The Pathology of Neck Dissection in Cancer of the Larynx

Devaney, Sarah; Ferlito, Alfio; Rinaldo, Alessandra; Devaney, Kenneth O.

doi:10.1159/000027747

Cited by 21 publications

(11 citation statements)

References 74 publications

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“…28 Studies have shown that routine evaluation misses up to 21% of disease nodes. It is suggested that SSS with H&E and IHC, and molecular methods may help to identify smaller metastatic deposits.…”

Section: Discussionmentioning

confidence: 99%

Sentinel Node Biopsy in Larynx Cancer: 5 Years Follow-up

Carvalho¹,

Guimarães

Surgery³

2015

Otolaryngol Open J

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Background: The management of the clinically and radiologically negative neck in patients with early Head and Neck Squamous Cell Carcinoma (HNSCC) is still controversial. As approximately 20 to 30% of these patients harbor occult disease in the neck, most of them have to undergo elective neck dissection with no great benefit to majority of them. Sentinel Lymph Node Biopsy (SLNB) is emerging as a potential method for staging of lymphatic metastasis in HNSCC. It has been demonstrated that the status of the sentinel node predicts the presence of metastasis in the remainder of the nodes within the nodal basin. Objective: To evaluate the accuracy of method in squamous cell carcinoma of larynx and compare neck status between Sentinel Node Biopsy (SNB) followed by Elective Neck Dissection (END) and SLNB alone. Results: Eighteen patients, 12 at glottis and in 6 supraglottis with a mean age of 63 years (49-83) were evaluated. The follow-up was 64 months (48-87), sentinel node was identified in all the patients and it was positive in four patients (22%). Five patients (27%) received postoperative radiotherapy because of local factors such as: positive margin, vascular invasion, perineural invasion or extra-capsular spread. During the follow-up period none of the patients had local or neck recurrence (0%). In the last evaluation none of the patients had local or neck recurrence. Conclusion: Sentinel Node Biopsy (SNB) in larynx cancer shows negative predictive value of 100%, accuracy of 100% and recurrence rate of 0%. It is important to note that no randomized study of sufficient sample size and sensitivity exists in the literature, but preliminary studies shows a new perspective in head and neck cancer.

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Section: Discussionmentioning

confidence: 99%

Sentinel Node Biopsy in Larynx Cancer: 5 Years Follow-up

Carvalho¹,

Guimarães

Surgery³

2015

Otolaryngol Open J

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“…19 This, in reality, is an incomplete examination, where central sections serve as a proxy for the whole node. If deposits were small and present in other regions of the node, they would be missed.…”

Section: Discussionmentioning

confidence: 99%

Pathologic evaluation of sentinel lymph nodes in oral squamous cell carcinoma

et al. 2010

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“…Traditionally, this term has been used to describe nodal disease detected not by clinical investigation, but by conventional histopathological examination of the neck dissection specimens (7). These metastatic deposits are small enough to evade detection by both palpation and radiographic examinations.…”

Section: The Status Of Cervical Lymph Nodesmentioning

confidence: 99%