The Panc 3 Score

Brown, Alphonso; James-Stevenson, Toyia N.; Dyson, Tara; Grunkenmeier, David

doi:10.1097/01.mcg.0000248005.73075.e4

Cited by 62 publications

(18 citation statements)

References 20 publications

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“…They found out that all three factors combined had a posttest likelihood ratio of 99% of developing severe acute pancreatitis. [4]…”

Section: Discussionmentioning

confidence: 99%

“…in 2007 found out that combining parameters such as hematocrit, body mass index (BMI), and pleural effusion led to posttest likelihood of disease to be 99% and hence the term PANC3 score was coined. [4] In our study, PANC3 score, which does not utilize any sophisticated scoring and is economic to the patients, is being evaluated as scoring system for triaging patients according to severity early in the course of disease for better outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of PANC3 score in predicting severity of acute pancreatitis

2017

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Introduction:Acute pancreatitis is inflammatory process of the pancreas associated with local and systemic complications. At present, there are lots of scores (such as Ransons, APACHE II, bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission but these are time consuming or require complex calculation and are costly.Material and Methods:PANC3 Scoring System is one of the better systems because the three criteria used (hematocrit, body mass index, and pleural effusion) are simple, easy to assess, readily available, and economic. In this prospective study, 100 cases were evaluated to see the prospects of PANC3 scoring in predicting the severity of acute pancreatitis as decided by modified Marshals score.Results:The results showed that PANC3 score had a 96.43% specificity, 75% sensitivity, 80% positive predictive value, and 95.29% negative predictive value.Conclusion:Hence, the PANC3 score is a cost-effective, promising score that helps in predicting the severity of acute pancreatitis leading to prompt treatment and early referral to higher center.

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“…They found out that all three factors combined had a posttest likelihood ratio of 99% of developing severe acute pancreatitis. [4]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of PANC3 score in predicting severity of acute pancreatitis

2017

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“…Published cutoff values were used to compare their performance characteristics as discrete variables [9, 17, 18]. The same approach was used to study the association between admission Glasgow scores and organ failure, SIRS development, and local complications.…”

Section: Methodsmentioning

confidence: 99%

“… a Number ( N ) of patients for which all data for score available b Cutoffs based on prior literature reports [9, 17, 18] …”

Section: Figmentioning

confidence: 99%

The Pancreatitis Activity Scoring System predicts clinical outcomes in acute pancreatitis: findings from a prospective cohort study

Buxbaum

Quezada

Chong

et al. 2018

American Journal of Gastroenterology

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OBJECTIVES: The Pancreatitis Activity Scoring System (PASS) has been derived by an international group of experts via a modified Delphi process. Our aim was to perform an external validation study to assess for concordance of the PASS score with high face validity clinical outcomes and determine specific meaningful thresholds to assist in application of this scoring system in a large prospectively ascertained cohort. METHODS: We analyzed data from a prospective cohort study of consecutive patients admitted to the Los Angeles County Hospital between March 2015 and March 2017. Patients were identified using an emergency department paging system and electronic alert system. Comprehensive characterization included substance use history, pancreatitis etiology, biochemical profile, and detailed clinical course. We calculated the PASS score at admission, discharge, and at 12 h increments during the hospitalization. We performed several analyses to assess the relationship between the PASS score and outcomes at various points during hospitalization as well as following discharge. Using multivariable logistic regression analysis, we assessed the relationship between admission PASS score and risk of severe pancreatitis. PASS score performance was compared to established systems used to predict severe pancreatitis. Additional inpatient outcomes assessed included local complications, length of stay, development of systemic inflammatory response syndrome (SIRS), and intensive care unit (ICU) admission. We also assessed whether the PASS score at discharge was associated with early readmission (re-hospitalization for pancreatitis symptoms and complications within 30 days of discharge). RESULTS: A total of 439 patients were enrolled, their mean age was 42 (±15) years, and 53% were male. Admission PASS score >140 was associated with moderately severe and severe pancreatitis (OR 3.5 [95% CI 2.0, 6.3]), ICU admission (OR 4.9 [2.5, 9.4]), local complications (3.0 [1.6, 5.7]), and development of SIRS (OR 2.9 [1.8, 4.5]) as well as prolongation of hospitalization by a mean of 1.5 (1.3–1.7) days. For the prediction of moderately severe/severe pancreatitis, the PASS score (AUC = 0.71) was comparable to the more established Ranson’s (AUC = 0.63), Glasgow (AUC = 0.72), Panc3 (AUC = 0.57), and HAPS (AUC = 0.54) scoring systems. Discharge PASS score >60 was associated with early readmission (OR 5.0 [2.4, 10.7]). CONCLUSIONS: The PASS score is associated with important clinical outcomes in acute pancreatitis. The ability of the score to forecast important clinical events at different points in the disease course suggests that it is a valid measure of activity in patients with acute pancreatitis.

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“…(11) Physical exam should specifically include mental status testing, cardiovascular and fluid status, pulmonary edema, abdominal tenderness, presence of bowel sounds as part of the evaluation. Initial imaging studies to consider include a chest x-ray to detect pulmonary edema and/or pleural effusions which are consistent with vascular leak syndrome(12). Although a computed tomography (CT) scan is useful for diagnosis, identifying pancreatitis risk factors and for evaluating disease complications if is generally not required to make the diagnosis of AP and should be delayed.…”

Section: Initial Evaluation and Management Of Apmentioning

confidence: 99%

Genetics of acute and chronic pancreatitis

Mounzer

Whitcomb²

2013

Current Opinion in Gastroenterology

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Purpose of review Acute pancreatitis (AP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are interrelated and progressive inflammatory disorders of the pancreas with highly variable and complex susceptibility, severity and outcomes. The role of genetics in AP, RAP and progression to CP within a new framework is needed. Recent findings The first genome-wide association study in pancreas has been published with genome-wide significance linked with non-coding variants at the PRSS1-PRSS2 locus on chromosome 7 and the CLDN2 locus on the X chromosome. A new personalized medicine paradigm is considered to facilitate organization of genetic and other susceptibility risk compared to risk of disease progression or resolution and risk of complications. Summary A new framework for organizing multiple, complex data sets is emerging. The role of genetics in the context of other variables, is important in understanding susceptibility to RAP and in the modification of disease severity and progression to CP. Questions of when to order testing, what to order and how to use the data in real time remains an area for future research and development.

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The Panc 3 Score

Abstract: The Panc 3 score is easy to use and accurate for the prediction of SAP. The serum HCT was the strongest predictor of SAP. The combination of the Panc 3 variables was highly predictive of SAP.

Cited by 62 publications

References 20 publications

Assessment of PANC3 score in predicting severity of acute pancreatitis

Assessment of PANC3 score in predicting severity of acute pancreatitis

The Pancreatitis Activity Scoring System predicts clinical outcomes in acute pancreatitis: findings from a prospective cohort study

Genetics of acute and chronic pancreatitis

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