The PedsQL™ Multidimensional Fatigue Scale in pediatric obesity: Feasibility, reliability and validity

Varni, James W.; Limbers, Christine A.; Bryant, William R.; Wilson, Don E.

doi:10.1080/17477160903111706

Cited by 32 publications

(70 citation statements)

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“…Fatigue: children/adolescents undergoing HSCT both affected by oncological or non‐oncological diseases can experience severe fatigue that can reduce their involvement in daily activities and QoL. Fatigue was evaluated both in parents and participants with the PedsQLTM Multidimensional Fatigue Scale (Varni et al, 2002; Varni et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rossi

Zucchetti

Esposito

et al. 2022

European J Cancer Care

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Objectives The aim of this pilot trial is evaluating the preliminary effectiveness of two in‐hospital interventions in the maintenance of motor performance in children/adolescents undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives investigated the interventions' feasibility, impact on fatigue and to what degree the subjects' maintained their ankle dorsiflexion range of movement (ROM), functional mobility, muscle strength and flexibility. Methods This trial included 5‐ to 18‐year‐old participants, affected by oncological and non‐oncological diseases during hospitalisation for autologous/allogenic HSCT. The subjects were assigned to an exercise group (EG), or a counselling group based on a cluster model based on inpatient timeframe. The EG subjects performed strengthening, stretching and aerobic exercises for 30 min/5 days a week. Both groups followed rehabilitation counselling indications (RCI), 7 days a week. Results Forty‐nine participants were enrolled (median age = 12.9 years) (EG n = 36). In both groups the participants maintained their baseline motor performance and ankle ROM, and the children/adolescents and parents reduced their levels of fatigue. However, the interventions were not effective in maintaining strength. Conclusion In maintaining the subjects' motor performance, the RCI results are significant because they pave the way for the application in clinical practice contexts where there are poor rehabilitation resources. Clinical Trials registration NCT03842735.

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Section: Methodsmentioning

confidence: 99%

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rossi

Zucchetti

Esposito

et al. 2022

European J Cancer Care

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“…To facilitate best clinical practice for the prevention and management of fatigue in children and adolescents with DMD, an understanding of patients’ and parents’ perspectives of fatigue is needed. Parents’ perceptions of their child's health influences healthcare utilization — particularly when the child is too young, too cognitively impaired, or too ill to self‐manage his or her own health . This study aimed to describe fatigue in DMD from patients’ and parents’ perspectives, and to explore associations of patient characteristics with child/adolescent self‐reported and parent proxy‐reported fatigue.…”

mentioning

confidence: 99%

Fatigue in young people with Duchenne muscular dystrophy

El-Aloul

Speechley

Wei

et al. 2019

Develop Med Child Neuro

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AIM To describe fatigue in Duchenne muscular dystrophy (DMD) from patients' and parents' perspectives and to explore risk factors for fatigue in children and adolescents with DMD.METHOD A multicentre, cross-sectional study design was used. Seventy-one patients (all males; median age 12y, age range 5-17y) identified via the Canadian Neuromuscular Disease Registry, and their parents completed questionnaires. Subjective fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale by child self-report and parent proxy-report. RESULTSPatients with DMD across ages and disease stages experienced greater fatigue compared to typically developing controls from published data. Sleep disturbance symptoms were associated with greater fatigue by child self-report (q=-0.42; p=0.003) and parent proxyreport (q=-0.51; p<0.001). Depressive symptoms were associated with greater fatigue by child self-report (q=-0.46; p<0.001) and parent proxy-report (q=-0.45; p<0.001). Lower functional ability was associated with greater fatigue by parent proxy-report (q=0.26; p=0.03). Physical activity level, and musculoskeletal, respiratory, and cardiac function were not associated with fatigue.

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“…After 24 weeks of treatment, large increases (corresponding to improvement) in fatigue scores, most notably in cognitive fatigue, brought subject B8 into the range reported for that of healthy children. 19,20 Four subjects, A11, A7, C1, and C5, showed variable improvement in fatigue. Subject A7 reported no difficulty with sleep-related fatigue at baseline, which did not change with treatment, but showed substantial improvement in cognitive fatigue.…”

Section: Fatiguementioning

confidence: 99%

Individual heat map assessments demonstrate vestronidase alfa treatment response in a highly heterogeneous mucopolysaccharidosis VII study population

et al. 2019

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Mucopolysaccharidosis (MPS) VII is an ultra‐rare, progressively debilitating, life‐threatening lysosomal disease caused by deficiency of the enzyme, β‐glucuronidase. Vestronidase alfa is an approved enzyme replacement therapy for MPS VII. UX003‐CL301 was a phase 3, randomized, placebo‐controlled, blind‐start study examining the efficacy and safety of vestronidase alfa 4 mg/kg intravenously administered every 2 weeks to 12 patients with MPS VII. Due to the rarity of disease, broad eligibility criteria resulted in a highly heterogeneous population with variable symptoms. For an integrated view of the diverse data, the changes from baseline (or randomization for the placebo period) in clinical endpoints were grouped into three functional domains (mobility, fatigue, and fine motor + self‐care) and analyzed post‐hoc as subject‐level heat maps. Mobility assessments included the 6‐minute walk test, 3‐minute stair climb test, Bruininks‐Oseretsky test (BOT‐2) gross motor function subtests, and patient‐reported outcome assessments (PROs) related to movement, pain, and ambulation. Fatigue assessments included the Pediatric Quality of Life Multidimensional Fatigue Scale and other fatigue‐related PROs. Fine motor + self‐care assessments included BOT‐2 fine motor function subtests and PROs for eating, dressing, hygiene, and caregiver assistance. Most subjects showed improvement in at least one domain. Two subjects improved in two or more domains and two subjects did not show clear improvement in any domain. Both severely and mildly affected subjects improved with vestronidase alfa in clinical assessments, PRO results, or both. Heat map analysis demonstrates how subjects responded to treatment across multiple domains, providing a useful visual tool for studying rare diseases with variable symptoms.

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The PedsQL™ Multidimensional Fatigue Scale in pediatric obesity: Feasibility, reliability and validity

Cited by 32 publications

References 0 publications

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance

Fatigue in young people with Duchenne muscular dystrophy

Individual heat map assessments demonstrate vestronidase alfa treatment response in a highly heterogeneous mucopolysaccharidosis VII study population

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