The Parameters of Liver Functional State as a Risk Factor of Edematous Pancreatitis Development Providing of Genetic Determination of Il-4 Production

Ivashchuk, S. I.; Sydorchuk, Larysa

doi:10.36740/wlek201904126

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These mechanisms may explain why GGT affects the occurrence of AP. ALP, ALT, AST, and TBil are serological indicators currently used in clinical practice to reflect liver injury, and studies have shown that indicators of liver damage correlate with the severity of AP disease [23]. However, there is no evidence that the ALP and AST levels are risk factors for AP, which is consistent with the results of our Mendelian analysis.…”

Section: Plos Onesupporting

confidence: 83%

Assessing the causal link between liver function and acute pancreatitis: A Mendelian randomisation study

Zhang,

Lin,

Guo

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

A correlation has been reported to exist between exposure factors (e.g. liver function) and acute pancreatitis. However, the specific causal relationship remains unclear. This study aimed to infer the causal relationship between liver function and acute pancreatitis using the Mendelian randomisation method. We employed summary data from a genome-wide association study involving individuals of European ancestry from the UK Biobank and FinnGen. Single-nucleotide polymorphisms (SCNPs), closely associated with liver function, served as instrumental variables. We used five regression models for causality assessment: MR-Egger regression, the random-effect inverse variance weighting method (IVW), the weighted median method (WME), the weighted model, and the simple model. We assessed the heterogeneity of the SNPs using Cochran’s Q test. Multi-effect analysis was performed using the intercept term of the MR-Egger method and leave-one-out detection. Odds ratios (ORs) were used to evaluate the causal relationship between liver function and acute pancreatitis risk. A total of 641 SNPs were incorporated as instrumental variables. The MR-IVW method indicated a causal effect of gamma-glutamyltransferase (GGT) on acute pancreatitis (OR = 1.180, 95%CI [confidence interval]: 1.021–1.365, P = 0.025), suggesting that GGT may influence the incidence of acute pancreatitis. Conversely, the results for alkaline phosphatase (ALP) (OR = 0.997, 95%CI: 0.992–1.002, P = 0.197) and aspartate aminotransferase (AST) (OR = 0.939, 95%CI: 0.794–1.111, P = 0.464) did not show a causal effect on acute pancreatitis. Additionally, neither the intercept term nor the zero difference in the MR-Egger regression attained statistical significance (P = 0.257), and there were no observable gene effects. This study suggests that GGT levels are a potential risk factor for acute pancreatitis and may increase the associated risk. In contrast, ALP and AST levels did not affect the risk of acute pancreatitis.

show abstract

Section: Plos Onesupporting

confidence: 83%

Assessing the causal link between liver function and acute pancreatitis: A Mendelian randomisation study

Zhang,

Lin,

Guo

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Досі невідомо, яку конкретну роль генетичні чинники відіграють у розвитку цих захворювань [9,10]. Генетичні чинники визначають активність глутатіонового антиоксидантного захисту, взаємопов'язані зі змінами метаболізму жирів та вуглеводів, а також впливають на транспорт та сигнальні шляхи ключових поживних речовин (цинк, селен, йод тощо) для роботи імунної, ендокринної і нервової систем [11,12].…”

Section: вступunclassified

Analysis of the selenoprotein P (rs7579) gene polymorphism and expression in patients with chronic pancreatitis combined with hypothyroidism

Ratsa,

Fediv,

Sydorchuk

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

Background. The specific role and place of genetic factors in the development of chronic pancreatitis and hypothyroidism, which determine the activity of glutathione antioxidant protection, have not been clarified. They are interconnected with changes in the fat and carbohydrate metabolism, and also affect the transport and signaling pathways of key nutrients for the work of the immune, endocrine and nervous systems. The purpose of the study is to investigate the selenoprotein P (SEPP1) (rs7579) gene polymorphism and expression in patients with chronic pancreatitis combined with hypothyroidism. Materials and methods. Forty-nine patients with chronic pancreatitis and hypothyroidism and 30 practically healthy individuals passed the screening stage. The SEPP1 (rs7579) gene polymorphism was determined by the polymerase chain reaction. Results. The study showed that out of 98 isolated alleles in patients with chronic pancreatitis and hypothyroidism and 60 alleles of the control group, the G allele of the SEPP1 gene (rs7579, 25191G/A) dominated over the A allele: in the examined patients — by 34.7 % (χ2 = 23.59; p < 0.001), in the practically healthy group — by 53.34 % (χ2 = 34.13; p < 0.001). At the same time, the relative frequency of individual genotypes, as well as wild-type and mutant alleles, probably did not differ between the experimental and control groups. The A allele of the SEPP1 gene (rs7579) slightly increases the risk of chronic pancreatitis in the studied population, but non-significantly [risk ratio (RR) = 1.43; RR 95% CI (confidence interval): 0.91–2.26; odds ratio (OR) = 1.65; OR 95% CI: 0.88–3.08; p = 0.115]. Conclusions. In patients with chronic pancreatitis who are residents of Northern Bukovyna, mutation of the SEPP1 gene (rs7579, 25191G/A) in the homozygous state occurs with a frequency of 10.2 %, while it is absent in practically healthy people. In both groups, the G allele dominates over the A allele: in the examined patients — by 34.7 % (χ2 = 23.59; p < 0.001), in controls — by 53.34 % (χ2 = 34.13; p < 0.001). SEPP1 gene polymorphism (rs7579, 25191G/A) does not determine the risk of chronic pancreatitis in the population. However, the A allele increases the risk of hypothyroidism in chronic pancreatitis patients twice [OR = 2.0; OR 95% CI: 1.09–3.66; p = 0.023], with the lowest chances of its appearance in carriers of the G allele [OR = 0.50; OR 95% CI: 0.27–0.91; p = 0.023]. Mapping of the expression quantitative trait loci on both sides of the SEPP1 gene (rs7579) transcription start site evidenced 152 statistically significant cis-variants of rs7579 of the SEPP1 gene (SELENOP) associations with the expression of 20 genes in 35 different organs and tissues and 22 phenotypic traits.

show abstract

“…About 78% patients with AP present with generalized peritonitis and 26% with severe peritonitis. The overall mortality rate significantly decreased (15-25%) over last decades but remains high [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Application of Antibiotics and Probiotics for Prevention of Antibiotic-Associated Disbiosis in Patients With Generalized Peritonitis and Enteral Dysfunction Supports Staff Awareness

et al. 2021

View full text Add to dashboard Cite

The aim: To clarify the efficacy of probiotics use as a preventive measure for post-antibiotic treatment in acute peritonitis and increase staff awareness related to antibiotic and probiotic use. Materials and methods: The study design included determination of the proper antibiotic and probiotic strain combination and clinical application of probiotic strains. The control group consisted of 63 (48.46%) patients who underwent traditional multimodal treatment of peritonitis and the study group of 67 (51.54%) individuals, with inclusion of different antibiotic/probiotic combinations. Results: Prior to antimicrobial therapy 67.7% patients of both groups’ patients had severe dysbiosis, proving dysbiosis as a sign of peritonitis. S. boulardii showed widest resistance spectrum and was used for probiotic therapy in study group. Intestinal dysbiosis grades distribution in control group significantly worsened, while in study group ratio of severe dysbiosis significantly dropped from 58.2% to 38.8% with significant growth of grade II dysbiosis to 61.2%. No visible differences in disease course and clinical picture, duration or complications rate between study and control groups were observed. Conclusions: Most of probiotic strains lack antibacterial resistance that makes meaningless their use during systemic antibiotic therapy of acute peritonitis. It is characterized by harsh changes of intestinal microbiota (severe intestinal dysbiosis). While probiotic strains showed antibiotic tolerance, their use presented no significant clinical efficacy, though high level of positive influence on intestinal dysbiosis was observed.

show abstract

The Parameters of Liver Functional State as a Risk Factor of Edematous Pancreatitis Development Providing of Genetic Determination of Il-4 Production

Cited by 3 publications

References 15 publications

Assessing the causal link between liver function and acute pancreatitis: A Mendelian randomisation study

Assessing the causal link between liver function and acute pancreatitis: A Mendelian randomisation study

Analysis of the selenoprotein P (rs7579) gene polymorphism and expression in patients with chronic pancreatitis combined with hypothyroidism

Application of Antibiotics and Probiotics for Prevention of Antibiotic-Associated Disbiosis in Patients With Generalized Peritonitis and Enteral Dysfunction Supports Staff Awareness

Contact Info

Product

Resources

About