2016
DOI: 10.1016/j.jsbmb.2015.08.010
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The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3

Abstract: The nuclear vitamin D receptor (VDR) is generally recognized as a ligand-dependent transcription factor that mediates the actions of its natural ligand, 1a,25-dihydroxyvitamin D 3 (1a,25(OH) 2 D 3 ) on multiple target genes involved in mineral homeostasis, bone development, as well as immune reactivity. As the VDR is widely distributed in nearly all cells of the body, it implies that the vitamin D endocrine system may regulate many cell types and functions. Experiments in VDR null mice established that the VDR… Show more

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Cited by 6 publications
(5 citation statements)
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“…The antigen‐presenting activity of DCs related to Th cell polarization was analysed using flow cytometry 34 . First, DCs were incubated in complete RPMI 1640 medium supplemented with 1 μg/mL LPS in the absence (LPS group) or presence (LPS + Cal group) of 10 nmol/L calcitriol, while DCs cultured in only complete RPMI 1640 medium were designated the control (control group).…”
Section: Methodsmentioning
confidence: 99%
“…The antigen‐presenting activity of DCs related to Th cell polarization was analysed using flow cytometry 34 . First, DCs were incubated in complete RPMI 1640 medium supplemented with 1 μg/mL LPS in the absence (LPS group) or presence (LPS + Cal group) of 10 nmol/L calcitriol, while DCs cultured in only complete RPMI 1640 medium were designated the control (control group).…”
Section: Methodsmentioning
confidence: 99%
“…The nuclear VDR is the ligand‐dependent transcription factor that mediates the action of its natural ligand 1,25(OH) 2 D (Vanherwegen et al . ). The optimal serum concentration of 25(OH)D has not been precisely defined in companion animals.…”
Section: Vitamin D – An Overviewmentioning
confidence: 97%
“…2015 ). The nuclear VDR is the ligand-dependent transcription factor that mediates the action of its natural ligand 1,25(OH) 2 D (Vanherwegen et al . 2015 ).…”
Section: Vitamin D Metabolismmentioning
confidence: 99%
“…5 On the other hand, vitamin D metabolites have also been reported to exert effects independent from VDR activation. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] For example, growth inhibition and induction of apoptosis by 1,25(OH)2D3 in breast cancer cells 7 persisted in VDR-knockout mice. 1,25(OH)2D3 has been shown to interact with MARRS (membrane-associated rapid response steroid binding protein) for precise regulation of phosphate uptake.…”
Section:  Introductionmentioning
confidence: 99%