The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation

Huynh, Thao Ngoc; Parker, Roy

doi:10.1016/j.jbc.2023.105139

Cited by 4 publications

(1 citation statement)

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“…The NEXT complex is composed of RBM7, ZCCHC8 and MTR4, in which RBM7 brings NEXT to the snoRNA [ 106 ]. The poly(A)-polymerase PAPD5, a subunit of the human TRAMP complex, places a short poly(A) tail at the 3’-end of snoRNAs that recruit exonucleases including the PARN and TOE1 deadenylases [ 105 , 109 , 131 ]. PARN and TOE1 appear to have overlapping roles in removing short poly(A) tails; however, PARN is localized to the nucleolus and hence is involved in 3’-end trimming of snoRNAs, whereas TOE1 is mainly found in Cajal bodies and involved in trimming of scaRNAs [ 109 , 132 ].…”

Section: Processing Of Premature Snornasmentioning

confidence: 99%

Maturation of small nucleolar RNAs: from production to function

Webster,

Ghalei

2023

RNA Biology

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Small Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs with well-defined roles in ribosomal RNA processing, folding and chemical modification. Besides their classic roles in ribosome biogenesis, snoRNAs are also implicated in several other cellular activities including regulation of splicing, transcription, RNA editing, cellular trafficking, and miRNA-like functions. Mature snoRNAs must undergo a series of processing steps tightly regulated by transiently associating factors and coordinated with other cellular processes including transcription and splicing. In addition to their mature forms, snoRNAs can contribute to gene expression regulation through their derivatives and degradation products. Here, we review the current knowledge on mechanisms of snoRNA maturation, including the different pathways of processing, and the regulatory mechanisms that control snoRNA levels and complex assembly. We also discuss the significance of studying snoRNA maturation, highlight the gaps in the current knowledge and suggest directions for future research in this area.

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