-co-4-ABA) co-polymer’s oxidation process was also shown. They enhanced the platform’s electroactivity and caused a shift in the anodic peak’s potential from 0.1 V to 0.125 V (A) [ 47 , 91 ]. The main reason for the potential shift was due to the strong adsorption of the InNPs in poly(ANI-co-4-ABA).…”

Section: Resultsmentioning

confidence: 99%