The system size problems are the important component of the multi-particle dynamics, which, however, is not sufficiently taken into account in the cosmic ray researches. Therefore, in addition to a broad and important program of new сollider and target experiments to study the interactions of protons with light nuclei, we propose to consider the features of multi-particle processes on light nuclei. In the work these problems are studied in the centrality selected interactions of light-(C, O, Ne)-(beam) and heavy-(Au, Pb)-(beam) ions with light-(C/N/O)-(target) and heavy-(Ag/Br)-(target) nuclei on the data of JINR-AGS-SPS target emulsion experiments with limited statistics. In order to reveal the possible system structure dependence, the analyses of E-by-E fluctuations on the longitudinal event shape and multiplicity are performed in two directions: on vertically,-for different (beam-target) pairs of nuclei under certain impact parameters, and on horizontally,-for the same (beam-target) pairs of nuclei on different impact parameters. The strong fluctuation enhancement for the central collisions of (C, O, Ne)-beam + (C/N/O)-target was interpreted as the sign of intrinsic virtual alpha-clustering in light nuclei.