The pathology of total joint arthroplasty

Bauer, Thomas W.; Schils, Jean

doi:10.1007/s002560050541

Cited by 157 publications

(97 citation statements)

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“…Aseptic loosening is the culmination of complex events triggered when implant wear debris, composed of materials such as polyethylene, cobaltchrome, titanium, silicone, or polymethylmethacrylate, is generated at various implant, implant-bone, or cement-bone motion interfaces. 1,2 The particulate debris activates synovial macrophages which then stimulate various inflammatory and destructive mediators including prostaglandins, cytokines, interleukins, collagenase, and tumor necrosis factor. 3,4 The inflammatory mediators, in turn, cause osteoclast activation, resorption of adjacent bone, and osteolysis.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The inflammatory mediators, in turn, cause osteoclast activation, resorption of adjacent bone, and osteolysis. [1][2][3][4][5] Aseptic loosening results when bone resorptive activity exceeds the reparative processes in surrounding cells and tissues. Although the principal cellular and mediator components of the destructive cascade leading to aseptic loosening have been identified, the molecular mechanism(s) by which wear debris triggers osteolysis is unknown.…”

Section: Introductionmentioning

confidence: 99%

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In situ complement activation by polyethylene wear debris

DeHeer

Engels

DeVries

et al. 2000

J. Biomed. Mater. Res.

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A frequent long-term complication of total joint arthroplasty is aseptic loosening, the end result of wear debris accumulation, synovitis, and osteolysis about the implant-bone or cement-bone interface. Complement, an effector system in plasma, synovial fluid, and tissue, has powerful chemotactic, inflammatory, and osteoclast-activating potentials. This study explored the complement-activating ability of polyethylene, a material used in joint implants. In vitro hemolytic assays using sheep red blood cells (E(sh)), human serum, and particulate polyethylene suggested alternative pathway complement activation, as well as polyethylene adsorption of activated complement components. These results were confirmed by enzyme-linked immunosorbent assay (ELISA) quantification of activated complement factors Bb and C3b. In situ double antibody immunoperoxidase staining for factors Bb, C3a, iC3b, and SC5-9 in synovial tissue from revision hip specimens showed localized alternative pathway activation and component adsorption. These results introduce a likely role for complement activation in particle-mediated recruitment, proliferation, and activation of macrophages during early events in osteolysis and implant loosening.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In situ complement activation by polyethylene wear debris

DeHeer

Engels

DeVries

et al. 2000

J. Biomed. Mater. Res.

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“…Although titanium-based implants can function effectively for a decade, the long-term clinical success of these devices is limited by implant loosening and wear, especially in younger patients. [1,2] Considerable efforts have focused on implant surface technologies, such as designing rough, porous coatings for bone ingrowth, and bone-bonding ceramic coatings to promote integration into the surrounding bone and thereby enhance mechanical interlock. [1,3,4] However, slow rates of osseointegration, particularly in clinically challenging cases, currently restrict these approaches.…”

mentioning

confidence: 99%

“…[1,2] Considerable efforts have focused on implant surface technologies, such as designing rough, porous coatings for bone ingrowth, and bone-bonding ceramic coatings to promote integration into the surrounding bone and thereby enhance mechanical interlock. [1,3,4] However, slow rates of osseointegration, particularly in clinically challenging cases, currently restrict these approaches. Biomimetic coatings, focusing on the presentation of biologically active molecules within a protein adsorption-resistant background, have recently emerged as a promising strategy to enhance osseointegration.…”

mentioning

confidence: 99%

Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides

et al. 2007

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Titanium and its alloys represent a major class of materials employed in orthopedic and dental clinical applications. Although titanium-based implants can function effectively for a decade, the long-term clinical success of these devices is limited by implant loosening and wear, especially in younger patients. [1,2] Considerable efforts have focused on implant surface technologies, such as designing rough, porous coatings for bone ingrowth, and bone-bonding ceramic coatings to promote integration into the surrounding bone and thereby enhance mechanical interlock. [1,3,4] However, slow rates of osseointegration, particularly in clinically challenging cases, currently restrict these approaches. Biomimetic coatings, focusing on the presentation of biologically active molecules within a protein adsorption-resistant background, have recently emerged as a promising strategy to enhance osseointegration.[5]Self-assembled monolayers (SAMs) have been explored as a method to control biologically related surface properties such as cell adhesion. [6][7][8][9][10] For example, we have previously demonstrated control over protein adsorption and cell adhesion and function by modification of oligo(ethylene glycol)-substituted alkanethiol monolayers on gold with specific peptide sequences from adhesion proteins. [11][12][13] However, SAMs on gold and silver substrates suffer from long-term instability and loss of bioresistance, and there are severe limitations to the application of robust noble-metal coatings on biomedical materials. [6][7][8][9] To overcome these shortcomings, several groups have concentrated on the engineering of polymeric films on titaniumand silicon-based surfaces to promote robust bioresistance. [14][15][16][17] For instance, adsorption of end-functionalized poly(ethylene glycol) (PEG) onto titanium metal (i.e., a "grafting-to" approach to prepare polymer brushes) affords resistance to protein adsorption.[10] More recently, a "graftingfrom" approach was developed based on surface-initiated atom-transfer radical polymerization (SI-ATRP) of oligo(ethylene glycol)methacrylate (OEGMA) on gold modified with a thiol monolayer of an a-bromo ester initiator. An extensive study of the properties of these brushes was carried out as a function of polymerization time and the surface density of initiator. This afforded the ability to control the thickness of the poly(OEGMA) film and demonstrated the resistance of these surfaces to cell adhesion. [9,16,18] To build on these findings and to explore the development of stable surface modifications of titanium, we set out to establish routes to prepare protein-adsorption-resistant polymer brushes that can be modified with peptide sequences that direct cell adhesion. We describe an approach to modify the surface of titanium with dense polymer brushes of poly(OEGMA) that resist protein adsorption and cell attachment. Furthermore, conversion of the hydroxyl end groups of the oligo(ethylene glycol) (OEG) side chains to 4-nitrophenyl carbonate groups allows for tethering of bioacti...

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“…It could be potential for bone cement, filling the bone defect, a coating of joint replacement and dental implant [1]. Several studies concerning [HA/PMMA] as bone cement have also been done by previous investigators [2,3,4,5]. In this composite, size and shape of particles may affect the mechanical properties of bone cement [6,7] although it depends on the percentage of its composition.…”

Section: Introductionmentioning

confidence: 99%

Composite of [HA/PMMA] for 3D-printer material application

Tontowi¹,

Kuswanto²,

Sihaloho³

2016

AIP Conference Proceedings

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Abstract. Synthetic hydroxyapatite (HA) and polymethylmethacrylate (PMMA) are among biomaterials that individually has been used in bone defect restoration. Pure HA powder is bioactive and biocompatible material, but it was difficult to be shaped into certain geometry as needed in many cases of restoration. While, PMMA may cause necrosis at the bonecement interface due to the heat released during polymerization. In shaping technology, a 3D Printer technology is capable to cope a complex geometry and shape, but it is recently only dedicated for the non-medical application. In this study, HA was composed with PMMA to form biocomposite that potentially applicable as a feeder material of the 3D Printer. PMMA powder was blended with various concentration of MMA liquid (40, 45, 50, 55 and 60% v/w) to form PMMA pasta. This pasta was then composed of HA (powder) in various ratios (10, 20 and 30% w/w) and cast into a specimen mold. Tests were performed to observe diametral tensile strength and solidification time relevant to the need of printing application. Results show that increasing MMA within PMMA could make longer solidification time and reduce its tensile strength. Although, HA within PMMA may reduce the composite tensile strength, but it could improve its solidification time and important to improve its bioactive and osteoconductivity and even to speed up solidification process that needed in faster printing.

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The pathology of total joint arthroplasty

Cited by 157 publications

References 0 publications

In situ complement activation by polyethylene wear debris

In situ complement activation by polyethylene wear debris

Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides

Composite of [HA/PMMA] for 3D-printer material application

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