The Photodynamic Bone Stabilization System in the Treatment of Humerus Fractures: A Prospective Clinical Trial

Vegt, P.A.; Verbruggen, J.P.A.M.; Gausepohl, T.; Vroemen, J.P.A.M.; Schäfer, Walter; Pennig, D.; Muir, Jeffrey M.

doi:10.7759/cureus.2809

Cited by 5 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a prospective study on 33 patients with traumatic humeral fractures treated with the polymeric rod showed a complete healing in the whole sample of patients, with good pain control and satisfying functional outcomes. The procedure's complication rate was around 35% which is not higher than what was reported in literature for other stabilization systems [ 26 ]. A comparison study among cemental plate fixation, intramedullary nailing, and photodynamic stabilization in the treatment of 105 malignant pathologic humeral fractures was conducted.…”

Section: Discussionmentioning

confidence: 72%

“…The ability of the system to get into contact with the cortical bone, filling the medullary space, significantly reduces the rotatory instability of the traditional intramedullary devices that require the use of further hardware, such as screws, to provide stability [ 24 , 25 ]. Also, if necessary, the hardened polymer can be used as a substrate for supplemental osteosynthesis as screws can be inserted as in conventional nails, to provide supplemental stability [ 26 ]. A preliminary study reported no complications in the treatment of 36 osteoporotic and metastatic fractures of non-weight-bearing bones apart from one surgical revision of a humeral fracture [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemotherapy and Simultaneous Photodynamic Bone Stabilization of Upper Limbs in Metastatic Renal Cancer Disease: Case Report and Literature Review

Albertini

Conti

Ratto

et al. 2020

Case Reports in Medicine

View full text Add to dashboard Cite

Introduction. Metastatic bone disease represents a systemic pathology that heavily affects the quality of life of oncologic patients causing pain and functional disability. Methodology. We present the case of a patient with a history of renal cell cancer presenting pathologic fractures of both humeri and proximal right radius. Results. After a careful multidisciplinary approach, an adjuvant anticancer therapy and a photodynamic bone stabilization procedure were performed with a minimally invasive technique aiming to minimize pain and local disease progression, while restoring functional autonomy and improving the patient’s quality of life. Electrochemotherapy was delivered on the lytic bone lesions with extraskeletal involvement of the proximal left humerus and the proximal right radius, and then polymeric bone stabilization was performed on both humeri. At two months of follow-up, the patient presented satisfactory functional scores (MSTS score: 12/30 bilaterally; DASH scores: 46.7/100 for the right side and 48.3/100 for the left one), and pain was well controlled with opioid analgesics. Radiographs showed good results in terms of ossification of lytic bone lesions and durability of polymeric stabilization. At four months of follow-up, the patient reported a stable clinical scenario. Six months after surgery, due to extremely poor prognosis after the progression of primary disease, the patient was referred to palliative care and died shortly thereafter. Conclusion. Over the last decade, the management of metastatic bone disease has changed. Low-toxicity and minimally invasive procedures such as electrochemotherapy and polymeric bone stabilization might be performed concomitantly in selected patients, as an alternative to radiation therapy and to more demanding surgical procedures such as plating and adjuvant cementing.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Electrochemotherapy and Simultaneous Photodynamic Bone Stabilization of Upper Limbs in Metastatic Renal Cancer Disease: Case Report and Literature Review

Albertini

Conti

Ratto

et al. 2020

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…The PBSS system has been successfully used in the treatment of pathological osteolysis and fractures of the humerus, metacarpal and forearm fractures, as well as for stabilization of pubic bone and acetabular fractures [6,[12][13][14][15]. In a randomized controlled study done by Zyskowski, et al the outcome after osteosynthesis comparing AO technique and PBSS in distal fibula fractures showed that the use of the IlluminOss ® System leads to a reduction in postoperative complications and early hospital discharge in the elderly [16].…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…In a randomized controlled study done by Zyskowski, et al the outcome after osteosynthesis comparing AO technique and PBSS in distal fibula fractures showed that the use of the IlluminOss ® System leads to a reduction in postoperative complications and early hospital discharge in the elderly [16]. Moreover, it´s use is of particular value for the surgical repair of osteoporotic fractures, offering improved stability and excellent clinical outcomes [14].…”

Section: Surgical Proceduresmentioning

confidence: 99%

A Novel Technique for Treatment of Peri-Implant Tibial Shaft Fracture with Pre-Existing Bimalleolar Ankle Fracture with a Combination of IlluminOss® Photodynamic Bone Stabilization System and Osteosynthesis

Said¹,

Saad²,

Johannes³

2023

Int J Foot Ankle

View full text Add to dashboard Cite

“…A photodynamic bone stabilization system (PBSS) was developed in 2010 for the treatment of fractures, especially pathologic, osteoporotic, and impending fractures [ 1 , 2 ]. The system is based on a light curable monomer within a balloon catheter that can provide longitudinal and rotational stability by conforming to the shape of the intramedullary canal upon exposure to blue light to form a rigid implant in the target bone [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic bone stabilization for traumatic and pathologic fractures: a systematic review of utilization, complications, and patient-reported outcomes

Zhu,

McNassor,

Hecht II

et al. 2024

Eur J Orthop Surg Traumatol

View full text Add to dashboard Cite

Introduction The photodynamic bone stabilization system (PBSS) was was developed in 2010, and in 2018 gained FDA approval in the United States. Given its relative novelty, our analysis sought to analyze the available literature exploring the indications, outcomes, and complications of the PBSS. Methods We performed a systematic review (PROSPERO registration of study protocol: CRD42022363065, October 8th, 2022). PubMed, EBSCOHost, and Google Scholar electronic databases were queried to identify articles evaluating PBSS in the treatment of pathologic or traumatic fractures between January 1 2010 and 15 October 2022. The quality of the included studies was assessed using the Methodological Index for Nonrandomized Studies tool. Results Our initial search yielded 326 publications, which were then screened for appropriate studies that aligned with the purpose of our review. A total of thirteen studies, comprising seven case series, four case reports, and two cohort studies. The total sample size of the included studies consisted of 345 patients, with 242 females (70%) and 103 males (30%). The implants were most commonly utilized in the humerus (41%), radius (12%), and metacarpal (12%). The most common complications were related to broken implants (5%) and dislocation (1%). Most studies reported complete fracture healing and return of full strength and range of motion. Conclusion Despite being a relatively novel technology, PBSS appears to be a viable option for fracture stabilization. Most studies included in our analysis reported complete fracture healing and return of function with minimal complications.

show abstract

The Photodynamic Bone Stabilization System in the Treatment of Humerus Fractures: A Prospective Clinical Trial

Cited by 5 publications

References 28 publications

Electrochemotherapy and Simultaneous Photodynamic Bone Stabilization of Upper Limbs in Metastatic Renal Cancer Disease: Case Report and Literature Review

Electrochemotherapy and Simultaneous Photodynamic Bone Stabilization of Upper Limbs in Metastatic Renal Cancer Disease: Case Report and Literature Review

A Novel Technique for Treatment of Peri-Implant Tibial Shaft Fracture with Pre-Existing Bimalleolar Ankle Fracture with a Combination of IlluminOss® Photodynamic Bone Stabilization System and Osteosynthesis

Photodynamic bone stabilization for traumatic and pathologic fractures: a systematic review of utilization, complications, and patient-reported outcomes

Contact Info

Product

Resources

About