The performance of a hemostatic agent based on oxidized regenerated cellulose – polyglactin 910 composite in a liver defect model in immunocompetent and athymic rats

Muench, Tim; Kong, Weina; Harmon, Alex

doi:10.1016/j.biomaterials.2010.01.070

Cited by 15 publications

(7 citation statements)

References 10 publications

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“…Many protocols have been established to evaluate ORC materials 192021. Most of these protocols, however, involve application of a topical hemostatic material to separate animals, introducing the possibility that the different hemostatic capacity of each animal could affect bleeding.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

Kim

Yoon³

et al. 2017

Yonsei Med J

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PurposeAdequate hemostasis is important for postoperative outcomes of abdominal surgery. This study evaluated the hemostatic effects and accompanying histopathological changes of a novel oxidized regenerated cellulose, SurgiGuard®, during abdominal surgery.Materials and MethodsTen pigs underwent wedge resection of the spleen (1×1 cm) and liver (1.5×1.5 cm). The resected surface was covered with Surgicel® fabric or fibril type (Group A) or SurgiGuard® fabric or fibril type (Group B). Surgicel® and SurgiGuard® were randomized for attachment to the resected surface by fabric type (n=5) or fibril type (n=5). Blood loss was measured 5, 7, and 9 min after resection. Pigs were necropsied 6 weeks postoperatively to evaluate gross and histopathological changes.ResultsThere was no significant difference in total blood loss between groups [spleen fabric: Group A vs. Group B, 4.38 g (2.74–6.43) vs. 3.41 g (2.46–4.65), p=0.436; spleen fibril: Group A vs. Group B, 3.44 g (2.82–6.07) vs. 3.60 g (2.03–6.09), p=0.971; liver fabric: Group A vs. Group B, 4.51 g (2.67–10.61) vs. 6.93 g (3.09–9.95), p=0.796; liver fibril: Group A vs. Group B, 3.32 g (2.50–8.78) vs. 3.70 g (2.32–5.84), p=0.971]. Histopathological analysis revealed no significant difference in toxicities related to Surgicel® or SurgiGuard® [inflammation, fibrosis, foreign bodies, and hemorrhage (spleen: p=0.333, 0.127, 0.751, and 1.000; liver: p=0.155, 0.751, 1.000, and 1.000, respectively)].ConclusionSurgiGuard® is as effective and non-toxic as Surgicel® in achieving hemostasis after porcine abdominal surgery.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

Kim

Yoon³

et al. 2017

Yonsei Med J

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“…These materials are also reported to be biodegradable via enzymatic (glycosidase‐based) and macrophagic processes . Recent advancement of these materials involves modification of the material matrix with other hemostatic agents like fibrin . Like cotton gauze and pads, the OC and ORC materials can present the issue of adherence to the bleeding tissue, that may pose some logistical difficulties during their subsequent removal.…”

Section: Hemostatic Biomaterials and Technologies For Topical (Externmentioning

confidence: 99%

Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding

et al. 2017

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Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders. In contrast, treatment of internal noncompressible hemorrhage still heavily depends on transfusion of whole blood or blood's hemostatic components (platelets, fibrinogen, and coagulation factors). Transfusion of platelets poses significant challenges of limited availability, high cost, contamination risks, short shelf-life, low portability, performance variability, and immunological side effects, while use of fibrinogen or coagulation factors provides only partial mechanisms for hemostasis. With such considerations, significant interdisciplinary research endeavors have been focused on developing materials and technologies that can be manufactured conveniently, sterilized to minimize contamination and enhance shelf-life, and administered intravenously to mimic, leverage, and amplify physiological hemostatic mechanisms. Here, a comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic technologies in terms of materials, mechanisms, and state-of-art is provided, and challenges and opportunities to help advancement of the field are discussed.

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“…Cellulose-based substrates represent a readily available, sustainable raw material for the production of blood-contacting biomaterials. Previous research has evaluated the use of cellulose-based structures, both modified and unmodified, as implantable materials with positive results [16,17,23]. In addition, cellulose structures possess surfaces with ample reaction groups for ALD chemistries; facile coating of these substrates using a variety of ALD processes may be achieved.…”

Section: Discussionmentioning

confidence: 99%

“…Some groups have investigated incorporating human-derived biologics within oxidized regenerated cellulose hemostatic agents. However, human-derived biologic-containing hemostatic agents elicited a cellular immune response in an immunocompetent murine model; decreases in material absorption, healing, and fibrin degradation were noted in athymic rats [17]. In addition, the human-derived components have problems related to disease transmission, anaphylactic reaction, and stability.…”

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confidence: 99%

Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

Hyde

Stewart

Scarel

et al. 2011

Biotechnology Journal

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TiO2 films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO2 films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO2 films were shown to profoundly alter the water contact angle values of cellulose depending upon processing characteristics. Higher rates of protein adsorption were noted on TiO2-coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.

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The performance of a hemostatic agent based on oxidized regenerated cellulose – polyglactin 910 composite in a liver defect model in immunocompetent and athymic rats

Cited by 15 publications

References 10 publications

Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding

Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

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