The Pepsin and Rennin Activity of Preparations of Dried Stomach from the Cardia, Fundus and Pylorus Respectively¹.

Abstract

Résumé. The pepsin and rennin activities of preparations of dried stomach from the cardia, fundus and pyloric areas respectively have been estimated. In excising material for these preparations, the anatomical distribution of the different gland elements in pig's stomachs (see Meulengracht and Søeborg Ohlsen) has been taken into account. It has been shown that the pepsin and rennin activities are considerable in preparations from the fundus area, but quite small in those from the cardia and pyloric areas. It can presumably be concluded from this that pepsin (and rennin) are secreted by the fundus gland organ, and by that alone. Pepsin (and rennin) and the antianaemic factor are dissociated physiologically and anatomically in the stomach. Consequently pepsin determinations must be used with caution as an indicator of the presence of the antianaemic factor in commercial preparations, but with this proviso the estimation is useful.