This paper presents research on several factors influencing the stabbing behaviour of stratified panels made of aramid fabric Twaron® SRM509 Teijin Aramid BV (Arnhem, The Netherlands). The inputs in the test campaign were the number of layers, the impact energy, and the sample size. Tests were performed on small samples (130 mm × 130 mm) on an Instron® CEAST 9350 drop-tower impact system (Norwood, MA, USA) and on larger samples (400 mm × 400 mm) using a test installation with the same values of the impact energy. Knife type S1 was used, with the geometry recommended in NIJ Standard 0115.00 Stab Resistance of Body Armor SEM, and macro photography investigations revealed the failure mechanisms of panel, layers and fibres. A very important conclusion of this study regarding the stabbing performance of fabric Twaron® SRM 509 in particular, but also in general for panels for body protection is that a research study could start on small size samples, with an accurately instrumented machine, in order to establish the influence of significant factors of stab resistance (energy level, number of layers in a panel, etc.), as these samples are less expensive and less time consuming, but the study should be continued to examine larger size samples. The obtained data are useful for the prototype.