The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis

Zhao, Ya‐Qiong; Feng, Yun‐Zhi; Ye, Qin; Hu, Jing; Feng, Yao; Ouyang, Zeyue; Zhao, Jie; Chen, Yun; Tan, Li; Chen, Ningxin; Dusenge, Marie Aimee; Su, Xiaolin; Guo, Yue

doi:10.3389/fcimb.2022.1047607

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Gut microbes influence both local and systemic immunity (32). The gut microbiome regulates, optimizes, and suppresses host immune responses, and these changes allow infectious diseases to gain the upper hand (33,34). Recent studies have linked an increase in intestinal microbiota Prevotella at mucosal sites to local and systemic inflammation (35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis

Chai,

Liu,

Bai

et al. 2024

Front. Immunol.

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IntroductionThe gut microbiota, T cell subsets, and cytokines participate in tuberculosis (TB) pathogenesis. To date, the mechanisms by which these factors interactively promote TB development at different time points remain largely unclear. In the context of this study, We looked into the microorganisms in the digestive tract, T cell types, and cytokines related to tuberculosis.MethodsAccording to QIIME2, we analyzed 16SrDNA sequencing of the gut microbiome on the Illumina MiSeq. Enzyme-linked immunosorbent assay was used to measure the concentrations of cytokines.ResultsWe showed the presence of 26 identifiable differential microbiomes in the gut and 44 metabolic pathways between healthy controls and the different time points in the development of TB in patients. Five bacterial genera (Bacteroides, Bifidobacterium, Faecalibacterium, Collinsella, and Clostridium) were most closely associated with CD4/CD8, whereas three bacterial taxa (Faecalibacterium, Collinsella, and Clostridium) were most closely associated with CD4. Three bacterial taxa (Faecalibacterium, Ruminococcus, and Dorea) were most closely associated with IL-4. Ruminococcus was most closely associated with IL-2 and IL-10.ConclusionDiverse microorganisms, subsets of T cells, and cytokines, exhibiting varying relative abundances and structural compositions, were observed in both healthy controls and patients throughout distinct phases of tuberculosis. Gaining insight into the function of the gut microbiome, T cell subsets, and cytokines may help modulate therapeutic strategies for TB.

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Section: Discussionmentioning

confidence: 99%

Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis

Chai,

Liu,

Bai

et al. 2024

Front. Immunol.

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“…The SILVA database is a comprehensive web resource for upto-date, quality-controlled databases of aligned rRNA gene sequences from the Bacteria, Archaea and Eukaryota domains (Quast et al, 2013). Several previous studies have also used the SILVA database for oral microbiome analysis (Kennedy et al, 2016;Zhao et al, 2021;Zhao et al, 2022). Furthermore, a recent systematic review of oral peri-implant and periodontal microbiota (Gazil et al, 2022) showed a specific database for oral microbiomes, such as the HOMD (Chen et al, 2010) (https://www.homd.org/).…”

Section: Discussionmentioning

confidence: 99%

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

Yamazaki

Ogura

Minami

et al. 2023

Front. Cell. Infect. Microbiol.

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The relationship between the menstrual cycle and the oral microbiome has not been clarified. The purpose of this study was to assess potential changes in the oral microbiome of healthy young adults using 16S rRNA-based sequencing. Eleven females (aged 23–36 years) with stable menstrual cycles and without any oral problems were recruited. Saliva samples were collected before brushing every morning during the menstrual period. Based on basal body temperatures, menstrual cycles were divided into four phases, namely the menstrual, follicular, early luteal, and late luteal phases. Our results showed that the follicular phase had a significantly higher abundance ratio of the Streptococcus genus than the early and late luteal phases, whereas the abundance ratios of the Prevotella 7 and Prevotella 6 genera were significantly lower in the follicular phase than those in the early and late luteal phases and that in the early luteal phase, respectively. Alpha diversity by the Simpson index was significantly lower in the follicular phase than that in the early luteal phase, and beta diversity showed significant differences among the four phases. Using the relative abundance data and copy numbers of the 16S rRNA genes in the samples, the bacterial amounts in the four phases were compared, and we observed that the follicular phase had significantly lower amounts of the Prevotella 7 and Prevotella 6 genera than the menstrual and early luteal phase, respectively. These results indicate reciprocal changes with the Streptococcus genus and Prevotella genera, particularly in the follicular phase. In the present study, we showed that the oral microbiome profiles are affected by the menstrual cycles of healthy young adult females.

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“…A higher abundance of members of the Prevotellaceae family in the oral cavity predicted SARS-CoV-2 infection in the pregnant cohort included in this study. Members of this bacteria family, such as P. intermedia , are considered the main bacterial species implicated in periodontitis [ 61 ]. Similarly, H. parainfluenzae , an oral commensal associated with beneficial immunomodulatory effects, is decreased in the pregnant women with SARS-CoV-2 included in this study [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

The microbiota of pregnant women with SARS-CoV-2 and their infants

et al. 2023

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Background Infants receive their first bacteria from their birthing parent. This newly acquired microbiome plays a pivotal role in developing a robust immune system, the cornerstone of long-term health. Results We demonstrated that the gut, vaginal, and oral microbial diversity of pregnant women with SARS-CoV-2 infection is reduced, and women with early infections exhibit a different vaginal microbiota composition at the time of delivery compared to their healthy control counterparts. Accordingly, a low relative abundance of two Streptococcus sequence variants (SV) was predictive of infants born to pregnant women with SARS-CoV-2 infection. Conclusions Our data suggest that SARS-CoV-2 infections during pregnancy, particularly early infections, are associated with lasting changes in the microbiome of pregnant women, compromising the initial microbial seed of their infant. Our results highlight the importance of further exploring the impact of SARS-CoV-2 on the infant’s microbiome-dependent immune programming.

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The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis

Cited by 5 publications

References 46 publications

Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis

Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

The microbiota of pregnant women with SARS-CoV-2 and their infants

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