The Pathway from Anatomy and Physiology to Diagnosis: A Developmental Perspective on Swallowing and Dysphagia

Mayerl, Christopher J.; Gould, François D. H.; Adjerid, Khaled; Edmonds, Chloe E; German, Rebecca Z.

doi:10.1007/s00455-022-10449-x

Cited by 11 publications

(13 citation statements)

References 103 publications

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“…Alternatively, infants with feeding difficulties are often fed milk with increased viscosity, which reduces the frequency of aspiration (Cichero et al, 2013;Newman et al, 2016). One limitation of these interventions is that they do not necessarily treat the underlying etiologies that generate feeding difficulties (Mayerl et al, 2022). For example, many of the feeding issues common in preterm infants involve poor abilities to generate suction (Dodrill, 2011;Lau, 2015;Mayerl et al, 2019) Furthermore, as the maturation of sucking patterns is an important neurological milestone in infant development (Gewolb et al, 2001;Lau et al, 2000), modulating stiffness has the potential to improve…”

Section: Implications For the Neuromotor Control Of Infant Feeding An...mentioning

confidence: 99%

“…Although we know that sensorimotor feedback plays an important role in infant feeding, we lack insight into the structures and mechanisms by which the motor system of infants responds to variations in sensory information. Identifying which structures involved in suckling can be altered by sensory manipulation will promote a better understanding of the neural control of feeding (Mayerl et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…These modifications have been suggested to improve feeding performance (Nowak et al, 1994; Pados et al, 2015). However, the relationship between passive flow rates and the physiological deficits underlying feeding difficulties are poorly understood (Mayerl et al, 2022). The active flow rate during infant feeding results from a combination of passive flow rate and suction generation (German et al, 1997; Lau, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Identifying which structures involved in suckling can be altered by sensory manipulation will promote a better understanding of the neural control of feeding (Mayerl et al, 2022).…”

mentioning

confidence: 99%

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Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model

et al. 2023

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Infant feeding is a critical neurological milestone in development defined by the coordination of muscles, peripheral nerves, and brainstem nuclei. In infants, milk flow rate is often limited to improve feeding performance without treating the underlying deficiencies in the sucking and swallowing processes. Modification of the neuromotor response via sensory information from the nipple during bottle feeding is an unexplored avenue for physiology‐based interventions. In this study, we assessed how differences in nipple hole size and nipple stiffness affect sucking muscle activation and subsequent movement. We fabricated four bottle nipples of varying hole size and stiffness to determine how variation in nipple properties affects the sucking behavior of infant pigs. Our results demonstrate that sensory information from the nipple affects sucking motor output. Nipple hole sizes and stiffnesses with a larger milk flow rate resulted in greater muscle activity and kinematic movement. Additionally, our results suggest that sensorimotor interventions are better directed toward modulating tongue function rather than the mandible movements due to a greater response to sensory information. Understanding how sensory information influences infant feeding is instrumental in promoting effective infant feeding.

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Section: Implications For the Neuromotor Control Of Infant Feeding An...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Identifying which structures involved in suckling can be altered by sensory manipulation will promote a better understanding of the neural control of feeding (Mayerl et al, 2022).…”

mentioning

confidence: 99%

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Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model

et al. 2023

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“…Lind et al, 2007), they are available for gene editing (Lind et al, 2007), and a lot of research has focused on neural development in piglets and implications for human infants (Conrad et al, 2012;Dickerson et al, 1971;Fanous et al, 2020;Leyshon et al, 2016;Mudd and Dilger, 2017;Radlowski et al, 2014). The piglet model has enabled progress with regard to the research of respiratory problems (Spengler et al, 2019;Williams and Galvis, 1974), metabolic issues (Mellor and Cockburn, 1986;Mota-Rojas et al, 2011;Vanden Hole et al, 2019), mastication and gut (un-)health (Che et al, 2010;Cilieborg et al, 2011;D'Inca et al, 2011;Mayerl et al, 2023a;Sangild et al, 2006;Vanden Hole et al, 2021).…”

Section: Piglets Baboons and Humansmentioning

confidence: 99%

Methodological Advances in Studying Postnatal Locomotor Development

Mielke¹

2023

Preprint

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We study piglet locomotion, attempting to falsify a difference that is due to birth weight category.This requires a methodological foundation on topics unfamiliar to most Biologists (Fourier Analysis, probabilistic models), which I introduce in dedicated chapters._Part I: Kinematic Analysis_+ I will introduce Fourier Methods with a practical guide and review its occurrence specifically in the field of locomotor biomechanics (Ch. 2).+ The power of Fourier tools is then unleashed onto a large cross-species study that covers most of the ungulate clade (Ch. 3, Mielke et al., 2019)._Part II: Probabilistic Modeling_+ Processing complex kinematic data, I will introduce the basics of probabilistic modeling (Ch. 4) in a "tiny textbook of statistics"...+ ... before turning around the conventional modeling strategy and applying it to piglets (Ch. 5, Mielke et al., 2023)._Part III: Dynamics_+ Kinematics are just half of locomotor research: the study of forces and moments is reviewed and summarized in another overview chapter (Ch. 6).+ To calculate joint moments, one needs to measure inertial properties, yet it turns out that these are not trivial to retrieve from x-ray tomographic images (Ch. 7).The thesis closes with a general discussion to round up and project the presented work to potential future applications (Ch. 8).

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The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model

Steer,

Johnson,

Edmonds

et al. 2023

Dysphagia

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The Pathway from Anatomy and Physiology to Diagnosis: A Developmental Perspective on Swallowing and Dysphagia

Cited by 11 publications

References 103 publications

Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model

Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model

Methodological Advances in Studying Postnatal Locomotor Development

The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model

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