The osteocyte as a therapeutic target in the treatment of osteoporosis

Rochefort, Gaël Y.

doi:10.1177/1759720x14523500

Cited by 33 publications

(35 citation statements)

References 132 publications

(170 reference statements)

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“…Calcium‐sensing receptors present in parathyroid gland, kidney, osteoblasts, and osteocytes influence the release of PTH as well as the calcium homeostasis. Calcilytic drugs act as antagonists to calcium‐sensing receptors . Extracellular calcium activates the calcium‐sensing receptors to regulate the PTH secretion in parathyroid cells.…”

Section: Current Osteoporosis Treatmentmentioning

confidence: 99%

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The underlying pathophysiology and therapeutic approaches for osteoporosis

Awasthi

Mani

Singh

et al. 2018

Medicinal Research Reviews

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With an increase in the ageing population worldwide, the prevalence of osteoporosis increases at an alarming rate in both male and female irrespective of their ethnicity. At present, the currently available therapeutic options are mostly limited to either bone resorptive or bone forming efficacies and both approaches are associated with serious side effects. Despite these options, there is still need for newer therapeutics to treat osteoporosis, which can offer beneficial effects for maintaining balanced dynamics between bone formation and bone resorption, devoid of any side effect. The proper understanding of pathophysiology of the disease is essential for designing or investigating an effective and safe anti-osteoporotic agent. This review represents a discussion around the molecular targets with their implications in disease progression, available therapeutic options, the emerging targets, and the importance of designing an effective anti-osteoporotic agent.

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Section: Current Osteoporosis Treatmentmentioning

confidence: 99%

“…Calcilytic drugs act as antagonists to calcium-sensing receptors. 210 Extracellular calcium activates the calcium-sensing receptors to regulate the PTH secretion in parathyroid cells.…”

Section: Calcilytic Drugmentioning

confidence: 99%

The underlying pathophysiology and therapeutic approaches for osteoporosis

Awasthi

Mani

Singh

et al. 2018

Medicinal Research Reviews

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“…Throughout this review, we have mentioned that osteocytes are the key producers of RANKL, DKK-1 and SOST-1 in adult bone. As the most abundant bone cell, osteocytes may be interesting drug targets, through the use of novel anti-resorptive and anabolic agents and monoclonal antibodies against osteocyte-associated sclerostin (AMG 785 or romozumab) [114]. These agents are currently under clinical trials for osteoporosis; however, a greater need for research in osteocytes in the area of bone metastasis is desired.…”

Section: Resultsmentioning

confidence: 99%

Cancer Cell Colonisation in the Bone Microenvironment

Kan

Vargas

Pape

et al. 2016

IJMS

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Bone metastases are a common complication of epithelial cancers, of which breast, prostate and lung carcinomas are the most common. The establishment of cancer cells to distant sites such as the bone microenvironment requires multiple steps. Tumour cells can acquire properties to allow epithelial-to-mesenchymal transition, extravasation and migration. Within the bone metastatic niche, disseminated tumour cells may enter a dormancy stage or proliferate to adapt and survive, interacting with bone cells such as hematopoietic stem cells, osteoblasts and osteoclasts. Cross-talk with the bone may alter tumour cell properties and, conversely, tumour cells may also acquire characteristics of the surrounding microenvironment, in a process known as osteomimicry. Alternatively, these cells may also express osteomimetic genes that allow cell survival or favour seeding to the bone marrow. The seeding of tumour cells in the bone disrupts bone-forming and bone-resorbing activities, which can lead to macrometastasis in bone. At present, bone macrometastases are incurable with only palliative treatment available. A better understanding of how these processes influence the early onset of bone metastasis may give insight into potential therapies. This review will focus on the early steps of bone colonisation, once disseminated tumour cells enter the bone marrow.

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“…Many of them have an important role in bone. Among them are Insulin -Like Growth Factor-I (IGF-I) and II (IGF-II) -both involved in bone formation and Transforming Growth Beta Factor (TGF-B) -insociated in bone formation and resorption [20,32].…”

Section: N Growth Factormentioning

confidence: 99%

Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis

Puspitadewi¹,

Auerkari²

2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Increasing age, especially in postmenopausal women, shows a decline in anabolic hormones activity and an increase in anti-anabolic hormones activity. This causes bone resorption and may lead to osteoporosis. Osteoporosis is a degenerative disorder marked by decrease in bone mass because of imbalance between bone resorption and formation. Bone strength is determined by morphology, bone structure & geometry, bone remodelling and quality of extracellular matrix. The balance in bone resorption and formation determines bone density and affects one's susceptibility to bone fracture. Bone resorption is affected by bone metabolism process on cellular level, and on edentulous areas is more affected by hormonal, nutritional and metabolism factors. Morrison and Coll have found that there are many polymorphisms in osteoporosis etiopathogenesis, some among them showing a large influence on BMD (Bone mineral density) compared to others, including Estrogen, VDR, COLIA1, PTH, PTHR1,and encoding genes for some cytokines and growth factors.

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The osteocyte as a therapeutic target in the treatment of osteoporosis

Cited by 33 publications

References 132 publications

The underlying pathophysiology and therapeutic approaches for osteoporosis

The underlying pathophysiology and therapeutic approaches for osteoporosis

Cancer Cell Colonisation in the Bone Microenvironment

Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis

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