The phosphate ester group in secondary metabolites

Abstract

The structural, biological, and pharmacological profiles of phosphorylated secondary metabolites is presented. An overview of the phosphorylation methodologies employed in their total syntheses is also included.

Recent Research Progress: Discovery of Anti-Plant Virus Agents Based on Natural Scaffold

“…In addition, natural products readily interact with biological targets, thereby exhibiting specific biological activities ( Lowe, 2014 ; Bauer and Brӧnstrup, 2014 ). Identifying natural product structure and studying biological activity are of great significance for drug discovery ( Chen and Song, 2021 ; Della-Felice et al, 2022 ). The discovery of anti-plant virus agents based on natural products is an important research direction in the prevention and control of plant virus diseases and has always attracted much attention ( Eckert et al, 2003 ; Carli et al, 2012; Katayama et al, 2013 ; Wang et al, 2015 ).…”

Improving Site Selectivity in Phosphorylation of Amphiphilic Diols through Catalyst Design

“…[2] Furthermore, phosphates of various small molecules bear important biological functions. [3] For instance, inositol phosphates are involved in numerous cell regulation mechanisms, [4] while phospholipids and phosphorylated polysaccharides are major components of cell membranes. [5] Additionally, phosphorylated prodrugs have been occasionally introduced in order to improve the water solubility of the parent alcohol-carrying therapeutic compounds and, accordingly, their bioavailability.…”

“…Phosphorylation of hydroxyl‐decorated side chains in proteins constitutes a fundamental step of numerous signal transduction pathways in biological systems [2] . Furthermore, phosphates of various small molecules bear important biological functions [3] . For instance, inositol phosphates are involved in numerous cell regulation mechanisms, [4] while phospholipids and phosphorylated polysaccharides are major components of cell membranes [5] .…”

A new approach to phosphorylation of nucleosides using oxyonium phosphobetaines as intermediates

“…Similarly as for P(III) compounds, reactive P-[LG] derivatives can be used, e.g., P(O)Cl 3 (Jakubovska et al, 2018) or pyrophosphates (Dixit et al, 1981). Alternatively, inert phosphate esters can be activated using various condensing agents and applied in situ for phosphorylation (Della-Felice et al, 2022). Della-Felice et al (2022) have recently reviewed several phosphorylation methodologies.…”

“…Alternatively, inert phosphate esters can be activated using various condensing agents and applied in situ for phosphorylation (Della-Felice et al, 2022). Della-Felice et al (2022) have recently reviewed several phosphorylation methodologies. Despite the large number of known approaches, new phosphorylation strategies are being developed, showing a steady demand for phosphorylated compounds.…”