The phenotypical and functional characteristics of cord blood monocytes and CD14−/low/CD16+ dendritic cells can be relevant to the development of cellular immune responses after transplantation

Morgado, José Mário; Pratas, Rui; Laranjeira, Pires; Henriques, Ana; Crespo, Inês; Regateiro, Fernando; Paiva, Artur

doi:10.1016/j.trim.2007.11.002

Cited by 15 publications

(14 citation statements)

References 52 publications

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“…The phenotypical and functional characteristics of blood monocytes and CD14 ¡/low /CD16 + DCs have also been shown to be relevant to the development of the cellular immune responses after transplantation (Morgado et al 2008). Despite the low frequencies of cells expressing cytokines in the absence of stimulation, monocytes and DCs did produce cytokines upon stimulation.…”

Section: Discussionmentioning

confidence: 99%

Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers

et al. 2011

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Elite level athletes seem to be prone to illness especially during heavy training phases. The aim of this study was to investigate the influence of long term intensive training on the functional features of innate immune cells from high competitive level swimmers, particularly the production of inflammatory mediators and the possible relationship with upper respiratory symptoms (URS) occurrence. A group of 18 swimmers and 11 healthy non athletes was studied. Peripheral blood samples were collected from athletes after 36 h of resting recovery from exercise at four times during the training season and at three times from non athletes. Samples were incubated in the presence or absence of LPS and IFN-γ and the frequency of cytokine-producing cells and the amount produced per cell were evaluated by flow cytometry. In addition, plasma cortisol levels were measured and URS recorded through daily logs. The athletes, but not the controls, showed a decrease in the number of monocytes, neutrophils, and dendritic cell (DC) subsets and in the amount of IL-1β, IL-6, IL-12, TNF-α, and MIP-1β produced after stimulation, over the training season. Differences were most noticeable between the first and second blood collections (initial increase in training volume). Athlete's cortisol plasma levels partially correlated with training intensity and could help explain the reduced in vitro cell response to stimulation. Our results support the idea that long-term intensive training may affect the function of innate immune cells, reducing their capacity to respond to acute challenges, possibly contributing to an elevated risk of infection.

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Section: Discussionmentioning

confidence: 99%

Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers

et al. 2011

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“…To date, HUCBCs have been used in more than 8000 transplants for children and adults. Patients who receive HUCBC transplants from a relative are at a significantly lower risk of GVHD and are less prone to rejection than either bone marrow or peripheral blood stem cells (Morgado et al, 2008; Takahashi et al, 2007b). HUCB-derived mononuclear cells have potential to proliferate, differentiate, and to secrete factors possibly beneficial for the host brain tissue in vivo (Neuhoff et al, 2007).…”

Section: Cellular Therapies From Different Cell Sourcesmentioning

confidence: 99%

Cell based therapies for ischemic stroke: From basic science to bedside

Liu

Yan

et al. 2014

Progress in Neurobiology

166

143

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Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications.

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“…Numerous studies having shown that HUCBC treatment of rodents does not elicit GVHD (Graft Versus Host Disease), a leading cause of death in patients that have received stem cell transplants (Li et al, 2001b; Lu et al, 2002; Henning et al, 2004; Hu et al, 2006). Patients who receive HUCBC transplants from a relative are significantly at a lower risk of GVHD, and are less likely to reject the transplant compared to either bone marrow or peripheral blood stem cells (Takahashi et al, 2007; Morgado et al, 2008). Factors that may be beneficial to the host brain in vivo are secreted by HUCB-derived mononuclear cells as they proliferate and differentiate (Neuhoff et al, 2007).…”

Section: Neurorestorative Treatment Of Stroke With Cell-based Therapymentioning

confidence: 99%

Neurorestorative Therapy for Stroke

Chen

Venkat

Zacharek

et al. 2014

Front. Hum. Neurosci.

146

129

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Ischemic stroke is responsible for many deaths and long-term disability world wide. Development of effective therapy has been the target of intense research. Accumulating preclinical literature has shown that substantial functional improvement after stroke can be achieved using subacutely administered cell-based and pharmacological therapies. This review will discuss some of the latest findings on bone marrow-derived mesenchymal stem cells (BMSCs), human umbilical cord blood cells, and off-label use of some pharmacological agents, to promote recovery processes in the sub-acute and chronic phases following stroke. This review paper also focuses on molecular mechanisms underlying the cell-based and pharmacological restorative processes, which enhance angiogenesis, arteriogenesis, neurogenesis, and white matter remodeling following cerebral ischemia as well as an analysis of the interaction/coupling among these restorative events. In addition, the role of microRNAs mediating the intercellular communication between exogenously administered cells and parenchymal cells, and their effects on the regulation of angiogenesis and neuronal progenitor cell proliferation and differentiation, and brain plasticity after stroke are described.

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The phenotypical and functional characteristics of cord blood monocytes and CD14−/low/CD16+ dendritic cells can be relevant to the development of cellular immune responses after transplantation

Cited by 15 publications

References 52 publications

Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers

Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers

Cell based therapies for ischemic stroke: From basic science to bedside

Neurorestorative Therapy for Stroke

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