The Past, Present and Future of COVID-19 Associated Mucormycosis: A Rapid Review

Sarfraz, Zouina; Sarfraz, Azza; Jaiswal, Vikash; Poudel, Sujan; Bano, Shehar; Hanif, Muhammad; Shrestha, Prakriti Singh; Sarfraz, Muzna; Michel, George; Chérrez-Ojeda, Iván

doi:10.1177/21501319221099476

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…2 Cytokine storm -fuelling deaths in COVID-19 patients CS refers to the over releasing of cytokines into the blood quickly due to infection and other stimulants. Generally, understanding its pathophysiology is complicated, and the lack of regulatory control over pro-inflammatory cytokine production in local and systemic factors is ambiguous (18,19). Some of the infected individuals witnessed considerable deterioration through the coronavirus disease (COVID- 19), linked with cytokine dysregulation and overproduction (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Generally, understanding its pathophysiology is complicated, and the lack of regulatory control over pro-inflammatory cytokine production in local and systemic factors is ambiguous (18,19). Some of the infected individuals witnessed considerable deterioration through the coronavirus disease (COVID- 19), linked with cytokine dysregulation and overproduction (Figure 1). In response to SARS-CoV-2 infection, macrophages and dendritic cells initiate an early immunological response characterized by lymphocytosis and the production of cytokines.…”

Section: Introductionmentioning

confidence: 99%

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Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics

et al. 2023

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The newly emerged coronavirus (SARS-CoV-2) is virulent, contagious, and has rapidly gained many mutations, which makes it highly infectious and swiftly transmissible around the world. SARS-CoV-2 infects people of all ages and targets all body organs and their cellular compartments, starting from the respiratory system, where it shows many deleterious effects, to other tissues and organs. Systemic infection can lead to severe cases that require intensive intervention. Multiple approaches were elaborated, approved, and successfully used in the intervention of the SARS-CoV-2 infection. These approaches range from the utilization of single and/or mixed medications to specialized supportive devices. For critically ill COVID-19 patients with acute respiratory distress syndrome, both extracorporeal membrane oxygenation (ECMO) and hemadsorption are utilized in combination or individually to support and release the etiological factors responsible for the “cytokine storm” underlying this condition. The current report discusses hemadsorption devices that can be used as part of supportive treatment for the COVID-19-associated cytokine storm.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics

et al. 2023

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“… 5 6 7 8 In India, between May 5 and July 2021, 41,512 cases and 3,554 deaths due to mucormycosis were reported in COVID-19-infected patients or COVID-19-recovered patients. 9 In our institute between 30th April 2021 and 4th January 2022, 436 cases of COVID-19-associated mucormycosis were admitted. Out of these 436 cases, 99 patients succumbed to the disease.…”

Section: Introductionmentioning

confidence: 99%

Restoring Quality of Life: Assessing the Impact of Free Flap Reconstruction in Coronavirus Disease 2019-Associated Rhino-Orbital Mucormycosis Patients

Rao,

Agrawal,

Kapoor

et al. 2023

Indian J Plast Surg

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Background In India, between May 5 and July 2021, 41,512 cases and 3,554 deaths due to mucormycosis were reported in coronavirus disease 2019 (COVID-19)-infected patients or COVID-19-recovered patients. COVID-19-associated rhino-orbital mucormycosis (CAROM) has been associated with adverse effects that can affect oral health, vision, and physical as well as emotional functioning. After the radical debridement of CAROM and antifungal therapy, reconstructive surgery should be employed to restore function and aesthetics; however, limited clinical data exist on its potential effect on the quality of life (QOL) of these patients. Objective Our objective was to assess the QOL among CAROM patients reconstructed with free flap surgery. Materials and Methods This analysis studied 19 patients of CAROM who had maxillectomy and/or orbital exenteration defects reconstructed with free flaps at a tertiary care center. All these patients were free from any residual disease, as confirmed by tissue biopsy taken from the affected area. The QoL of these patients was assessed 1 week preoperatively and 4 to 6 months postoperatively using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-HN43) questionnaire module. Results There was a statistically significant improvement in 10 out of the total 19 parameters (p < 0.05) which include pain in the mouth, problems opening mouth, speech, swallowing, weight loss, dry mouth and sticky saliva, body image, fear of progression, social contact, and social eating. Conclusion The EORTC QLQ-HN43 questionnaire module presented a statistically significant improvement in the functional as well as psychological status of the CAROM patients undergoing reconstruction by free flap surgery.

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“…During the COVID-19 pandemic, a global surge of MCM cases was reported with the majority of cases stemming from India [ 13 ]. Numerous cases in low- and middle-income countries (LMIC) may have gone unreported to healthcare facilities, resulting in limited representation in the published literature.…”

Section: Introductionmentioning

confidence: 99%

Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

Allaw,

Zakhour,

Nahhal

et al. 2023

JoF

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Mucormycosis (MCM) is a serious invasive fungal disease (IFD) that is associated with high mortality, particularly in immunocompromised patients. A global surge in MCM cases was reported with the COVID-19 pandemic. We analyzed all recorded cases of MCM at the American University of Beirut Medical Center (AUBMC), a tertiary care center in Lebanon, over 14 years. We aimed to identify the incidence, seasonal variation, clinical characteristics of the patients, and predictors of mortality. We conducted a retrospective chart review between 1 January 2008 and 1 January 2023. All patients with proven or probable MCM were included in the study. Proven or probable MCM was defined by positive histopathology and/or positive cultures. A total of 43 patients were identified as having MCM. Their median age was 53 years, and the majority were males (58.1%). Most of the cases were diagnosed in the autumn season. In total, 67.4% of the patients had hematological malignancies (HMs), and 34.9% had uncontrolled diabetes mellitus (DM). The most common site of involvement was rhino-orbital-cerebral MCM (ROCM) (74%). The annual cases of MCM per 100,000 patient days increased markedly during the years of the COVID-19 pandemic (from 0 to 4.4 cases/100,000 patient days to 7.5 cases/100,000 during 2020 and 2021). Liposomal amphotericin (Ampho) B was used as a first-line agent in most of the patients (86%). The median duration of total in-hospital antifungal therapy was 21 days and 51.2% of the patients received step-down therapy with azoles. Surgical debridement and isolated ROCM were significantly associated with survival (p-value: 0.02 and <0.001, respectively). All-cause mortality was 46.7%, with chronic renal disease being significantly associated with mortality (p-value < 0.05). The incidence of MCM has been increasing at our institution, particularly since the COVID-19 pandemic. Early diagnosis, treatment, and surgical debridement improve patient outcomes and overall survival.

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The Past, Present and Future of COVID-19 Associated Mucormycosis: A Rapid Review

Cited by 8 publications

References 38 publications

Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics

Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics

Restoring Quality of Life: Assessing the Impact of Free Flap Reconstruction in Coronavirus Disease 2019-Associated Rhino-Orbital Mucormycosis Patients

Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

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