The peculiar dissolution behaviour of Piretanide hosted in layered double hydroxides

Guagliano, Marianna; Monteforte, Francesco; Bruni, Giovanna; Friuli, Valeria; Maggi, Lauretta; Quinzeni, Irene; Bini, Marcella

doi:10.1016/j.clay.2020.105826

“…Thermal data, in particular the melting or decomposition temperatures of drugs, can be employed to prove the formation of new compounds, because of drug adsorption [6][7][8]. The DSC curves of Fur, HAP-Pure-Fur, and HAP-Sr-Fur are reported in Fig.…”

Section: Physico-chemical Characterizationmentioning

confidence: 99%

“…The design of suitable systems having complex architectures or composite materials is a quite new and appealing strategy applied in many different fields, from water purification to food and sensors [1][2][3]. In particular, in the pharmaceutical industry, the materials constituted by host inorganic matrices and drug guests have attracted considerable attention and represent one of the latest research strategies in the development of new drug alternatives [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

¹

,

Rinaldi

²

,

Bruni

³

et al. 2022

J Inorg Organomet Polym

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In the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.

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“…Thermal data, in particular the melting or decomposition temperatures of drugs, can be employed to prove the formation of new compounds, because of drug adsorption [3][4][5]. The DSC curves of Fur, HAP-Pure-Fur, and HAP-Sr-Fur are reported in Figure 3.…”

Section: Physico-chemical Characterizationmentioning

confidence: 99%

“…The search for effective systems increasing the bioavailability of drugs by improving the physicochemical and/or biopharmaceutical properties is a fascinating and forefront topic, particularly appealing for poorly soluble drugs administered in oral form, the most common way for chronic therapies requiring repeated administrations. The design of materials constituted by host inorganic matrices and drug guests has attracted considerable attention and is one of the latest research strategies in the development of new drug alternatives in the pharmaceutical industry [1][2][3][4][5]. Furosemide (Fur), 4-chloro-2-[(2-furanylmethyl)-amino]-5-sulfamoylbenzoic acid, is a high ceiling loop diuretic drug to treat edema and hypertension linked to congestive heart failure, cirrhosis of the liver and renal disease.…”

Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic-Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca¹,

Rinaldi²,

Bruni³

et al. 2022

Preprint

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0

View full text Add to dashboard Cite

In the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.

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“…The best approach is to increase the dissolution rate of the poorly soluble drug at the different pHs (so that the solubility could be no longer pH-dependent) and only then to control its release properties from the pharmaceutical form. Many approaches have been used to make the drug more available in dissolution, such as the preparation of co-crystals [ 7 , 8 ], hybrid compounds [ 9 , 10 , 11 ], amorphous solid dispersions [ 12 ] drug-cyclodextrin complex [ 13 ] and supercritical carbon dioxide-based techniques [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Tablet Formulations of Polymeric Electrospun Fibers for the Controlled Release of Drugs with pH-Dependent Solubility

Friuli

¹

,

Pisani

²

,

Conti

³

et al. 2022

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A challenge in the pharmaceutical sector is the development of controlled release dosage forms for oral administration of poorly soluble drugs, in particular, drugs characterized by pH-dependent solubility through the gastrointestinal tract, which itself shows wide variability in terms of environmental pHs. The best approach is to increase the dissolution rate of the drugs at the different pHs and only then modify its release behavior from the pharmaceutical form. This work aims to demonstrate the ability of properly designed polymeric nanofibers in enhancing the release rate of model drugs with different pH-dependent solubility in the different physiological pHs of the gastrointestinal tract. Polymeric nanofibers loaded with meloxicam and carvedilol were prepared using the electrospinning technique and were then included in properly designed tablet formulations to obtain fast or sustained release dosage forms. The nanofibers and the tablets were characterized for their morphological, physico-chemical and dissolution properties. The tablets are able to deliver the dose according to the expected release behavior, and zero-order, first-order, Higuchi, Korsmeyer–Peppas and Hixon–Crowell kinetics models were used to analyze the prevailing release mechanism of the tablets. This study shows that the electrospun fibers can be advantageously included in oral dosage forms to improve their release performances.

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The peculiar dissolution behaviour of Piretanide hosted in layered double hydroxides

Cited by 9 publications

References 28 publications

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

New Emerging Inorganic-Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Tablet Formulations of Polymeric Electrospun Fibers for the Controlled Release of Drugs with pH-Dependent Solubility

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