The PERFECT Study (PEnnel Real liFe Efficacy Clinical Trial), a Double-Blind, Randomized, Multicenter Trial Examining the Efficacy of Biphenyl Dimethyl Dicarboxylate Combined with Garlic Oil in Patients with Transaminase Elevated Chronic Liver Disease

Kim, Hyung Joon; Lee, June Sung; Lee, Hyun Woong; Kim, Mun Young; Nam, Soon Woo; Sohn, Jung Ho; Cho, Se Hyun; Yoon, Seung Gyu; Yang, Jin Mo; Park, Chung Kee; Rim, Gyu Sung; Lee, Young Sok

doi:10.3904/kjm.2014.86.2.179

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…198 potentially relevant articles are identified initially. Finally, four RCTs are included in the meta-analysis [17][18][19]26 . The baseline characteristics of four eligible RCTs in the meta-analysis are summarized in Table 1.…”

Section: Literature Search Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials

Xiaohui,

Jinqi,

Xiaofang

et al. 2023

Afr H. Sci.

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Introduction: The efficacy of garlic supplementation for chronic liver disease remains controversial. We conduct a meta-analysis to explore the influence of garlic supplementation versus placebo on the treatment of chronic liver disease. Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2021 for randomized controlled trials (RCTs) assessing the efficacy of garlic supplementation versus placebo for chronic liver disease. This meta-analysis is performed using the random-effect model. Results: Four RCTs and 212 patients are included in the meta-analysis. Overall, compared with control group for chronic liver disease, garlic supplementation is associated with significantly reduced alanine aminotransferase (ALT), aspartate-aminotransferase (AST), total cholesterol, low density lipoprotein (LDL) and weight, but demonstrates no substantial impact on the incidence of adverse events. Conclusions: Garlic supplementation is effective to treat chronic liver disease. Keywords: Garlic; chronic liver disease; randomized controlled trials; meta-analysis.

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Section: Literature Search Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials

Xiaohui,

Jinqi,

Xiaofang

et al. 2023

Afr H. Sci.

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Section: Dimethyl-44’-dimethoxy-565’6’-dimethylenedixoybiphenyl-22’-d...mentioning

confidence: 99%

“…The addition of garlic oil to DDB was recently evaluated in a double-blind RCT with 12 weeks of intervention ( Table 3 ) [ 110 ]. Kim et al [ 110 ] evaluated the beneficial effect on ALT normalization, improvement of quality of life, and safety of the DDB-garlic oil complex in patients with CLDs other than viral hepatitis. The rate of ALT normalization was 89% in the DDB–garlic oil complex group, which was significantly higher than that of the silymarin group (18.6%) or placebo group (22.9%) ( P <0.001).…”

Section: Dimethyl-44’-dimethoxy-565’6’-dimethylenedixoybiphenyl-22’-d...mentioning

confidence: 99%

“…The adverse events possibly related to DDB-garlic oil treatment were diarrhea, dry mouth, epigastric soreness, rash, and so on [ 111 ]. The rates of adverse events were not different compared to those of the placebo control group or active control (silymarin) group, and no serious adverse events occurred during the 12 weeks of the study period [ 110 ].…”

Section: Dimethyl-44’-dimethoxy-565’6’-dimethylenedixoybiphenyl-22’-d...mentioning

confidence: 99%

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Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

et al. 2022

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The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non–antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non–antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.

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“…[6] According to a double-blind, randomized, multicenter trial in Korea on the efficacy of DDB, ALT levels were normalized after >4 weeks, and AST levels were unchanged after 12 weeks. [8]…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of Injinoryung-San-Gagambang (Yinchen Wuling powder) decoction on stroke patients with elevated serum liver enzymes

et al. 2018

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Rationale:Injinoryung-San-Gagambang (IJORS) effectively improves hepatic dysfunction caused by polypharmacy in stroke patients.Patient concerns:We present 3 cases of hepatic dysfunction caused by polypharmacy, one of which was a 51-year-old man with cerebellum infarction and pneumonia as a complication of stroke. He took multiple medications because of baseline diseases. After recurrence of pneumonia, his laboratory tests showed abnormal aminotransferase levels. Another patient was an 81-year-old woman with cerebral infarction at the right-middle cerebral artery. She was also taking >5 medications. Her laboratory tests conducted on admission showed abnormally elevated aminotransferase levels. The last patient was 77-year-old man with cerebral infarction at the left-middle cerebral artery. He also had an abdominal aneurysm, a thoracic aortic aneurysm, and a myocardial infarction. After taking multiple medications including healthy functional foods, his laboratory tests showed abnormally elevated aminotransferase levels.Diagnosis:Diagnosis is conducted with the result of laboratory test including blood count, chemistry test.Interventions:All 3 patients received the same herbal treatment (IJORS decoction) for 1 to 3 weeks.Outcomes:All 3 patients’ abnormal serum aminotransferase level were significantly improved by IJORS decoction treatment while keeping other medicines.Lessons:IJORS can be considered as an effective treatment for hepatic dysfunction induced by numerous medications in stroke patients.

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The PERFECT Study (PEnnel Real liFe Efficacy Clinical Trial), a Double-Blind, Randomized, Multicenter Trial Examining the Efficacy of Biphenyl Dimethyl Dicarboxylate Combined with Garlic Oil in Patients with Transaminase Elevated Chronic Liver Disease

Cited by 5 publications

References 20 publications

Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials

Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials

Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

Effectiveness and safety of Injinoryung-San-Gagambang (Yinchen Wuling powder) decoction on stroke patients with elevated serum liver enzymes

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