The PECAM-1 gene polymorphism — a genetic marker of myocardial infarction

Reschner, Hrvoje; Milutinović, Aleksandra; Petrovič, Danijel

doi:10.2478/s11535-009-0042-0

Cited by 4 publications

(5 citation statements)

References 28 publications

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Section: Discussionmentioning

confidence: 99%

“…There were significant differences of PECAM1 genotype distribution in patients with MI compared with subjects in the control group, which suggest that polymorphism of PECAM1 (C373G) may be a genetic marker of MI in T2DM patients. 47 Several limitations existed in our study. Firstly, our results in this study mainly derived from microarray analysis that based on gene expression value, which may be not directly equivalent to the protein expression.…”

Section: Dovepressmentioning

confidence: 92%

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Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI

Li¹,

Liu²

2021

IJGM

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Background Type 2 diabetes mellitus (T2DM), a major risk factor of coronary heart disease, is associated with an approximately twofold increase in the risk of myocardial infarction (MI). We studied co-expressed genes to demonstrate relationships between DM and MI and revealed the potential biomarkers and therapeutic targets of T2DM-related MI. Methods DM and MI-related differentially expressed genes (DEGs) were identified by bioinformatic analysis, Gene Expression Omnibus (GEO) datasets GSE42148 and GSE61144 of MI patients, and the normal control and GSE26168 and GSE15932 of DM patients and normal controls, respectively. Further target prediction and network analysis method were used to detect protein-protein interaction (PPI) networks, gene ontology (GO) terms, and pathway enrichment of DEGs. Co-expressed DEGs of T2DM-related MI were analyzed as well. Results We identified 210 upregulated and 127 downregulated DEGs in T2DM, as well as 264 upregulated and 242 downregulated DEGs in MI. Eighteen upregulated and four downregulated DEGs were identified as co-DEGs of T2DM and MI. Functional analysis revealed that T2DM-related DEGs were mostly enriched in the viral process and ubiquitin-mediated proteolysis, while MI-related DEGs were mostly enriched in protein phosphorylation and TNF signaling pathway. MPO , MMP9 , CAMP , LTF , AZU1 , DEFA4 , STAT3 , and PECAM1 were recognized as the hub genes of the co-DEGs with acceptable diagnostic values in T2DM and MI datasets. Adenosine receptor agonist IB-MECA was predicted to be a potential drug for T2DM-related MI with the highest CMap connectivity score. Conclusion Our study identified that the co-DEGs of MPO , MMP9 , CAMP , LTF , AZU1 , DEFA4 , STAT3 , and PECAM1 are significantly associated with novel biomarkers involved in T2DM-related MI. However, more experimental research and clinical trials are demanded to verify our results.

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Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 92%

Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI

Li¹,

Liu²

2021

IJGM

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“…Reschner et al . [ 17 ] reported an association between the PECAM-1 rs668 (the CC genotype) and MI in Caucasians with T2DM. Finally, the effect of several polymorphisms of the PECAM-1 gene on cardiovascular disease was confirmed by Listi et al .…”

Section: Discussionmentioning

confidence: 99%

“…This polymorphism might affect the homophilic binding capability and influence individual susceptibility to the development of atherosclerosis. The association between the rs668 PECAM-1 polymorphism and cardiovascular disease was studied in Caucasians [ 17 - 19 ], Japanese [ 20 ] and Chinese [ 21 ], but no clear answer on the association between the rs668 polymorphism of PECAM-1 and the development of cardiovascular diseases could be provided.…”

Section: Introductionmentioning

confidence: 99%

PECAM-1gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Popovic

Starčević

Letonja

et al. 2016

Balkan Journal of Medical Genetics

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The platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important role in many inflammatory processes, including the development of atherosclerosis. Polymorphism rs668 of the PECAM-1 gene (373C/G) is functional, and it was reported to be associated with increased serum levels of PECAM-1. We investigated the association between the rs668 polymorphism of PECAM-1 and subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Geno-typing of the PECAM-1 gene polymorphism (rs668) was performed using KASPar assays. The control examinations were performed 3.8 ± 0.5 years after the initial examination. Higher CIMT was found in patients with T2DM in comparison with subjects without T2DM. Statistically sig-nificantly faster progression of the atherosclerotic markers was shown in subjects with T2DM in comparison with the control group. When adjusted to other risk factors, the rs668 GG genotype was associated with an increased risk of carotid plaques in subjects with T2DM. We concluded that our study demonstrated a minor effect of the rs668 PECAM-1 on markers of carotid atherosclerosis in subjects with T2DM.

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“…Notably, our study group was earlier able to confirm an association between Leu125Val polymorphism and myocardial infarction in subjects with T2DM [21]. As patients with DN have a substantially increased risk of developing cardiovascular complications, we hypothesized that PECAM-1 may be an important factor involved in both micro- and macrovascular pathogenesis of T2DM.…”

Section: Introductionmentioning

confidence: 88%

PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

Završnik

Kariž

Makuc

et al. 2016

Analytical Cellular Pathology

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Objectives. Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. We hypothesized that genetic variation in PECAM-1 gene could be associated with diabetic nephropathy (DN) and with the level of soluble PECAM-1 in Caucasians with type 2 diabetes mellitus (T2DM). Design and Methods. We analyzed the rs688 single nucleotide polymorphism of PECAM-1 gene C373G (Leu125Val) at exon 3, which encodes the first extracellular Ig-like domain that mediates the homophilic binding of PECAM-1, in 276 T2DM subjects with documented DN (cases) and 375 T2DM subjects without DN (controls), using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy. Level of plasma soluble PECAM-1 (sPECAM-1) was measured by ELISA in a subpopulation of 120 diabetics with DN. Results. We found no association between the Leu125Val polymorphism and DN in subjects with T2DM. Likewise, the Leu125Val polymorphism was not associated with serum sPECAM-1 levels in a subpopulation of 120 diabetics with DN. Conclusion. The Leu125Val polymorphism of PECAM-1 and the level of sPECAM-1 are not associated with DN in T2DM subjects of Slovenian origin.

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The PECAM-1 gene polymorphism — a genetic marker of myocardial infarction

Cited by 4 publications

References 28 publications

Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI

Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI

PECAM-1gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

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