The PFOS disturbed immunomodulatory functions via nuclear Factor-κB signaling in liver of zebrafish (Danio rerio)

Guo, Jinshu; Wu, Panhong; Cao, Jianhua; Luo, Yu; Chen, Jianjie; Wang, Guodong; Guo, Wei; Wang, Tianyu; He, Xinjing

doi:10.1016/j.fsi.2019.05.018

Cited by 45 publications

(22 citation statements)

References 75 publications

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“…For instance, PFOS exposure disturbed the immune regulation of the liver of zebrafish via NF-κB signaling. 36 Likewise, significant inflammatory cell infiltration was observed in rat liver after PFOS exposure. 15 In the present study, we examined the histopathological changes in the liver specimens of rats following exposure to PFOS, and identified obviously increased vacuoles in the liver of PFOS-exposed rats.…”

Section: Discussionmentioning

confidence: 94%

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Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Wan

Ling

et al. 2022

Environmental Toxicology

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Perfluorooctane sulfonate (PFOS) is a widespread environmental pollutant and may cause a variety of adverse health effects. The hepatotoxicity of PFOS has attracted particular attention, given the fact that the liver has one of the highest PFOS accumulations among human tissues. In this study, we revealed that subchronic PFOS exposure may exacerbate carbon tetrachloride (CCl 4 )-induced liver fibrosis in animal models. Administration with 1 mg/kg PFOS every other day for 56 days dramatically enhanced CCl 4 -mediated liver injury and hepatic stellate cell (HSC) activation. Furthermore, PFOS exposure may promote the activation of high-mobility group box 1 (HMGB1)/toll-like receptor 4 (TLR4) signaling pathway through inducing the secre-

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Section: Discussionmentioning

confidence: 94%

“…Furthermore, reports also suggested that PFOS exposure may cause liver inflammation, which is indicative for liver damage. For instance, PFOS exposure disturbed the immune regulation of the liver of zebrafish via NF‐κB signaling 36 . Likewise, significant inflammatory cell infiltration was observed in rat liver after PFOS exposure 15 .…”

Section: Discussionmentioning

confidence: 99%

Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Wan

Ling

et al. 2022

Environmental Toxicology

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“…In a study on male zebrafish, it was shown that the activities of immune-related enzymes such as acid phosphatase (ACP), alkaline phosphatase (AKP), and myeloperoxidase (MPO) were inhibited and the activity of lysozyme (LSZ) was increased after PFOS exposure. The mRNA levels of immune-related factors IL-1β, IL-6, IL-15, TNF-α, TGF-β, IRF-1, IRF-3, IRF-7, RAG-1, and RAG-2 were significantly increased in a concentration- and time-dependent manner with increasing PFOS exposure, suggesting that PFOS can interfere with normal immune function in zebrafish [ 102 , 103 , 104 ].…”

Section: Effects Of Pfos On the Liver And Related Mechanisms Of Toxicitymentioning

confidence: 99%

“…Thus, the NF-κB signaling pathway can be activated after PFOS exposure [ 104 ]. Another study found that PFOS exposure increased ROS levels; increased the mRNA expression of IL-1β, IL-6, and TNF-α; and enhanced NF-κB activity in the liver [ 102 ]. In addition, PFOS can increase both TNF-α and IL-6 expression by activating the NF-κB signaling pathway, thus affecting the regulation of the immune system [ 103 ].…”

Section: Signaling Pathways Associated With Hepatotoxic Damage Caused...mentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.

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“…PFAS. PFOS, the most studied PFAS, activates NF-κB and significantly induces the production of TNF-α and IL-6 in Kupffer cells [ 297 ], in HAPI cells [ 298 ] and in microglial cells [ 299 ], as well as in the liver of zebrafish, indicating that PFOS facilitate pro-inflammatory cytokines secretion via NF-κB [ 300 ].…”

Section: Factors Modulating Covid-19: a Mechanistic Understanding Via...mentioning

confidence: 99%

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Clerbaux

Albertini

Amigó

et al. 2022

JCM

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Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution and exposure to chemicals) influence COVID-19 by applying the Adverse Outcome Pathway (AOP), which is well-established in regulatory toxicology. This framework aims to model the sequence of events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.

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The PFOS disturbed immunomodulatory functions via nuclear Factor-κB signaling in liver of zebrafish (Danio rerio)

Cited by 45 publications

References 75 publications

Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

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