The peripheral hemodynamics of exogenously administered prostaglandin E1 during major venous occlusion in the dog

Maixner, William; Wright, Creighton B.; Jaffe, Bernard M.; Gall, Warren E.; Schoepfle, Walter J.

doi:10.1016/0022-4804(81)90014-7

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, cyclic GMP is associated with smooth muscle relaxation, which is a different mechanism of vasodilation mediated by the IP receptor [ 23 ]. PGE 1 also inhibits aggregation of platelets [ 24 ] and increases peripheral venous pressure [ 25 ] in experimental studies. In a clinical study, PGE 1 administration at a low infusion rate of 0.02 μg/kg/min increased cardiac output without altering mean arterial blood pressure and blood volume [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

Shirasaka

Takayama

Sekiguchi

et al. 2008

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Reduction of blood flow is important in the induction of neurogenic intermittent claudication (NIC) in lumbar spinal canal stenosis. PGE 1 improves the mean walking distance in patients with NIC type cauda equina compression. PGE 1 derivate might be effective in dilating blood vessels and improving blood flow in nerve roots with chronically compressed cauda equina. The aim of this study was to assess whether PGE 1 derivate has vasodilatory effects on both arteries and veins in a canine model of chronic cauda equina compression.

show abstract

Section: Discussionmentioning

confidence: 99%

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

Shirasaka

Takayama

Sekiguchi

et al. 2008

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…᭧ 1998 Academic Press E 1 (PGE 1 ) which is known to improve circulation and Key Words: amrinone; phosphodiesterase inhibitor; mi-has been used with success for treating some periphcrocirculation; hemodynamic; blood flow; flap survival. eral vascular diseases [2][3][4][5][6][7][8]. …”

mentioning

confidence: 99%

Amrinone, a Selective Phosphodiesterase III Inhibitor, Improves Microcirculation and Flap Survival: A Comparative Study with Prostaglandin E1

Ichioka¹,

Nakatsuka²,

Sato³

et al. 1998

Journal of Surgical Research

View full text Add to dashboard Cite

Clinical Use of Amrinone (a Selective Phosphodiesterase III Inhibitor) in Reconstructive Surgery

Ichioka

Nakatsuka

Ohura

et al. 2001

Plastic and Reconstructive Surgery

View full text Add to dashboard Cite

Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. It is effective in the treatment of congestive heart failure because of its ability to increase myocardial contractility and vascular smooth muscle relaxation. This study was designed to clarify the potential efficacy of amrinone in plastic surgery by clinically assessing its ability to enhance flap blood flow after reconstructive surgery and relieve intraoperative vasospasm. Its effects were compared with those of prostaglandin E1 and lidocaine, which are widely approved agents for improving the hemodynamics of flaps. In the first clinical study, the effects on flap blood flow after flap transfers were investigated. Twenty-six patients underwent reconstructive surgery with vascularized free or pedicled flaps. Blood flow was measured before and 60 minutes after intravenous infusion of lactated Ringer solution (control), amrinone (10 microg/kg/min), or prostaglandin E1 (10 ng/kg/min) using a laser Doppler flowmeter. In the second study, the effects on relief of vasospasm during operation were evaluated. The blood flow of 28 island flaps was measured by laser Doppler flowmetry immediately after flap elevation and 10 minutes after topical application of saline (control), amrinone (5 mg/ml), or lidocaine (10%) to the pedicle in an attempt to resolve the vasospasm. In both clinical studies, the effects of amrinone were statistically no less than those of prostaglandin E1 and lidocaine. The results show that amrinone positively influences the microcirculatory blood flow of transferred flaps and relieves intraoperative vasospasm in clinical cases. The present study suggests that amrinone could be useful for postoperative and intraoperative care in reconstructive surgery.

show abstract

The peripheral hemodynamics of exogenously administered prostaglandin E1 during major venous occlusion in the dog

Cited by 3 publications

References 8 publications

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equina

Amrinone, a Selective Phosphodiesterase III Inhibitor, Improves Microcirculation and Flap Survival: A Comparative Study with Prostaglandin E1

Clinical Use of Amrinone (a Selective Phosphodiesterase III Inhibitor) in Reconstructive Surgery

Contact Info

Product

Resources

About