The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

Hsueh, Tun-Pin; Lin, Weigan; Dalley, Jeffrey W.; Tsai, Tung Hu

doi:10.3390/biomedicines9101412

Cited by 23 publications

(13 citation statements)

References 109 publications

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“…Among the various compounds present in these plants, terpenoids represent the main effective component. Modern pharmacological studies have shown that Artemisia medicinal plants exert diuretic, expectorant, antiinflammatory, hemostatic, hypotensive, and antiallergic effects ( Chen et al., 2021 ; Hsueh et al., 2021 ; Hong et al., 2022 ). Owing to their similar morphological characteristics and chemical composition, Artemisia species are often mixed or substituted in different regions of China.…”

Section: Introductionmentioning

confidence: 99%

Comparative and phylogenetic analysis of complete chloroplast genomes from five Artemisia species

et al. 2022

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Artemisia Linn. is a large genus within the family Asteraceae that includes several important medicinal plants. Because of their similar morphology and chemical composition, traditional identification methods often fail to distinguish them. Therefore, developing an effective identification method for Artemisia species is an urgent requirement. In this study, we analyzed 15 chloroplast (cp) genomes, including 12 newly sequenced genomes, from 5 Artemisia species. The cp genomes from the five Artemisia species had a typical quadripartite structure and were highly conserved across species. They had varying lengths of 151,132–151,178 bp, and their gene content and codon preferences were similar. Mutation hotspot analysis identified four highly variable regions, which can potentially be used as molecular markers to identify Artemisia species. Phylogenetic analysis showed that the five Artemisia species investigated in this study were sister branches to each other, and individuals of each species formed a monophyletic clade. This study shows that the cp genome can provide distinguishing features to help identify closely related Artemisia species and has the potential to serve as a universal super barcode for plant identification.

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Section: Introductionmentioning

confidence: 99%

Comparative and phylogenetic analysis of complete chloroplast genomes from five Artemisia species

et al. 2022

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“…Screening of active compounds of Artemisia capillaries , Gardeniae Fructus , Baicalin, Isatidis Radix , and Ganoderma from literature and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP, https://tcmspw.com/index.phph), and met the standard of drug-likeness (DL) ≥ 0.18%. 17,43–47 However, the value of oral bioavailability was not considered due to injection. Targets were then predicted from two sources: (1) TCMSP database; (2) Targetnet (http://targetnet.scbdd.com/), with prediction accuracy ≥ 0.7, predicted probability > 0.9.…”

Section: Methodsmentioning

confidence: 99%

“…com/index.phph), and met the standard of drug-likeness (DL) ≥ 0.18%. 17,[43][44][45][46][47] However, the value of oral bioavailability was not considered due to injection. Targets were then predicted from two sources: (1) TCMSP database; (2) Targetnet (http://targetnet.scbdd.com/), with prediction accuracy ≥ 0.7, predicted probability > 0.9.…”

Section: Methodsmentioning

confidence: 99%

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Active Compounds Screening and Hepatoprotective Mechanism of Shuganning Injection Based on Network Pharmacology and Experimental Validation

Wang

Duan

shan

et al. 2022

Natural Product Communications

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Objective: The study aimed to analyze the core active compounds and the potential mechanism of Shuganning injection (SGNI) through network pharmacology with biological experiments. Methods: Active compounds and targets of SGNI were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Targetnet database, whereas the liver disease-related targets were identified through the Genecards and Online Mendelian Inheritance in Man databases. The “compound-target” and “protein-protein interaction” networks construction, core target identification, and pathway enrichment were then performed. Finally, the exploration of the mechanism of action for SGNI against acetaminophen (APAP)-induced liver injury in the HepaRG cells and validation of three identified protein targets was also carried out through western blot assay, including tumor protein p53 (p53, TP53), transcription factor Jun (Jun), and Caspase 3 (CASP3). Results: The result showed that a total of 312 active compounds of SGNI and 408 liver disease-related targets, as well as 131 core targets were revealed through databases, such as prostaglandin G/H synthase 1, prostaglandin G/H synthase 2, and nuclear factor NF-kappa B (NF-kB) p65 subunit (RELA). The core targets of SGNI were involved in regulating hepatitis B signaling pathway, NF-kB signaling pathway, Toll-like receptor signaling pathway, and tumor necrosis factor (TNF) signaling pathway. Moreover, results of molecular docking in this study indicated that chlorogenic acid, geniposide, baicalin, indirubin, and ganoderic acid A could act on RELA, JUN, TP53, TNF, CASP3, Caspase 8 (CASP8) and nuclear factor NF-kB p105 subunit (NFKB1). Similarly, results of western blot revealed that SGNI reduced the expression of p53, Jun, and Caspase 3 proteins in HepaRG cells as compared with the APAP group ( P < 0.01 or P < 0.05). Conclusion: The present study verified the therapeutic effects and mechanism of SGNI on liver diseases and pointed out new directions for further research.

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“…Artemisia capillaris (AC) is a traditional oriental medicinal herb with various pharmacological activities, including hepatoprotective, cholestasis, analgesic, and antipyretic [ 13 , 14 , 15 ]. AC contains a variety of flavonoids, phenolic acids, terpenoids, coumarins, chlorogenic acid, ascorbic acid, scoparone, and essential oil, which promotes anti-oxidant, anti-inflammatory, anti-steatotic, anti-viral, and anti-tumor effects [ 16 ]. In particular, a recent study demonstrated that AC treatment ameliorated the severity of trinitrozobenzoic acid (TNBS)-induced colitis by inhibiting reactive oxygen species (ROS) generation and downregulating pro-inflammatory signaling pathways such as STAT3/MAPK/NF-κB [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bamboo Shoot and Artemisia capillaris Extract Mixture Ameliorates Dextran Sodium Sulfate-Induced Colitis

Kim

Lee

et al. 2022

CIMB

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract and is characterized by recurrent chronic inflammation and mucosal damage of the gastrointestinal tract. Recent studies have demonstrated that bamboo shoot (BS) and Artemisia capillaris (AC) extracts enhance anti-inflammatory effects in various disease models. However, it is uncertain whether there is a synergistic protective effect of BS and AC in dextran sodium sulfate (DSS)-induced colitis. In the current study, we tested the combined effects of BS and AC extracts (BA) on colitis using in vivo and in vitro models. Compared with control mice, oral administration of DSS exacerbated colon length and increased the disease activity index (DAI) and histological damage. In DSS-induced colitis, treatment with BA significantly alleviated DSS-induced symptoms such as colon shortening, DAI, histological damage, and colonic pro-inflammatory marker expression compared to single extracts (BS or AC) treatment. Furthermore, we found BA treatment attenuated the ROS generation, F-actin formation, and RhoA activity compared with the single extract (BS or AC) treatment in DSS-treated cell lines. Collectively, these findings suggest that BA treatment has a positive synergistic protective effect on colonic inflammation compared with single extracts, it may be a highly effective complementary natural extract mixture for the prevention or treatment of IBD.

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The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

Cited by 23 publications

References 109 publications

Comparative and phylogenetic analysis of complete chloroplast genomes from five Artemisia species

Comparative and phylogenetic analysis of complete chloroplast genomes from five Artemisia species

Active Compounds Screening and Hepatoprotective Mechanism of Shuganning Injection Based on Network Pharmacology and Experimental Validation

Bamboo Shoot and Artemisia capillaris Extract Mixture Ameliorates Dextran Sodium Sulfate-Induced Colitis

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